Understanding Heterogeneity in the Relationship Between Cancer and Hand Grip Strength: A Longitudinal Analysis

Kim, Jin Ho; Park, Gum‐Ryeong

doi:10.1177/01640275231170299

Cited by 2 publications

(1 citation statement)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To investigate the heterogeneity in the relationship between marital satisfaction and cognitive function across the cognitive function distribution, we estimate UQR models using an individual FE approach to account for individual-level heterogeneity ( Borgen, 2016 ; Kim & Park, 2023b ). This method provides consistent estimates of the effect of marital satisfaction on cognitive function at virtually any quantile of the unconditional distribution, and can help reveal heterogeneity that may be obscured by conventional FE models.…”

Section: Methodsmentioning

confidence: 99%

Investigating Heterogeneity in the Relationship Between Marital Satisfaction and Cognitive Health by Gender and Across the Cognitive Function Distribution

Kim

Kwon

2023

Innovation in Aging

Self Cite

View full text Add to dashboard Cite

Background and Objectives Marital satisfaction has been established as an essential factor for promoting health and well-being in older adults. However, it is unclear whether marital satisfaction is also associated with cognitive health in this population. This study aimed to investigate the longitudinal association between marital satisfaction and cognitive function, while also exploring variations in this relationship by gender and across the cognitive function distribution. Research Design and Methods This study used six waves of the Korean Longitudinal Study of Ageing (KLoSA) and employed gender-stratified unconditional quantile regression (UQR) models with fixed effects (FE) to estimate the association between marital satisfaction and cognitive function across different quantiles of the cognitive function distribution. FE models controlled for unobserved individual-level confounders such as genetics, cognitive and non-cognitive skills, and early childhood social and cultural background. Results The results of this study revealed that marital satisfaction was positively associated with cognitive function (b = 0.305), and this association was stronger in older men than in older women (b = 0.392 for older men vs. b = 0.181 for older women). The UQR-FE models suggested that the stronger association between marital satisfaction and cognitive function was observed among older men with lower cognitive function (b = 0.817 for 10th percentile vs. b = 0.118 for 90th percentile). Among older women, no clear patterns of heterogeneity were found across the cognitive function distribution. Discussion and Implications The findings of this study highlight a significant degree of heterogeneity in the relationship between marital satisfaction and cognitive function among older men, with the stronger associations observed in the lower percentiles of the cognitive function distribution. Interventions aimed at improving marital quality could be an effective strategy for promoting cognitive health in older adults, with an approach tailored to the individual’s characteristics.

show abstract

Section: Methodsmentioning

confidence: 99%

Investigating Heterogeneity in the Relationship Between Marital Satisfaction and Cognitive Health by Gender and Across the Cognitive Function Distribution

Kim

Kwon

2023

Innovation in Aging

Self Cite

View full text Add to dashboard Cite

show abstract

Exploring heterogeneity: a dive into preclinical models of cancer cachexia

Morena,

Cabrera,

Greene

2024

American Journal of Physiology-Cell Physiology

View full text Add to dashboard Cite

Cancer Cachexia (CC) is a multifactorial and complex syndrome experienced by up to 80% of cancer patients and implicated in ~40% of cancer-related deaths. Given its significant impact on patients' quality of life and prognosis, there has been a growing emphasis on elucidating the underlying mechanisms of CC using pre-clinical models. However, the mechanisms of cachexia appear to differ across several variables including tumor type and model and biologic variables such as sex. These differences may be exacerbated by variance in experimental approaches and data reporting. This review examines literature spanning from 2011 to March 2024, focusing on common pre-clinical models of CC, including Lewis Lung Carcinoma, pancreatic KPC, and colorectal colon-26 and Apcmin/+ models. Our analysis reveals considerable heterogeneity in phenotypic outcomes, and investigated mechanisms within each model, with particular attention to sex differences which may be exacerbated through methodological differences. While searching for unified mechanisms is critical, we posit that effective treatment approaches are likely to leverage the heterogeneity presented by the tumor and pertinent biological variables to direct specific interventions. In exploring this heterogeneity, it becomes critical to consider methodological and data reporting approaches to best inform further research.

show abstract

Understanding Heterogeneity in the Relationship Between Cancer and Hand Grip Strength: A Longitudinal Analysis

Cited by 2 publications

References 36 publications

Investigating Heterogeneity in the Relationship Between Marital Satisfaction and Cognitive Health by Gender and Across the Cognitive Function Distribution

Investigating Heterogeneity in the Relationship Between Marital Satisfaction and Cognitive Health by Gender and Across the Cognitive Function Distribution

Exploring heterogeneity: a dive into preclinical models of cancer cachexia

Contact Info

Product

Resources

About