Physical activity and risk of cardiovascular disease

Li, Jian; Loerbroks, Adrian; Angerer, Peter

doi:10.1097/hco.0b013e328364289c

Cited by 176 publications

(87 citation statements)

References 46 publications

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“…Based on our analyses using dichotomized or continuous measures for PA, our study did not confirm the accumulated evidence on and the long-held belief in the cardioprotective effect of LTPA, at least not among working middle-aged men (21,57). Based on our sensitivity analysis of trichotomized PA measures, mixed results were found for the impact of high levels of LTPA: it appeared to decrease AMI risk for men at low OPA and with IHD, increase AMI risk for men at moderate OPA (regardless of IHD status, and up to 2.58-fold, 95% CI 1.03-6.45 among men with IHD), or have no effect on AMI at high OPA level.…”

Section: Effects Of Ltpa Accounting For Opamentioning

confidence: 43%

“…Another explanation could be that high and exhausting levels of OPA preclude workers from engaging in LTPA (20); thus, these workers cannot benefit from LTPA. Finally, OPA could directly affect CVD (21). Based on the negative correlation between OPA and LTPA observed in previous work (14) and previous observations that LTPA participation was relatively low among blue-collar workers (22), we hypothesized that LTPA would both interact with OPA and mediate the effect of OPA on CVD.…”

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confidence: 99%

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Effects of leisure-time and occupational physical activities on 20-year incidence of acute myocardial infarction: mediation and interaction

Wang¹,

Arah²,

Kauhanen³

et al. 2016

Scand J Work Environ Health

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High occupational physical activity (OPA) increased acute myocardial infarction (AMI) risk among workers with and without preexisting ischemic heart disease (IHD), however consistently only at low levels of leisure-time physical activity (LTPA). Workers with high OPA and low LTPA and workers with high LTPA and moderate OPA had the highest risks for AMI. LTPA did not mediate the impact of OPA on AMI risk. Affiliation:

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Section: Effects Of Ltpa Accounting For Opamentioning

confidence: 43%

mentioning

confidence: 99%

Effects of leisure-time and occupational physical activities on 20-year incidence of acute myocardial infarction: mediation and interaction

Wang¹,

Arah²,

Kauhanen³

et al. 2016

Scand J Work Environ Health

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“…Physical inactivity is a well‐known risk factor for cardiovascular disease (CVD)1, 2 and premature mortality from CVD 2, 3, 4. One explanation for these findings is thought to be because of beneficial effects of physical activity (PA) on endothelial function and the relatively less well‐studied biomarkers of atherosclerosis 5, 6, 7, 8, 9, 10, 11, 12.…”

Section: Introductionmentioning

confidence: 99%

Physical Activity, Sedentary Time, and Cardiovascular Disease Biomarkers at Age 60 to 64 Years

Elhakeem

Cooper

Whincup

et al. 2018

JAHA

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BackgroundWe examined associations of objectively measured physical activity (PA) and sedentary time with cardiovascular disease biomarkers at age 60 to 64 years. This included investigation of sex differences and the extent to which associations may be mediated by adiposity.Methods and ResultsParticipants were 795 men and 827 women aged 60 to 64 years from the Medical Research Council National Survey of Health and Development. Combined heart rate and movement sensors worn for 5 consecutive days were used to derive overall PA energy expenditure, kJ/kg per day) and time spent sedentary (<1.5 metabolic equivalent of tasks), in light PA (1.5–3 metabolic equivalent of tasks) and moderate‐to‐vigorous intensity PA (>3 metabolic equivalent of tasks). Linear regression models were used to relate each PA parameter to inflammatory (C‐reactive protein, interleukin‐6), endothelial (tissue‐plasminogen activator, E‐selectin) and adipokine (leptin, adiponectin) markers extracted from fasting blood samples. Greater time in light PA and moderate‐to‐vigorous intensity PA and less sedentary time were associated with more favorable biomarker levels. For C‐reactive protein, interleukin‐6, and leptin, these differences were greater among women than men. For example, % differences (95% confidence intervals) in leptin for men and women per SD increases in sedentary time: 7.9 (2.7, 13.0) and 20.6 (15.3, 25.8); moderate‐to‐vigorous intensity PA: −3.8 (−8.9, 12.7) and −17.7 (−23.1, −12.4), moderate‐to‐vigorous intensity PA: −12.9 (−17.9, −8.0) and −18.3 (−23.4, −13.1). Fat mass mediated a greater proportion of these associations in women than men.ConclusionsGreater light PA and moderate‐to‐vigorous intensity PA and less sedentary time in early old age were associated with more favorable cardiovascular biomarker profiles. Fat mass partially mediated these associations but more strongly in women than men, which explained sex differences.

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“…A sedentary lifestyle is considered a health risk, and physical activity is an important modifiable factor contributing to risk reduction of cardiovascular diseases (CVD) and death [1–3]. Although the incidence of CVD in Norway has declined over the last decades [4], CVD is still a major cause of premature death and morbidity, and focus on preventive measures such as physical activity should continue [5–7].…”

Section: Introductionmentioning

confidence: 99%

The impact of changes in leisure time physical activity on changes in cardiovascular risk factors: results from The Finnmark 3 Study and SAMINOR 1, 1987–2003

Hermansen

Broderstad

Jacobsen

et al. 2018

International Journal of Circumpolar Health

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Objective: The aim of this study was to examine the associations between changes in leisure time physical activity and changes in cardiovascular risk factors over 16 years and whether they differ between two ethnic groups in Norway.Methods: Data were extracted from two population-based studies. Altogether, 3671 men and women participated in both surveys, and 30% reported being of Sami ethnicity. Leisure time physical activity was self-reported, and cardiovascular risk factors were measured. ANCOVA analysis was used to examine associations between changes in physical activity and changes in cardiovascular risk factors.Results: After adjustment for age, sex, smoking, ethnicity and respective baseline values, favourable changes in body mass index (BMI) and levels of triglycerides were most pronounced in those who were active in both surveys (p < 0.05) whereas the opposite was the situation for cholesterol levels (p = 0.003). Changes in systolic blood pressure, diastolic blood pressure and resting heart rate were not significantly associated with change in physical activity. Ethnicity did not influence the associations between physical activity and cardiovascular risk factors.Conclusion: Traditional cardiovascular risk factors were to a small extent associated with change in leisure time physical activity. Persistent physical activity was associated with beneficial changes in BMI and triglycerides.

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Physical activity and risk of cardiovascular disease

Abstract: This updated meta-analysis supports the notion of primary prevention of CVD through engagement in leisure time physical activity. The role of occupational physical activity in CVD prevention is questionable.

Cited by 176 publications

References 46 publications

Effects of leisure-time and occupational physical activities on 20-year incidence of acute myocardial infarction: mediation and interaction

Effects of leisure-time and occupational physical activities on 20-year incidence of acute myocardial infarction: mediation and interaction

Physical Activity, Sedentary Time, and Cardiovascular Disease Biomarkers at Age 60 to 64 Years

The impact of changes in leisure time physical activity on changes in cardiovascular risk factors: results from The Finnmark 3 Study and SAMINOR 1, 1987–2003

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