Physical activity reduces risk for colon polyps in a multiethnic colorectal cancer screening population

Sánchez, Nelson F.; Stierman, Bryan; Saab, Said; Mahajan, Divya; Yeung, Howa; François, Fritz

doi:10.1186/1756-0500-5-312

Cited by 51 publications

(44 citation statements)

References 30 publications

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“…In one of the earliest reports to examine polyp prevalence by race, Lieberman and colleagues (10) found that blacks had a higher risk of larger polyps (> 9mm) compared to whites, especially African-American women. Lebwohl and colleagues (5) found an increased risk among blacks compared to whites of proximal and advanced neoplasm but also reported an association with any adenoma (OR 1.76 (95% CI 1.52–2.04)) findings which were recently corroborated by Sanchez et al (RR 3.0 (95% CI 1.1–8.3))(7). Others(8, 9), however, have observed a similar risk of prevalent and advanced adenomas by race, but a higher risk of proximal adenomas in blacks compared to whites – proximal location is associated with poorer survival among patients with invasive cancer (31–33).…”

Section: Discussionmentioning

confidence: 70%

The Association of Age and Race and the Risk of Large Bowel Polyps

Wallace

Burke

Ahnen

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Blacks have a higher incidence of colorectal cancer (CRC) and a younger age at diagnosis compared to Whites. Few studies have investigated racial differences in risk of metachronous adenomas and serrated polyps whether this risk differs by polyp characteristics or age of patient. Methods We analyzed data pooled from three placebo-controlled adenoma chemoprevention trials to explore racial differences in the risk of large bowel polyps in patients ≤50 and > 50 years of age. Using generalized linear regression, we estimated risk ratios (RR) and 95% confidence intervals (CI) as measures of the association between race and risk of one or more adenomas or serrated polyps after randomization. Results Among the 2605 subjects who completed at least one follow-up exam, blacks ≤50 years of age had a higher risk of any conventional adenoma (RR 1.70, 95% CI 0.99–2.92) and advanced neoplasms (RR 4.05, 95% CI 1.43–11.46) and a non-significantly lower risk of serrated polyps (RR 0.75 (95% CI 0.34–1.62) compared to whites. Among patients > 50 years there was no racial difference in risk of adenomas (RR 1.08, 95% CI 0.92–1.27) or advanced neoplasms (RR 1.05, 95% CI 0.71–1.56)). However, blacks had a significantly lower risk of serrated polyps (RR 0.65, 95% CI 0.49–0.87) than whites. Conclusions Our results demonstrate a higher risk of metachronous adenomas in blacks compared to whites at younger ages. Impact Our results suggest that the racial disparity in CRC incidence may be due to an excess of neoplasia in younger blacks.

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Section: Discussionmentioning

confidence: 70%

The Association of Age and Race and the Risk of Large Bowel Polyps

Wallace

Burke

Ahnen

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Colon polyp is a common digestive system disease, with a high clinical detection rate (9,10). Colorectal polyps are pathologically classified as neoplastic or nonneoplastic polyps (11).…”

Section: Discussionmentioning

confidence: 99%

Should antibiotics be administered after endoscopic mucosalresection in patients with colon polyps?

