“…Although isotretinoin has a strong effect, which makes it the first choice in the treatment of severe and refractory acne, it is a vitamin A analog and has some side effects and complications such as teratogenicity, liver dysfunction, and negative psychological effects. 4 It was reported in previous studies that acne might cause mood disorders, including depression, and reduce the quality of life, like many chronic diseases. Acne vulgaris was associated with social and psychological disorders such as low self-esteem, depression, social phobia, anxiety, and suicidal thoughts.…”