Physical activity, polygenic risk score, and colorectal cancer risk

Chen, Xuechen; Guo, Feng; Chang‐Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann

doi:10.1002/cam4.5072

Cited by 6 publications

(2 citation statements)

References 35 publications

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“…Other previous studies have examined the association between PRS and CRC along with various risk factors, including lifestyle [ 29 , 30 ], physical activity [ 31 ], consumption of red and processed meat [ 32 ], alcohol intake [ 33 ], smoking [ 34 ], frequency of colonoscopy [ 35 , 36 ], and the use of non-steroidal anti-inflammatory drugs [ 37 ]. However, these previous studies primarily focused on PRS in isolation or in combination with just one additional relevant factor in their analyses.…”

Section: Discussionmentioning

confidence: 99%

High polygenic risk score is a risk factor associated with colorectal cancer based on data from the UK Biobank

Yang,

Narasimhan,

Zhan

2023

PLoS ONE

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Colorectal cancer (CRC) is a common cancer among both men and women and is one of the leading causes of cancer death worldwide. It is important to identify risk factors that may be used to help reduce morbidity and mortality of the disease. We used a case-control study design to explore the association between CRC, polygenic risk scores (PRS), and other factors. We extracted data about 2,585 CRC cases and 9,362 controls from the UK Biobank, calculated the PRS for these cases and controls based on 140 single nucleotide polymorphisms, and performed logistic regression analyses for the 11,947 cases and controls, for an older group (ages 50+), and for a younger group (younger than 50). Five significant risk factors were identified when all 11,947 cases and controls were considered. These factors were, in descending order of the values of the adjusted odds ratios (aOR), high PRS (aOR: 2.70, CI: 2.27–3.19), male sex (aOR: 1.52, CI: 1.39–1.66), unemployment (aOR: 1.47, CI: 1.17–1.85), family history of CRC (aOR: 1.44, CI: 1.28–1.62), and age (aOR: 1.01, CI: 1.01–1.02). These five risk factors also remained significant in the older group. For the younger group, only high PRS (aOR: 2.87, CI: 1.65–5.00) and family history of CRC (aOR: 1.73, CI: 1.12–2.67) were significant risk factors. These findings indicate that genetic risk for the disease is a significant risk factor for CRC even after adjusting for family history. Additional studies are needed to examine this association using larger samples and different population groups.

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Section: Discussionmentioning

confidence: 99%

High polygenic risk score is a risk factor associated with colorectal cancer based on data from the UK Biobank

Yang,

Narasimhan,

Zhan

2023

PLoS ONE

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“…Recently, a meta-analysis evidenced the protective influence of moderate to high PA in digestive tract cancers [141], given the existence of a direct correlation between healthy lifestyle index, including PA, and CRC prevalence [142]. An increased exercise level was related to a reduction in CRC relative risk of up to 20% [143], as adequate PA is able to counteract CRC polygenic risk [144] and ameliorate the overall survival rate after surgery resection [145]. The exact mechanisms relating to CRC and PA are still unclear; however, it could be speculated that IR, chronic inflammation, and dysbiosis improvement represent key events of exercise-mediated cancer prevention [146,147].…”

Section: Physical Activitymentioning

confidence: 99%

Metabolic Alteration Bridging the Prediabetic State and Colorectal Cancer

Colloca,

Donisi,

Anastasio

et al. 2024

Cells

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Prediabetes and colorectal cancer (CRC) represent compelling health burdens responsible for high mortality and morbidity rates, sharing several modifiable risk factors. It has been hypothesized that metabolic abnormalities linking prediabetes and CRC are hyperglycemia, hyperinsulinemia, and adipokines imbalance. The chronic stimulation related to these metabolic signatures can favor CRC onset and development, as well as negatively influence CRC prognosis. To date, the growing burden of prediabetes and CRC has generated a global interest in defining their epidemiological and molecular relationships. Therefore, a deeper knowledge of the metabolic impairment determinants is compelling to identify the pathological mechanisms promoting the onset of prediabetes and CRC. In this scenario, this review aims to provide a comprehensive overview on the metabolic alterations of prediabetes and CRC as well as an overview of recent preventive and therapeutic approaches for both diseases, focusing on the role of the metabolic state as a pivotal contributor to consider for the development of future preventive and therapeutic strategies.

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