Dietary Modifications, Weight Loss, and Changes in Metabolic Markers Affect Global DNA Methylation in Hispanic, African American, and Afro-Caribbean Breast Cancer Survivors,

Delgado‐Cruzata, Lissette; Zhang, Wenfei; McDonald, Jasmine A.; Tsai, Wei Yann; Valdovinos, Cristina; Falci, Laura; Wang, Qiao; Crew, Katherine D.; Santella, Regina M.; Hershman, Dawn L.; Greenlee, Heather

doi:10.3945/jn.114.202853

Cited by 60 publications

(52 citation statements)

References 58 publications

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“…A growing body of literature suggests that high fruit/vegetable intake may be associated with high DNA methylation of LINE-1 (55–57). In addition, increased LINE-1 DNA methylation is associated with decreased genomic instability and less frequent nucleic acid sequence changes or chromosomal rearrangements (58, 59), which are important biological mechanisms underlying the cancer development and progression.…”

Section: Discussionmentioning

confidence: 99%

Long-term Diet and Biomarker Changes after a Short-term Intervention among Hispanic Breast Cancer Survivors: The¡Cocinar Para Su Salud!Randomized Controlled Trial

Greenlee

Gaffney²,

Aycinena

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Among Hispanic breast cancer (BC) survivors, we examined the long-term effects of a short-term culturally-based dietary intervention on increasing fruits/vegetables (F/V), decreasing fat and changing biomarkers associated with BC recurrence risk. Methods Spanish-speaking women (n=70) with a history of stage 0-III BC who completed treatment were randomized to ¡Cocinar Para Su Salud! (n=34), a culturally-based 9-session program (24 hours over 12 weeks, including nutrition education, cooking classes, and food-shopping field trips), or a control group (n=36, written dietary recommendations for BC survivors). Diet recalls, fasting blood, and anthropometric measures were collected at baseline, 6, and 12 months. We report changes between groups at 12 months in dietary intake and biomarkers using 2-sample Wilcoxon t-tests and Generalized Estimating Equation (GEE) models. Results At 12 months, the intervention group compared to the control group reported higher increases in mean daily F/V servings (total: +2.0 vs. −0.4; P=0.006), and non-significant decreases in percent calories from fat (−2.2% vs. −1.1%; P=0.69) and weight (−2.6 kg vs. −1.5 kg; P=0.56). Compared to controls, participants in the intervention group had higher increases in plasma lutein (+20.4% vs. −11.5%; P=0.002), and borderline significant increases in global DNA methylation (+0.8% vs. −0.5%; P=0.06). Conclusions The short-term ¡Cocinar Para Su Salud! program was effective at increasing long-term F/V intake in Hispanic BC survivors and changed biomarkers associated with BC recurrence risk. Impact It is possible for short-term behavioral interventions to have long-term effects on behaviors and biomarkers in minority cancer patient populations. Results can inform future study designs.

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Section: Discussionmentioning

confidence: 99%

Long-term Diet and Biomarker Changes after a Short-term Intervention among Hispanic Breast Cancer Survivors: The¡Cocinar Para Su Salud!Randomized Controlled Trial

Greenlee

Gaffney²,

Aycinena

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…This is evident in one study where obese individuals receive a 1.89 fold change in hypermethylation of BRCA1 based off of a BMI of 30kg/m2 versus healthy individuals [44]. This is a particular environmental factor that can be altered with a change in diet and exercise [48,49]. Even when proper BMI is achieved, there is an increase in global methylation, which indicates a healthy individual.…”

Section: Factors For Methylation Frequencies In Tnbcmentioning

confidence: 98%

Risk Factors contributing to Methylation Shifts in BRCA1 and associated genes in African Americans with Triple Negative Breast Cancer

Marsh¹,

Chandra²

2017

Med-Science

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Triple negative breast cancer (TNBC) remains one of the most lethal breast cancers while only accounting for 10-20% of all breast cancers. Mortality rates are a staggering 50%, with high likelihood of metastasis to other tissues if left untreated. This is due to this cancer's heterogeneous nature and differentiation from other breast cancers, negatively staining for common mutations in estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 (HER2). The patient population is shifted more towards African Americans (AA) with increased incidence and mortality rates. To date the nature of this statistic remains multifaceted with no clear therapeutic regiment. Through the identification of methylation as viable cause for TNBC, the exploration of environmental, genetic, and socioeconomic risk factors serve as an important aspect of overall mortality rate. This review seeks to investigate the relationship between AA with TNBC and potentially important DNA methylation markers that change in response to multiple risk factors.

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“…For example, changes in dietary habits including fruit intake have been positively associated with epigenetic modifications, such as changes in LINE-1 DNA methylation [50] or a lower prevalence of DNA hypomethylation, an association that was dose dependent [51]. Changes in the methylation levels of specific gene promoters may regulate the expression of genes by modifying the interaction of transcription factors and methyl-DNA-binding proteins [52].…”

Section: Discussionmentioning

confidence: 99%

Higher Fruit Intake Is Related to <b><i>TNF-α</i></b> Hypomethylation and Better Glucose Tolerance in Healthy Subjects

Carraro

Hermsdorff²,

Mansego³

et al. 2016

Lifestyle Genomics

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Background/Aim: This study hypothesized an association between healthy dietary patterns, hypermethylation of the tumor necrosis factor-α (TNF-α) promoter and decreased risk of metabolic changes. Methods: Forty normal-weight young women were involved in this cross-sectional study. DNA was isolated from white blood cells, and CpG site methylation in TNF-α was analyzed by Sequenom EpiTyper. The quality of the diet was assessed by Healthy Eating Index (HEI-2005). Results: Contradicting our hypothesis, HEI-2005 score was negatively associated with CpG5 (r = -0.460, p = 0.003) and TNF-α total methylation (r = -0.355, p = 0.026). A higher intake of fruits was related to lower insulin, HOMA-IR, and TNF-α methylation. No other dietary pattern was related to TNF-α methylation. TNF-α total methylation correlated positively with systolic blood pressure (r = 0.323; p = 0.042) and CpG5 methylation with body mass index (r = 0.333, p = 0.036). Furthermore, fiber intake was negatively associated with the CpG5 (r = -0.324, p = 0.041) and TNF-α total methylation (r = -0.434, p = 0.005), whereas vitamin C intake was negatively associated with TNF-α total methylation (r = -0.411, p = 0.009). Intakes of apples and citrus fruits were negatively associated with TNF-α total methylation. Conclusion: A healthy dietary pattern and higher fruit intake (particularly apples and citrus fruits) were related to better glucose tolerance in healthy subjects, which could be mediated by lower TNF-α methylation.

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Dietary Modifications, Weight Loss, and Changes in Metabolic Markers Affect Global DNA Methylation in Hispanic, African American, and Afro-Caribbean Breast Cancer Survivors,

Cited by 60 publications

References 58 publications

Long-term Diet and Biomarker Changes after a Short-term Intervention among Hispanic Breast Cancer Survivors: The¡Cocinar Para Su Salud!Randomized Controlled Trial

Long-term Diet and Biomarker Changes after a Short-term Intervention among Hispanic Breast Cancer Survivors: The¡Cocinar Para Su Salud!Randomized Controlled Trial

Risk Factors contributing to Methylation Shifts in BRCA1 and associated genes in African Americans with Triple Negative Breast Cancer

Higher Fruit Intake Is Related to <b><i>TNF-α</i></b> Hypomethylation and Better Glucose Tolerance in Healthy Subjects

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