Physical Activity, Biomarkers, and Disease Outcomes in Cancer Survivors: A Systematic Review

Ballard‐Barbash, Rachel; Friedenreich, Christine M.; Courneya, Kerry S.; Siddiqi, Sameer; McTiernan, Anne; Alfano, Catherine M.

doi:10.1093/jnci/djs207

Cited by 730 publications

(578 citation statements)

References 66 publications

Supporting

Mentioning

550

Contrasting

Unclassified

Order By: Relevance

“…In the present study, it was demonstrated that the protein expression level of MMP2 was notably decreased following miR-766-5p inhibitor treatment compared to that following treatment with the NC. Additionally, the PI3K/AKT/mammalian target of rapamycin pathway was reported to be a potential target for prevention of CRC (29,30). In the present study, protein expression levels of p-PI3K and p-AKT were also found to be markedly decreased following miR-766-5p inhibitor treatment compared to the levels in the NC group.…”

Section: Discussionsupporting

confidence: 58%

The role of miR-766-5p in cell migration and invasion in colorectal cancer

2018

View full text Add to dashboard Cite

Abstract. Colorectal cancer (CRC) develops from the colon or rectum and is the fourth highest inducer of cancer mortality. In the present study, cancer tissues and normal tissues were extracted from patients with CRC who were treated in the Affiliated Hospital of Shandong University of Traditional Chinese Medicine (Jinan, China). Reverse transcription-quantitative polymerase chain reaction demonstrated that the expression level of miR-766-5p was significantly higher (P<0.01) in cancer tissue than that in normal tissue. SW480 cells were used for in vitro study and randomly separated into the miR-negative control (NC) inhibitor treatment group and miR-766-5p inhibitor treatment group. SW480 cell behaviors were evaluated. Results demonstrated that in the miR-766-5p inhibitor group, there was a decreased level of cell proliferation/migration/invasion and higher cell apoptosis compared with that in the miR-NC inhibitor group. miR-766-5p was predicted and verified to target the 3' untranslated region of suppressor of cancer cell invasion (SCAI) in SW480 cells. Protein expression levels of matrix metalloproteinase-2/phosphoinositide 3-kinase/AKT were decreased and SCAI was increased following miR-766-5p inhibitor treatment. In conclusion, the present study indicated that miR-766-5p inhibitor repressed the process of CRC by targeting SCAI.

show abstract

Section: Discussionsupporting

confidence: 58%

The role of miR-766-5p in cell migration and invasion in colorectal cancer

2018

View full text Add to dashboard Cite

show abstract

“…Based on more than 250 epidemiological studies it was concluded that physical activity is convincingly associated with reduced risk of breast and colon cancer but possibly also contributes to a lower risk of endometrial, lung and prostate cancer [75]. Ballard-Barbas and co-workers from NIH, USA [76] concluded in a systematic review that there is consistent evidence that physical activity is associated with reduced breast and colon cancer-specific mortality in cancer survivors. For other kinds of cancer the evidence is still insufficient.…”

Section: Physical Activity and Cancermentioning

confidence: 99%

Healthy aging and age-adjusted nutrition and physical fitness

Hammar

Östgren

2013

Best Practice & Research Clinical Obstetrics & Gynaecol

View full text Add to dashboard Cite

(154 words)The expected life span is gradually increasing worldwide. For healthy ageing there are a number of options that may be used including healthy dietary and exercise habits. To reduce or prevent obesity certain types of diet may be used that will also reduce the risk of, e.g., cardiovascular disease (CVD). Exercise reduces the risk of diseases like CVD, osteoporosis, some cancers and some mental disturbances. Decreasing a sedentary life style seems at least as important as regular exercise. Exercise can probably be tailored to reduce the risk of CVD and extent of bone loss. To insure adherence, it is important to slowly increase the frequency, duration and intensity of exercise and to find activities that suit the individual. More research has to be done in order to find the ideal modes and doses of exercise and to increase long-term adherence. Both dietary and exercise modification seem to be strong promoters of healthy ageing.Healthy aging and age adjusted nutrition and physical fitness Hammar M, Östgren CJ

show abstract

“…Several observational studies have indicated that women who engage in regular exercise after a diagnosis of stage I to III breast cancer experience a lower risk of breast cancer recurrence and related mortality. [1][2][3] In addition, >100 interventional trials have been conducted in women with early-stage breast cancer. [4][5][6] Although no trial to date has been large enough to test the impact of increased exercise on cancer-related outcomes, these studies have demonstrated that exercise is safe and provides several health benefits in patients with breast cancer both during and after adjuvant therapy.…”

Section: Introductionmentioning

confidence: 99%

Randomized trial of a physical activity intervention in women with metastatic breast cancer

Ligibel

Giobbie‐Hurder

Shockro

et al. 2016

Cancer

189

View full text Add to dashboard Cite

BACKGROUND: Exercise interventions improve fitness, functional capacity, and quality of life in patients with early-stage breast cancer, but to the authors' knowledge there are few data regarding the feasibility or potential benefits of exercise in women with metastatic breast cancer. METHODS: Individuals with metastatic breast cancer were randomized 1:1 to a 16-week moderate-intensity exercise intervention or wait-list control group. Intervention goals included 150 minutes of moderate-intensity aerobic exercise per week. The baseline and 16-week evaluations included a modified Bruce Ramp treadmill test, 7-day Physical Activity Recall interview, and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ C-30) questionnaire. RESULTS: A total of 101 participants were randomized (48 to the intervention group and 53 to the control group). The median age of the participants was 49 years, the median time since the diagnosis of metastatic breast cancer was 1.1 years, and approximately 42% of participants were undergoing chemotherapy at the time of enrollment. Study attrition was higher in the intervention arm (14 participants vs 8 participants; P 5 .15). Women randomized to the exercise intervention experienced a nonsignificant increase with regard to minutes of weekly exercise ( INTRODUCTIONOver the past decade, the benefits of exercise have increasingly been demonstrated for women with early breast cancer. Several observational studies have indicated that women who engage in regular exercise after a diagnosis of stage I to III breast cancer experience a lower risk of breast cancer recurrence and related mortality.1-3 In addition, >100 interventional trials have been conducted in women with early-stage breast cancer. [4][5][6] Although no trial to date has been large enough to test the impact of increased exercise on cancer-related outcomes, these studies have demonstrated that exercise is safe and provides several health benefits in patients with breast cancer both during and after adjuvant therapy.Despite these data in women with early-stage breast cancer, to our knowledge there is little information regarding the feasibility or benefits of exercise in women with advanced breast cancer. With new treatments, women often live several years after a diagnosis of metastatic breast cancer. However, during this time, many women experience significant side effects from breast cancer treatment, as well as symptoms from their disease. Fatigue, poor physical functioning, pain, and other symptoms can impair a woman's ability to complete activities of daily living in the years after the diagnosis of metastatic breast cancer, which in turn significantly compromises quality of life (QOL) and mood. Interventions are needed to help alleviate symptoms and allow women to continue to function normally in the years that they survive with advanced breast cancer.

show abstract

Physical Activity, Biomarkers, and Disease Outcomes in Cancer Survivors: A Systematic Review

Cited by 730 publications

References 66 publications

The role of miR-766-5p in cell migration and invasion in colorectal cancer

The role of miR-766-5p in cell migration and invasion in colorectal cancer

Healthy aging and age-adjusted nutrition and physical fitness

Randomized trial of a physical activity intervention in women with metastatic breast cancer

Contact Info

Product

Resources

About