Physical activity limits pulmonary endothelial activation in sickle cell SAD mice

Aufradet, Émeline; Douillard, Aymeric; Charrin, Emmanuelle; Romdhani, Aymen; Souza, Geneviève De; Bessaad, Amine; Faes, Camille; Bourgeaux, Vanessa; Chirico, Erica N.; Canet-Soulas, Emmanuelle; Pialoux, Vincent; Martin, Cyril

doi:10.1182/blood-2013-10-534982

Cited by 16 publications

(22 citation statements)

References 10 publications

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“…Alternatively, exercise training may be associated with attenuation of the acute phase response to exercise in SCA. This is plausible given that physical training is associated with reduced endothelial activation and oxidative stress in sickle cell mice exposed to hypoxia/reoxygenation conditions (Aufradet , et al 2014, Charrin , et al 2015). With the exception of the relationship observed with absolute monocyte count, cardiopulmonary fitness was not significantly associated with the acute phase response of any other biomarker measured in this study.…”

Section: Discussionmentioning

confidence: 97%

The acute phase inflammatory response to maximal exercise testing in children and young adults with sickle cell anaemia

et al. 2015

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Summary Although individuals with sickle cell anaemia (SCA) have elevated baseline inflammation and endothelial activation, the acute phase response to maximal exercise has not been evaluated among children with SCA. We measured the acute phase response to maximal exercise testing for soluble vascular cell adhesion molecule (sVCAM) as well as interleukin 6 (IL6), total white blood cell count (WBC), C-reactive protein (CRP) and D-dimer in 60 children with SCA and 30 controls at baseline, immediately after, and 30, 60 and 120 min following exercise. Despite higher baseline levels of all biomarkers except CRP, the acute phase response from baseline to immediately after exercise was significantly greater in subjects versus controls for CRP (2.1 vs. 0.2 mg/l, p = 0.02) and D-dimer (160 vs. 10 μg/l , p < 0.01) only. Similar between-group trends were observed over time for all biomarkers, including sVCAM, IL6, total WBC, CRP and D-dimer. Lower fitness, defined by peak oxygen consumption (VO2), was independently associated with greater acute phase responses to exercise for sVCAM. Our results suggest maximal exercise may not be associated with any greater escalation of endothelial activation or inflammation in SCA and provide preliminary biomarker evidence for the safety of brief, high-intensity physical exertion in children with SCA.

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Section: Discussionmentioning

confidence: 97%

The acute phase inflammatory response to maximal exercise testing in children and young adults with sickle cell anaemia

et al. 2015

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“…Rather, regular exercise is associated with attenuated inflammatory responses to exercise in individuals who are healthy or have chronic inflammation . Recent studies also suggest that aerobic exercise reduces oxidative stress and endothelial activation in sickle cell mice …”

Section: Discussionmentioning

confidence: 99%

Feasibility and safety of home exercise training in children with sickle cell anemia

Liem

Akinosun

Muntz

et al. 2017

Pediatric Blood & Cancer

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Exercise guidelines do not exist for individuals with sickle cell anemia (SCA) despite the impact of disease-related complications on physical functioning. Thirteen subjects (mean 15.1 ± 2.8 years old) with SCA were prescribed three exercise sessions/week for 12 weeks on a stationary bicycle placed at home. In total, 77% of subjects completed 89% of prescribed sessions without exercise-related adverse events, thus meeting feasibility and safety criteria. Adherence to prescribed duration and target heart rate during training decreased during the second half of the study. Future trials are warranted to further evaluate training benefits associated with regular exercise in children with SCA.

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“…Greater inflammation in SAD PA mice could be problematic by increasing the risks for vaso-occlusive events to occur. However, another recent study showed improvement of pulmonary endothelial function in trained versus sed SAD mice [7], which could counterbalance the effects of PA on WBCs count and platelet reactivity.…”

Section: Chronic Physical Activity Limits Blood Rheology Alterations mentioning

confidence: 93%

Chronic physical activity limits blood rheology alterations in transgenic SAD mice

et al. 2015

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Physical activity limits pulmonary endothelial activation in sickle cell SAD mice

Cited by 16 publications

References 10 publications

The acute phase inflammatory response to maximal exercise testing in children and young adults with sickle cell anaemia

The acute phase inflammatory response to maximal exercise testing in children and young adults with sickle cell anaemia

Feasibility and safety of home exercise training in children with sickle cell anemia

Chronic physical activity limits blood rheology alterations in transgenic SAD mice

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