Physical activity is associated with decreased global DNA methylation in Swedish older individuals

Luttropp, Karin; Nordfors, Louise; Ekström, Tomas J.; Lind, Lars

doi:10.3109/00365513.2012.743166

Cited by 37 publications

(30 citation statements)

References 9 publications

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“…A study by Zhang et al (17) also found that a high fruit and vegetable intake was associated with high DNA methylation of LINE-1 in blood. In addition, higher LINE-1 DNA methylation was found in individuals with higher exercise concentrations in the same population (18) and in other studies (20,21), suggesting an increase in LINE-1 DNA methylation might be associated with healthy lifestyle habits. Future studies are needed to confirm these associations and to understand the importance of the biological mechanisms at play.…”

Section: Discussionmentioning

confidence: 91%

“…Specific dietary changes, such as fish oil intake, have been associated with the differential methylation of 27 specific CpG sites in a study of the YupÕik Alaskan natives (19). Other studies have found that increased physical activity during childhood is associated with higher DNA methylation of LINE-1; however, increased exercise frequency in the elderly has been related to lower global methylation as measured by the luminometric methylation assay (LUMA) (20,21). Most studies have found that current smoking is not related to changes in global DNA methylation, whereas alcohol consumption seems to be related to an increase in DNA methylation of CpG sites within CCGG sequences, but not in the LINE-1 promoter region in some studies (11,12,18,(22)(23)(24)(25)(26).…”

Section: Introductionmentioning

confidence: 97%

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Dietary Modifications, Weight Loss, and Changes in Metabolic Markers Affect Global DNA Methylation in Hispanic, African American, and Afro-Caribbean Breast Cancer Survivors,

Delgado‐Cruzata

Zhang²,

McDonald³

et al. 2015

The Journal of Nutrition

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 97%

Dietary Modifications, Weight Loss, and Changes in Metabolic Markers Affect Global DNA Methylation in Hispanic, African American, and Afro-Caribbean Breast Cancer Survivors,

Delgado‐Cruzata

Zhang²,

McDonald³

et al. 2015

The Journal of Nutrition

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show abstract

“…One study found that individuals with physical activity ~30 min/day had a significantly higher level of global genomic DNA methylation compared to those with physical activity ≤ 10 min/day [58]. A similar genome-wide study on elderly individuals found that DNA methylation was significantly correlated with self-reported activity level [59]. …”

Section: Relevant Environmental Factors and Dna Methylationmentioning

confidence: 99%

DNA methylation in Huntington’s disease: Implications for transgenerational effects

Thomas

2016

Neuroscience Letters

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Huntington’s disease (HD) is a devastating, neurodegenerative disorder caused by a CAG repeat mutation in the HTT gene. A growing body of evidence suggests that epigenetic modifications play a key role in HD pathogenesis. Expression of the disease protein, huntingtin, leads to extensive transcriptional dysregulation due to disruption of histone-modifying complexes and altered interactions with chromatin-related factors. Such epigenetic mechanisms also readily respond to environmental factors, which are now thought to influence the risk, onset and progression of neurodegenerative disorders, including HD. DNA methylation is an epigenetic modification that has been studied intensively, however, its role in HD is just emerging. In this review, DNA methylation differences associated with HD will be summarized, as well as the role of environmental factors to alter DNA methylation in a manner that could alter disease phenotypes. Further, transgenerational epigenetic inheritance will be discussed in the context of relevant environmental factors and their potential links to HD. The study of epigenetic states in HD presents an opportunity to gain new insights into risk factors and pathogenic mechanisms associated with HD, as well as to inform about treatment options.

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“…29 A study of older adults (n=1016) found that levels of recent physical activity were inversely correlated with global methylation. 30 …”

Section: Introductionmentioning

confidence: 99%

Recreational and household physical activity at different time points and DNA global methylation

White

Sandler

Bolick

et al. 2013

European Journal of Cancer

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Background DNA methylation patterns are heritable but can change over time and in response to exposures. Lower global DNA methylation, which may result in increased genomic and chromosomal instability, has been associated with increased cancer risk. Physical activity is a modifiable factor that has been inversely related to the risk of cancer. Changes in DNA methylation may be a mechanism by which lifestyle and environment factors influence disease. We investigated the relationship between DNA methylation and physical activity in a sample of women enrolled in The Sister Study, a large U.S. cohort study of women aged 35–74 years with a family history of breast cancer. Methods Global DNA methylation was measured using bisulfite converted DNA and pyrosequencing of a LINE-1 repetitive sequence in the peripheral blood of 647 non-Hispanic white women. Physical activity (average hours per week) was retrospectively assessed for three time periods: childhood (ages 5–12), teenage years (ages 13–19) and the previous twelve months. Findings Compared with women with physical activity levels below the median for all three time periods, those at or above the median physical activity for one (β= 0.20, 95% CI: −0.10, 0.49), two (β= 0.22, 95% CI: −0.08, 0.52) or all three (β= 0.33, 95% CI: 0.01, 0.66) time periods had increased global methylation. Interpretation Maintaining higher levels of physical activity over these three time periods was associated with increased global DNA methylation, consistent with reported associations between exercise and decreased cancer risk.

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Physical activity is associated with decreased global DNA methylation in Swedish older individuals

Cited by 37 publications

References 9 publications

Dietary Modifications, Weight Loss, and Changes in Metabolic Markers Affect Global DNA Methylation in Hispanic, African American, and Afro-Caribbean Breast Cancer Survivors,

Dietary Modifications, Weight Loss, and Changes in Metabolic Markers Affect Global DNA Methylation in Hispanic, African American, and Afro-Caribbean Breast Cancer Survivors,

DNA methylation in Huntington’s disease: Implications for transgenerational effects

Recreational and household physical activity at different time points and DNA global methylation

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