“…For example, in Polish high-school students, regular physical activity was negatively associated with cigarette and marijuana use in males, but not females (7); whereas, in Slovak and Czech high-school students, physical activity was negatively associated with cigarette and marijuana use in females, but not males (4,6). While socio-cultural factors likely contribute these differential effects (20), levels of exercise/physical activity also differ between males and females and populations (4,6–7); thus, exercise may interact with socio-cultural factors to differentially influence the use to drugs in males versus females within different populations.…”