Physical Activity and Postmenopausal Breast Cancer: Effect Modification by Breast Cancer Subtypes and Effective Periods in Life

Schmidt, Martina E.; Steindorf, Karen; Mutschelknauss, Elke; Slanger, Tracy; Kropp, Silke; Obi, Nadia; Flesch-Janys, Dieter; Chang‐Claude, Jenny

doi:10.1158/1055-9965.epi-08-0479

Cited by 82 publications

(89 citation statements)

References 36 publications

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“…These risk decreases were statistically significant in all studies except for one that found no effect modification by family history of breast cancer (Magnusson et al 2005). Hormone receptor status was examined in 11 studies as a potential effect modifier (Bardia et al 2006;Bernstein et al 2005;Dallal et al 2007;Dey et al 2009;Enger et al 2000;Lee et al 2001b;Leitzmann et al 2008;Maruti et al 2008;Peplonska et al 2008;Peters et al 2009a;Schmidt et al 2008). Seven studies examined the association between physical activity and breast cancer for estrogen positive (ER+) and negative (ER-) tumors (Bardia et al 2006;Bernstein et al 2005;Dallal et al 2007;Dey et al 2009;Peplonska et al 2008;Peters et al 2009a;Schmidt et al 2008).…”

Section: Population Subgroupsmentioning

confidence: 99%

“…An additional eight studies (11%) had a borderline, statistically significant breast cancer risk reduction (Hirose et al 2003;John et al 2003;Lee et al 2001b;Leitzmann et al 2008;Maruti et al 2008;McTiernan et al 1996;McTiernan et al 2003;Patel et al 2003), and 14 (19%) observed a statistically nonsignificant reduction (Adams-Campbell et al 2001;Chang et al 2006;Dey et al 2009;Dorn et al 2003;Dosemeci et al 1993;Friedenreich and Rohan 1995;Gilliland et al 2001;Hu et al 1997;Marcus et al 1999;Moradi et al 2002;Rintala et al 2003;Shin et al 2009;Slattery et al 2007;Sprague et al 2007). Nineteen (26%) studies produced null effects (Bardia et al 2006;Calle et al 1998;Chen et al 1997;Colditz et al 2003;Coogan and Aschengrau 1999;Gammon et al 1998;Gao et al 2009;Howard et al 2009;Lahmann et al 2007;Lee et al 2001a;Luoto et al 2000;Magnusson et al 2005;Mertens et al 2006;Nkondjock et al 2006;Schmidt et al 2008;Silvera et al 2006;Steindorf et al 2003;…”

Section: Overall Associations Between Physical Activity and Breast Camentioning

confidence: 99%

“…The second effect modifier, BMI, was examined in 22 studies (Breslow et al 2001;Colditz et al 2003;Dallal et al 2007;Friedenreich et al 2001;Gammon et al 1998;Hirose et al 2003;Kruk and Aboul-Enein 2003;Leitzmann et al 2008;Luoto et al 2000;Maruti et al 2008;McTiernan et al 2003;Moradi et al 2002;Patel et al 2003;Peplonska et al 2008;Peters et al 2009b;Schmidt et al 2008;Sesso et al 1998;Suzuki et al 2008;Tehard et al 2006;Thune et al 1997;Verloop et al 2000;Yang et al 2003). …”

Section: Population Subgroupsmentioning

confidence: 99%

“…The average risk reduction for white women was somewhat lower (20%) (Bardia et al 2006;Bernstein et al 2005;Chang et al 2006;Chen et al 1997;Coogan and Aschengrau 1999;Dallal et al 2007;Dirx et al 2001;Fraser and Shavlik 1997;Friedenreich et al 2001;Gilliland et al 2001;Hofvind and Thoresen 2001;Howard et al 2009;John et al 2003 Leitzmann et al 2008;Levi et al 1999;Luoto et al 2000;Magnusson et al 2005;Margolis et al 2005;Maruti et al 2008;Mezzetti et al 1998;Moradi et al 1999Moradi et al , 2000Moradi et al , 2002Peplonska et al 2008;Peters et al 2009a;Rintala et al 2002Rintala et al , 2003Schmidt et al 2008;Schnohr et al 2005;Slattery et al 2007; Steindorf et al 2003;Tehard et al 2006;Thune et al 1997;Verloop et al 2000). Nine studies included separate risk estimates for women with and without a family history of breast cancer (Bernstein et al 2005;Carpenter et al 2003;Dallal et al 2007;Hirose et al 2003;Magnusson et al 2005;…”

