Evolutionary Models and Studies in Human Diversity 1978
DOI: 10.1515/9783110800043.325
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Physical Anthropology of the Angami Nagas (Nagaland, India)

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“…8 A higher lipid solubility and a larger percentage of drug in the unionized state facilitate transfer across the blood-brain barrier. 9 A poor association between plasma hydromorphone concentrations and analgesic effect has also been documented. 10 There appears to be a delay of 10 to 20 minutes between peak plasma concentration and maximum analgesic effect, and it is postulated to be because of the low lipid solubility of hydromorphone, resulting in a lag time in penetrating the blood-brain barrier.…”
Section: Pk-pd Characteristics Of Morphine Hydromorphone and Fentanylmentioning
confidence: 99%
“…8 A higher lipid solubility and a larger percentage of drug in the unionized state facilitate transfer across the blood-brain barrier. 9 A poor association between plasma hydromorphone concentrations and analgesic effect has also been documented. 10 There appears to be a delay of 10 to 20 minutes between peak plasma concentration and maximum analgesic effect, and it is postulated to be because of the low lipid solubility of hydromorphone, resulting in a lag time in penetrating the blood-brain barrier.…”
Section: Pk-pd Characteristics Of Morphine Hydromorphone and Fentanylmentioning
confidence: 99%
“…Aggami Nagas, India (MF) Set and Set (1978) Arora, North India (MF) Kalla (1969) Williams-Blangero and Blangero (1991) Tibet (MF) Kalla and Tiwari (1970) …”
Section: South Asiamentioning
confidence: 99%