“…Given that muscle exercise is tightly linked to intra‐ and extracellular acidosis resulting from the non‐oxidative glycolytic processes of energy production (Bangsbo et al., ; Bangsbo, Johansen, Graham, & Saltin, ; Brooks, ; Ferguson et al., ; Hermansen & Osnes, ; Juel, ; Marcinek, Kushmerick, & Conley, ; Osnes & Hermansen, ; Sahlin, ; Sahlin, Alvestrand, Brandt, & Hultman, ; Sahlin, Harris, Nylind, & Hultman, ), one can wonder whether physical activity could be deleterious for SCD patients. To prevent the occurrence of any associated risks, extending our knowledge about the potential deleterious effects of muscle exercise in SCD patients is of great interest, particularly given that rehabilitation based on physical activity is increasingly considered as a potential therapeutic strategy in this pathology (Liem, Akinosun, Muntz, & Thompson, ; Martin et al., ). In addition, in a recent study, an acid–base imbalance has been reported in exercising SCD mice, suggesting that the metabolic acidosis related to exercise could be exacerbated in SCD (Chatel et al., ).…”