Chronic physical activity limits blood rheology alterations in transgenic SAD mice

Faes, Camille; Charrin, Emmanuelle; Connes, Philippe; Pialoux, Vincent; Martin, Cyril

doi:10.1002/ajh.23896

Cited by 15 publications

(13 citation statements)

References 7 publications

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“…() observed that, after a VOC, regular physical activity was associated with a shorter duration of hospitalization. Based on studies conducted in SCD mice, this beneficial effect of endurance training could be explained by improvements in several vascular, haemorheological, inflammatory, endothelial activation and oxidative stress parameters (Aufradet et al., ; Charrin et al., ; Faes, Charrin, Connes, Pialoux, & Martin, ; Martin et al., ). In a recent study conducted in SCD mice, Charrin et al.…”

Section: Handling Of Blood Acidosis and Reduction Of Risk Of Vaso‐occmentioning

confidence: 99%

Do we have to consider acidosis induced by exercise as deleterious in sickle cell disease?

Chatel

Messonnier

Bendahan

2018

Experimental Physiology

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Sickle cell disease (SCD) is an inherited haemoglobin (Hb) disorder and the most common monogenic disease in the world. The root cause of this pathology is the synthesis of an abnormal Hb (HbS) that polymerizes in deoxygenated conditions, leading to the sickling of red blood cells. Acidosis is well recognized as a promoter of HbS polymerization and therefore red blood cell sickling. Indeed, it has been shown in vitro that the relative amount of sickled red blood cells increases markedly from 1% at pH 7.4 to >90% at pH 7.0. Nevertheless, no study has directly tested whether exercise-induced acidosis could favour SCD complications. Greater knowledge of the effects of metabolic acidosis during exercise could be of importance given the conclusions reached in several studies that proposed regular physical exercise as a therapeutic strategy in the management of SCD. In this review, we discuss the potential consequences of exercise-induced acidosis for the pathophysiology of SCD. We also propose some potential therapeutic interventions with the aim of reducing the metabolic acidosis related to exercise.

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Section: Handling Of Blood Acidosis and Reduction Of Risk Of Vaso‐occmentioning

confidence: 99%

Do we have to consider acidosis induced by exercise as deleterious in sickle cell disease?

Chatel

Messonnier

Bendahan

2018

Experimental Physiology

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“…12 Recent studies also suggest that aerobic exercise reduces oxidative stress and endothelial activation in sickle cell mice. [13][14][15] This study was limited by reduced adherence to training in the second half of the program, which may explain why peak VO 2 and other exercise parameters did not significantly improve at the end of study.…”

Section: Discussionmentioning

confidence: 97%

“…Rather, regular exercise is associated with attenuated inflammatory responses to exercise in individuals who are healthy or have chronic inflammation . Recent studies also suggest that aerobic exercise reduces oxidative stress and endothelial activation in sickle cell mice …”

Section: Discussionmentioning

confidence: 99%

Feasibility and safety of home exercise training in children with sickle cell anemia

Liem

Akinosun

Muntz

et al. 2017

Pediatric Blood & Cancer

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Exercise guidelines do not exist for individuals with sickle cell anemia (SCA) despite the impact of disease-related complications on physical functioning. Thirteen subjects (mean 15.1 ± 2.8 years old) with SCA were prescribed three exercise sessions/week for 12 weeks on a stationary bicycle placed at home. In total, 77% of subjects completed 89% of prescribed sessions without exercise-related adverse events, thus meeting feasibility and safety criteria. Adherence to prescribed duration and target heart rate during training decreased during the second half of the study. Future trials are warranted to further evaluate training benefits associated with regular exercise in children with SCA.

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“…Diaw et al 117 compared the blood viscosities of sedentary and trained SCT carriers, and found lower values in the second group. In another study, Faes et al 118 subjected a group of sickle mice (transgenic SAD model) to regular physical activity (voluntary wheel activity running) and observed a decrease in blood viscosity compared to that seen in their sedentary counterparts. Since elevated blood viscosity is a risk factor for VOC,13 95 one may hypothesise that regular activity could limit the risk of VOC in SCD.…”

Section: Regular Activity In Scdmentioning

confidence: 99%

Does physical activity increase or decrease the risk of sickle cell disease complications?

et al. 2015

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Sickle cell disease (SCD) is the most common inherited disease in the world. Red blood cell sickling, blood cell-endothelium adhesion, blood rheology abnormalities, intravascular haemolysis, and increased oxidative stress and inflammation contribute to the pathophysiology of SCD. Because acute intense exercise may alter these pathophysiological mechanisms, physical activity is usually contra-indicated in patients with SCD. However, recent studies in sickle-cell trait carriers and in a SCD mice model show that regular physical activity could decrease oxidative stress and inflammation, limit blood rheology alterations and increase nitric oxide metabolism. Therefore, supervised habitual physical activity may benefit patients with SCD. This article reviews the literature on the effects of acute and chronic exercise on the biological responses and clinical outcomes of patients with SCD.

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Chronic physical activity limits blood rheology alterations in transgenic SAD mice

Cited by 15 publications

References 7 publications

Do we have to consider acidosis induced by exercise as deleterious in sickle cell disease?

Do we have to consider acidosis induced by exercise as deleterious in sickle cell disease?

Feasibility and safety of home exercise training in children with sickle cell anemia

Does physical activity increase or decrease the risk of sickle cell disease complications?

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