Physical Activity for Individuals Living with Advanced Cancer: Evidence and Recommendations

Capozzi, L; Daun, Julia T.; Ester, Manuel; Mosca, Stephen J.; Langelier, David; Francis, George J.; Chang, Eugene; Mina, Daniel Santa; Fu, Jack B.; Culos‐Reed, S. Nicole

doi:10.1016/j.soncn.2021.151170

Cited by 16 publications

(11 citation statements)

References 39 publications

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“…First, cancer rehabilitation programs should encourage patients to engage in physical activities that can improve muscular strength (Al-Majid & Waters, 2008; Christensen et al, 2014). More detailed guidelines and information must be provided for adherence to rehabilitation and training of patients with cancer (Capozzi et al, 2021). For example, oncology nurses can specialize in providing care by monitoring health trajectories of patients with cancer, including treatment, survivorship, and palliation.…”

Section: Discussionmentioning

confidence: 99%

Understanding Heterogeneity in the Relationship Between Cancer and Hand Grip Strength: A Longitudinal Analysis

Kim

Park

2023

Res Aging

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This study examined whether the relationship between cancer and hand grip strength differs by sex and along the hand grip strength distribution. Using six waves of the Korean Longitudinal Study of Ageing (KLoSA) (N = 9735), sex-stratified unconditional quantile regression models with fixed effects were used to assess sex-specific effects of cancer for patients in different quantiles of the hand grip strength distribution. Cancer diagnosis was negatively associated with hand grip strength for males, but not females, and this sex difference was statistically significant. Quantile regression models showed that the stronger association between cancer and hand grip strength is observed among males with weaker hand grip strength. No statistically significant association was found between hand grip strength and cancer in females across the entire distribution of hand grip strength. This study provided evidence of the heterogeneity in the relationship between cancer and hand grip strength.

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Section: Discussionmentioning

confidence: 99%

Understanding Heterogeneity in the Relationship Between Cancer and Hand Grip Strength: A Longitudinal Analysis

Kim

Park

2023

Res Aging

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“…Understanding the extent of the boney metastasis allows for tailoring of exercise with the goal of improving overall conditioning, while avoiding excessive torque across the affected metastatic bone. Unlike osteoporotic bone, bone-loading does not increase bone integrity for those with boney metastasis [ 33 ]. Avoid any activities that cause bone pain and avoid resisted flexion and extension at the hip if metastatic disease is to the pelvis or femur.…”

Section: Exercise Prescription To Address Cancer-related Impairments:...mentioning

confidence: 99%

“…Avoid any activities that cause bone pain and avoid resisted flexion and extension at the hip if metastatic disease is to the pelvis or femur. Limit simultaneous bending and lifting or twisting and lifting if there is metastatic disease to the axial skeleton [ 33 ]. Instead, choose partial-weight-bearing activities, or assisted movements such as pull-ups, push-ups, or dips, if the patient does not have upper extremity metastasis.…”

Section: Exercise Prescription To Address Cancer-related Impairments:...mentioning

confidence: 99%

“…It is important to educate those with breast cancer on the role of exercise, as this can help to eliminate barriers and misinformation. Use a visual analogue scale (VAS) to measure fatigue before and after an exercise session, and aim for either the same or lower fatigue levels post-exercise [ 33 ]. In addition, measuring ‘energy’ levels with a VAS or a ‘thermometer’ style tool can be beneficial for ensuring that, both during and after an exercise session, energy is gained while fatigue is not enhanced (and may be improved).…”

Section: Exercise Prescription To Address Cancer-related Impairments:...mentioning

confidence: 99%

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Tailoring the Evidence for Exercise Oncology within Breast Cancer Care

2022

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Exercise is safe and effective for those living with and beyond breast cancer, with evidence supporting exercise guidelines, and position statements from international organizations. Despite the clearly recognized benefits of exercise for these individuals, many do not participate or maintain recommended exercise levels throughout the breast cancer continuum, highlighting the lack of translation from research into practice. In addition, discerning how exercise can be tailored to address breast cancer-related impairments, so that individuals are able to participate safely and effectively, has also not been studied extensively. Thus, we propose that implementing exercise screening, triage, and referral pathways across the breast cancer continuum may allow for increased accessibility and adoption among those living with and beyond breast cancer. This paper provides an overview of exercise prescription tailoring for common breast cancer and treatment-related impairments, proposes a simplified screening tool for identifying physical activity and movement-related impairments, and considers how best to channel evidence into practice via proposed implementation pathways that may better connect individuals living with and beyond breast cancer with exercise oncology resources through screening, triage, and referral.

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“…Although the precise mechanisms associated with CRF have yet to be identified, the driving factors are commonly theorized to be associated with negative physiological (i.e., muscle strength and endurance, cardiorespiratory fitness, body composition), biologic/hematologic (i.e., inflammatory response, metabolic/endocrine/immune function), psychological (i.e., anxiety, depression, distress), behavioral (i.e., sleep quality and quantity, appetite) and social (i.e., social interaction) changes resulting from cancer and its treatment [ 3 , 4 ]. Historically, patients have been advised to rest during and after cancer treatments; however, research evidence refutes the use of rest as an effective strategy to manage CRF due to the detrimental effects of inactivity on structure and function (i.e., negative adaptations in the neuromuscular, skeletal and cardiorespiratory systems) [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

The effects of home-based exercise therapy for breast cancer-related fatigue induced by radical radiotherapy

et al. 2022

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Background Radiotherapy (RT) can lead to cancer-related fatigue (CRF) and decreased health-related quality of life (HRQoL) in breast cancer patients. The purpose of this trial was to examine the feasibility and efficacy of a home-based resistance and aerobic exercise intervention for reducing CRF and improving HRQoL in breast cancer patients during RT. Methods Women with breast cancer (N = 106) commencing RT were randomized to 12 weeks of home-based resistance and aerobic exercise (EX) or usual care/control (CON). The primary endpoint was CRF, with secondary endpoints of HRQoL, sleep duration and quality, and physical activity. Measurements were undertaken prior to RT, at completion of RT (~ 6 weeks), at completion of the intervention (12 weeks), and 6 and 12 months after RT completion, while CRF was also measured weekly during RT. Results Eighty-nine women completed the study (EX = 43, CON = 46). Over the 12-week intervention, EX completed 1–2 resistance training sessions and accumulated 30–40 min of aerobic exercise weekly. For CRF, EX had a quicker recovery both during and post-RT compared to CON (p < 0.05). Moreover, there was a significant difference in HRQoL between groups at RT completion, with HRQoL unchanged in CON and higher in EX (p < 0.05). There was no change in sleep duration or quality for either group and there were no exercise-related adverse effects. Conclusions Home-based resistance and aerobic exercise during RT is safe, feasible, and effective in accelerating CRF recovery and improving HRQoL. Improvements in CRF and HRQoL for these patients can be achieved with smaller exercise dosages than stated in the generic recommendations for breast cancer.

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Physical Activity for Individuals Living with Advanced Cancer: Evidence and Recommendations

Cited by 16 publications

References 39 publications

Understanding Heterogeneity in the Relationship Between Cancer and Hand Grip Strength: A Longitudinal Analysis

Understanding Heterogeneity in the Relationship Between Cancer and Hand Grip Strength: A Longitudinal Analysis

Tailoring the Evidence for Exercise Oncology within Breast Cancer Care

The effects of home-based exercise therapy for breast cancer-related fatigue induced by radical radiotherapy

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