Shi¹,

Qiu²,

Liu³

et al. 2016

Turk J Med Sci

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IntroductionGastrointestinal polyps are protruded masses formed by focal hyperplasia of the gastrointestinal mucosa. Based on the site of occurrence, gastrointestinal polyps are classified as esophageal polyps, gastric polyps, duodenal polyps, small bowel polyps, and colon and rectum polyps. Thus, any protruding lesions in the colon can be termed as colon polyps.Colon polyps can cause abdominal discomfort, abdominal distension, abdominal pain, constipation, and diarrhea, among other symptoms. In some cases, colon polyps may lead to bleeding, resulting in melena or bloody stool (1,2). If this condition is not promptly treated, it could lead to cancer development. The early identification and removal of these lesions is highly effective for reducing morbidity and mortality related to colorectal carcinoma (3).The detection rate of colon polyps has significantly improved after the recent advancements in endoscopic techniques. Endoscopic treatment of this condition is currently preferred to traditional surgical treatment, as it is associated with fewer side effects and complications (4). Colonoscopic polypectomy reduces the incidence of colorectal cancer and mortality (5).At present, endoscopic mucosal resection (EMR) is widely used to treat polypoid lesions of the digestive tract, considering the minimally invasive nature, minimal trauma, fewer complications, and reliable clinical efficacy (6-8). However, it is currently unclear whether antibiotic administration is necessary after EMR of colon polyps to prevent the development of infection.In the present study, we aimed to evaluate whether the postoperative use of antibiotics has any effect on the prognosis of patients undergoing EMR for colon polyps. Materials and methods General informationThis prospective study was approved by the institutional ethics committee of Xintai Municipal People's Hospital. Informed consent was obtained from all the participants before the start of the study.Background/aim: Endoscopic mucosal resection (EMR) is widely used for treating gastrointestinal polypoid lesions. However, it is currently unclear whether antibiotic administration is necessary after EMR of colon polyps to prevent infection. We aimed to assess whether antibiotic administration is essential in such conditions. Materials and methods:In total, 115 patients with colon polyps were randomly assigned to 3 groups based on the treatment given after EMR: Group A, no antibiotics treatment after EMR (n = 38); Group B, administration of levofloxacin after EMR (n = 38); and Group C, administration of ceftazidime after EMR (n = 39). Results:The colon polyps were completely removed by EMR in all cases without any serious complications. Although infection developed in 2 cases in Group A, it was resolved via levofloxacin injection over 3 days; infection did not develop in any cases in Group B and C. The postoperative infection rate was not significantly different among Groups A, B, and C. After 6 months, we noted that the wound surface had properly healed and there was no relapse of co...

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“…Patients who reported exercising one or more hours weekly were regarded as "physically active" [16].…”

Section: Study Populationmentioning

confidence: 99%

Incidence and risk factors for colorectal neoplasia in patients with oral squamous cell carcinoma

et al. 2014

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Aim:Colorectal adenoma and cancer are not regarded as being associated with primary oral cancer. The aim of this study was to determine whether screening colonoscopy should be performed for patients with oral cancer in addition to the upper gastrointestinal endoscopic screening that is now routinely performed. Method:Between 2007 and 2013, 162 patients with oral squamous cell carcinoma were enrolled at Tokyo Dental College, Ichikawa General Hospital, and 136 individuals were assigned to colonoscopic surveillance. Advanced neoplasia was defined as adenomas 10 mm, adenomas with villous histology or high-grade dysplasia regardless of size, and invasive cancers. Associations between advanced neoplasia and clinical factors, including age, sex, body mass index, physical activity, smoking, alcohol consumption, and oral cancer site and staging, were determined.Results: Advanced neoplasia, including five invasive cancers, was identified in 32 (23.5%) subjects. An age-and sex-adjusted multivariate analysis revealed that smoking (Brinkmann index >400; OR= 3.24, 95 % CI=1.28-8.18), alcohol consumption (lifetime pure ethanol consumption >600 L; OR= 2.84, 95 % CI=1.18-6.79), and a diagnosis of cancer of the floor of the mouth (OR=7.97, 95% CI=2.49-25.46) were independent risk factors for advanced colorectal neoplasia. Conclusion:The prevalence of advanced colorectal neoplasia is unexpectedly high in patients with oral cancer. It should be recognised as a second primary tumour of oral cancer. Screening of oral cancer patients by colonoscopy should be routine practice, particularly among smokers and patients with a high intake of alcohol and cancer of the floor of the mouth. What does this study add to the literature?This is the first study suggesting a significantly high prevalence of colorectal neoplasia occurs in patients with oral cancer. Although colonoscopy is not usually recommended for routine evaluation of patients with oral cancer, we recommend that screening large bowel neoplasia should be offered.

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Physical activity reduces risk for colon polyps in a multiethnic colorectal cancer screening population

Cited by 51 publications

References 30 publications

The Association of Age and Race and the Risk of Large Bowel Polyps

The Association of Age and Race and the Risk of Large Bowel Polyps

Should antibiotics be administered after endoscopic mucosalresection in patients with colon polyps?

Incidence and risk factors for colorectal neoplasia in patients with oral squamous cell carcinoma

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