Physical activity and the risk of breast cancer in BRCA1/2 mutation carriers

Pijpe, Anouk; Manders, Peggy; Brohet, Richard M.; Collée, J. Margriet; Verhoef, Senno; Vasen, Hans F. A.; Hoogerbrugge, Nicoline; Asperen, Christi J. van; Dommering, Charlotte J.; Ausems, Margreet G. E. M.; Aalfs, Cora M.; Gómez-García, Encarna B.; Veer, Laura J. van’t; Leeuwen, Flora E. van; Rookus, Matti A.

doi:10.1007/s10549-009-0476-0

Cited by 77 publications

(64 citation statements)

References 38 publications

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“…Sample size calculation: There is some evidence to suggest an association between BMI and breast cancer incidence in BRCA mutation carriers [19][20][21] and even stronger evidence to suggest an association with sporadic breast cancer [7]. Therefore BMI was the chosen outcome on which the power analysis is based.…”

Section: Discussionmentioning

confidence: 99%

IFNL cytokines do not modulate human or murine NK cell functions

Morrison¹,

Keane²,

Quinn³

et al. 2014

Human Immunology

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Background: Breast cancer is the most common female cancer worldwide. The lifetime risk of a woman being diagnosed with breast cancer is approximately 12.5%. For women who carry the deleterious mutation in either of the BRCA genes, BRCA1 or BRCA2, the risk of developing breast or ovarian cancer is significantly increased. In recent years there has been increased penetrance of BRCA1 and BRCA2 associated breast cancer, prompting investigation into the role of modifiable risk factors in this group. Previous investigations into this topic have relied on participants recalling lifetime weight changes and subjective methods of recording physical activity. The influence of obesity-related biomarkers, which may explain the link between obesity, physical activity and breast cancer risk, has not been investigated prospectively in this group. This paper describes the design of a prospective cohort study investigating the role of predictive and modifiable risk factors for breast cancer in unaffected BRCA1 and BRCA2 gene mutation carriers. Methods/design: Participants will be recruited from breast cancer family risk clinics and genetics clinics. Lifestyle risk factors that will be investigated will include body composition, metabolic syndrome and its components, physical activity and dietary intake. PBMC telomere length will be measured as a potential predictor of breast cancer occurrence. Measurements will be completed on entry to the study and repeated at two years and five years. Participants will also be followed annually by questionnaire to track changes in risk factor status and to record cancer occurrence. Data will be analysed using multiple regression models. The study has an accrual target of 352 participants.

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Section: Discussionmentioning

confidence: 99%

IFNL cytokines do not modulate human or murine NK cell functions

Morrison¹,

Keane²,

Quinn³

et al. 2014

Human Immunology

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show abstract

“…The present study was conducted within the framework of the HEBON study, of which the design was described earlier [23]. In brief, the HEBON study is an ongoing nationwide retrospective cohort study with prospective follow-up among members of BRCA1/2 families in the Netherlands.…”

Section: Study Populationmentioning

confidence: 99%

“…The association between obesity and poor prognosis of breast cancer was present in both pre-and postmenopausal carriers. To reduce (potential) survival bias, we restricted the analysis to person-years within 10 years prior to questionnaire completion [23,[30][31][32]. We excluded cases who died a long time ago whose prognosis might have been influenced by BMI.…”

Section: Analytic Cohortmentioning

confidence: 99%

Body weight and risk of breast cancer in BRCA1/2 mutation carriers

Manders

Pijpe²,

Hooning

et al. 2010

Breast Cancer Res Treat

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Obesity is an established risk factor for postmenopausal breast cancer in the general population. However, it is still unclear whether this association also exists in BRCA1/2 mutation carriers. We investigated the association between self-reported anthropometric measures and breast cancer risk in a nationwide retrospective cohort study, including 719 BRCA1/2 carriers, of whom 218 had been diagnosed with breast cancer within 10 years prior to questionnaire completion. All time-varying Cox proportional hazards analyses were stratified by menopausal status. For premenopausal breast cancer, no statistically significant associations were observed for any of the anthropometric measures. The association between body mass index (BMI) at age 18 and premenopausal breast cancer risk suggested a trend of decreasing risk with increasing BMI 123Breast Cancer Res Treat (2011) 126:193-202 DOI 10.1007/s10549-010-1120 5 kg or more, and a relative adult weight gain of 20% or more were all non-significantly associated with a 50-60% increased risk of postmenopausal breast cancer [HR = 1.46 (0.86-2.51), HR = 1.56 (95% CI = 0.85-2.87), and HR = 1.60 (95% CI = 0.97-2.63), respectively], when compared with having a healthy or stable weight. No associations for body weight or BMI at age 18 were observed. In conclusion, menopausal status seemed to modify the association between body weight and breast cancer risk among BRCA1/2 carriers. We observed no clear association between body weight and premenopausal breast cancer, while overweight and weight gain increased postmenopausal breast cancer risk. Carriers may reduce their risk of postmenopausal breast cancer by maintaining a healthy body weight throughout life.

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“…Worthwhile lifestyle adaptations include an increase in physical activity [86], low fat diet and management of obesity.…”

Section: Medical Preventionmentioning

confidence: 99%

Screening for gynaecologic cancers in genetically predisposed women

Dreyer

2012

Best Practice & Research Clinical Obstetrics & Gynaecol

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Hereditary breast and ovarian cancer (HBOC) syndrome and hereditary nonpolyposis colon cancer (HNPCC) syndrome are the two most important syndromes responsible for inherited cancers in gynaecology. Genetic testing is available for both these syndromes. BRCA testing is affordable and easy in patients with ancestry where the mutation patterns are known, other population groups need full gene screening. HNPCC can now be diagnosed more frequently with the use of immunohistochemistry.Ovarian cancer risk is high in HBOC syndromes and advanced screening techniques should be used when preventive surgery is not an option. Early detection techniques offer less protection than prophylactic removal, but enable the patient to retain her reproductive organs. Oophorectomy has the advantage of reducing breast cancer risk.In colorectal cancer syndromes the risk for endometrial and ovarian cancer is much elevated. These risks should be recognised and addressed as these diseases are easy to prevent.

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Physical activity and the risk of breast cancer in BRCA1/2 mutation carriers

Cited by 77 publications

References 38 publications

IFNL cytokines do not modulate human or murine NK cell functions

IFNL cytokines do not modulate human or murine NK cell functions

Body weight and risk of breast cancer in BRCA1/2 mutation carriers

Screening for gynaecologic cancers in genetically predisposed women

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