Purpose: To evaluate the color stability of 3D-printed interim restorations with different surface treatments while immersed in various staining solutions or beverages (artificial saliva, tea, coffee, and wine) for 6 months. Material and Methods: An acrylic tooth was prepared for an all-ceramic fullcoverage restoration. A laboratory scanner was used to digitize the prepared abutment tooth. A virtual all-ceramic full-coverage restoration was designed on the digitized abutment tooth using a laboratory CAD/CAM software. Eighty abutment teeth and interim restorations were 3D-printed with tooth-colored photopolymerizing resin. The restorations were randomly allocated into two different groups: Polish and Optiglaze. For the Polish group, interim restorations were finished and polished with aluminum oxide finishers/polishers. For the Optiglaze group, one layer of nanofilled, lightpolymerizing protective coating was then applied. The 80 printed interim crowns were divided into 4 different groups depending on where they would be immersed: Artificial saliva, coffee, wine, and tea. After the sample allocations, there were 8 experimental groups. Each group was allocated with 10 specimens. Color measurements were obtained using a digital spectrophotometer in conjunction with The CIE L*a*b* system before the immersion and 6 months after the immersion. Two-way analysis of variance (ANOVA) was used to test the effects of surface treatment, immersion liquid, and their interaction on E at 6-month post-immersion. Fisher's protected least significant differences (LSD) was used as post hoc test to compare groups differences (α = .05). Results: There were significant effects of surface treatment [F(1,72) = 13.39, p = 0.000], immersion liquid [F(3,72) = 74.18, p = 0.000], and their interaction [F(3,72) = 16.33, p = 0.000] on E at 6-month post-immersion at the α = .05 level. The polish group showed significantly higher E than the Optiglaze group when immersed in coffee (p < 0.001) and wine (p = 0.015). The Optiglaze group showed significantly higher E than the polish group that was immersed in artificial saliva (p < 0.001). The wine group showed higher E than all other immersion liquid groups for both polish and Optiglaze surface treatments (p < 0.001 for all comparisons). L* showed a reduction that was significantly higher than the 2.0 acceptability threshold in the wine-polish (p < 0.001) and wine-Optiglaze (p < 0.001) groups.E showed a color change that was significantly higher than the perceptibility and acceptability thresholds for all the groups under polish surface treatment (p < 0.001).E also showed a color change that was significantly higher than the perceptibility and acceptability thresholds for artificial saliva, tea, and wine under Optiglaze surface treatment (p = 0.004). Conclusions: 3D-printed interim restorations showed significant discoloration after 6-months immersions in the artificial saliva and common beverages (including tea, coffee, and wine). Among all the chromogenic beverages, red wine caused the most signific...