Effects of leisure-time and occupational physical activities on 20-year incidence of acute myocardial infarction: mediation and interaction

Abstract

High occupational physical activity (OPA) increased acute myocardial infarction (AMI) risk among workers with and without preexisting ischemic heart disease (IHD), however consistently only at low levels of leisure-time physical activity (LTPA). Workers with high OPA and low LTPA and workers with high LTPA and moderate OPA had the highest risks for AMI. LTPA did not mediate the impact of OPA on AMI risk. Affiliation:

Objectively Measured Sitting and Standing in Workers: Cross-Sectional Relationship with Autonomic Cardiac Modulation

“…However, we could not find a positive association between MVPA at work and sitting during leisure ( r = −0.1), which suggests that the trend for a decrease in HRV associated with more sitting during leisure time cannot be explained by increasing physical work demands. This is in line with a recent study by Wang et al 2016 that did not find any evidence for the mediation by leisure-time physical activity of an observed increased morality risk associated with occupational physical activity [53].…”

Physical activity and 22‐year all‐cause and coronary heart disease mortality

“…LTPA and some other variables could be considered both as confounders and as pathway variables, thus adjustment for them could constitute a partial over‐adjustment. However, in a recent mediation analysis based on this cohort data we demonstrated that OPA predicts LTPA but LTPA does not predict incidence of CHD among these working men and therefore the effect of OPA is not being mediated by LTPA . We also controlled for socioeconomic position by personal income.…”

Do highly physically active workers die early? A systematic review with meta-analysis of data from 193 696 participants

“…Moreover, some of these factors might actually be effect modifiers or pathway variables, for which interaction or mediation analyses would be more appropriate. These types of analyses have recently been performed with regard to leisure time PA71 and should be one focus of future occupational PA research.…”