Physical and Mental Impact of Psoriasis Severity as Measured by the Compact Short Form-12 Health Survey (SF-12) Quality of Life Tool

Abstract

The Short Form-12 Health Survey (SF-12) is used to assess the patient’s quality of life (QoL) using the physical component score (PCS) and the mental component score (MCS). The purpose of this study was to determine whether the SF-12 PCS and MCS are associated with psoriasis severity and to compare QoL between Murdough Family Center for Psoriasis (MFCP) patients and patients with other major chronic diseases included in the National Survey of Functional Health Status data. We used data from 429 adult patients enrolled in MFCP. Psoriasis Area Severity Index (PASI) was used to assess psoriasis severity at the time of completion of the SF-12 questionnaire. Other variables included age, sex, body mass index, psoriatic arthritis, psychiatric disorders, and comorbidities. Linear regression models were used to estimate effect sizes ±95% confidence intervals. For every 10-point increase in PASI, there was a 1.1±1.3 unit decrease in MCS (P = 0.100) and a 2.4±1.3 unit decrease in PCS (P<0.001). Psoriasis severity was associated with PCS and MCS after adjusting for variables, although the strength of the relationship was attenuated in some models. Psoriasis severity is associated with decreased QoL. SF-12 may be a useful tool for assessing QoL among psoriasis patients.

Evaluation of Some Psychological Factors in Psoriatic Patients

“…While Anti-Tumor Necrosis Factor (Anti-TNF) therapy is associated with improvement in both physical and mental status in psoriasis patients, the role of this treatment on mental health is not known yet (13,14). Many studies have shown that psoriasis negatively impacts the quality of life and its co-morbid conditions (15)(16)(17)(18)(19)(20). However, our findings have not confirmed these results.…”

Value in innovative dermatological treatments

“…Several objective health related quality of life studies have compared inflammatory skin diseases with other major diseases such as diabetes, cancers, arthritis and cardio vascular diseases (4,5). It is evident from these studies that patients with psoriasis suffer to a similar extent.…”

Quantifying harmful effects of psoriatic diseases on quality of life: Cardio-metabolic outcomes in psoriatic arthritis study (COMPASS)

“…Studies conducted previously from across the globe reveal that both psoriasis and psoriatic arthritis are associated with considerable morbidity and reduced quality of life [12][13][14][15][16]. These diseases are associated with significant pain and physical disability [17], and psoriasis, in particular, has also been linked to significant psychological distress, depression (in greater than 30% of patients), and even increased risk of suicidal ideations [hazard ratio of 1.44 (1.32-1.57) compared to controls] [18][19][20].…”