Section: Population Subgroupsmentioning

confidence: 99%

“…Hormone receptor status was examined in 11 studies as a potential effect modifier (Bardia et al 2006;Bernstein et al 2005;Dallal et al 2007;Dey et al 2009;Enger et al 2000;Lee et al 2001b;Leitzmann et al 2008;Maruti et al 2008;Peplonska et al 2008;Peters et al 2009a;Schmidt et al 2008). Seven studies examined the association between physical activity and breast cancer for estrogen positive (ER+) and negative (ER-) tumors (Bardia et al 2006;Bernstein et al 2005;Dallal et al 2007;Dey et al 2009;Peplonska et al 2008;Peters et al 2009a;Schmidt et al 2008). Five studies observed statistically significant breast cancer risk reductions for higher levels of physical activity among women with ER+ tumors (Bardia et al 2006;Bernstein et al 2005;Peplonska et al 2008;Peters et al 2009a;Schmidt et al 2008); two studies found significant reductions for ERtumors (Dallal et al 2007;Dey et al 2009).…”

Section: Population Subgroupsmentioning

confidence: 99%

See 4 more Smart Citations

Physical Activity and Genitourinary Cancer Survivorship

Galvão

Taaffe

Spry

et al. 2010

Physical Activity and Cancer

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Breast cancer is the most commonly diagnosed invasive malignancy and the second leading cause of cancer death in women. This chapter considers epidemiologic evidence re garding the association between physical activity and breast cancer risk from 73 studies conducted around the world. Across these studies there was a 25% average risk reduction amongst physically active women as compared to the least active women. The associations were strongest for recreational activity, for activity sustained over the lifetime or done after menopause, and for activity that is of moderate to vigorous intensity and performed regularly. There is also some evidence for a stronger effect of physical activity amongst postmenopausal women, women who are normal weight, have no family history of breast cancer, and are parous. It is likely that physical activity is associated with decreased breast cancer risk via multiple interrelated biologic pathways that may involve adiposity, sex hormones, insulin resistance, adipokines, and chronic inflammation. Future research should include prospective observational epidemiologic studies relating proposed biomarkers to breast cancer risk and also randomized controlled trials to examine how physical activity influences the proposed biomarkers. Exercise trials will provide more clarity regarding the appropriate type, dose, and timing of activity that relate to breast cancer risk reduction. IntroductionPhysical inactivity is one of the few established breast cancer risk factors amenable to intervention. Over 90 studies conducted worldwide have investigated some aspect of this association. In this chapter, we review the epidemiologic literature on physical activity and breast cancer risk, examining the effect of the different parameters of activity and effect modification within different population subgroups. We also review the biologic mechanisms whereby physical activity may influence the risk of breast cancer.

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Section: Population Subgroupsmentioning

confidence: 99%

Section: Overall Associations Between Physical Activity and Breast Camentioning

confidence: 99%

Section: Population Subgroupsmentioning

confidence: 99%

Section: Population Subgroupsmentioning

confidence: 99%

Section: Population Subgroupsmentioning

confidence: 99%

See 3 more Smart Citations

Physical Activity and Genitourinary Cancer Survivorship

Galvão

Taaffe

Spry

et al. 2010

Physical Activity and Cancer

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Reduced risk of breast cancer associated with recreational physical activity varies by HER2 status

Ursin

et al. 2015

Cancer Medicine

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Convincing epidemiologic evidence indicates that physical activity is inversely associated with breast cancer risk. Whether this association varies by the tumor protein expression status of the estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), or p53 is unclear. We evaluated the effects of recreational physical activity on risk of invasive breast cancer classified by the four biomarkers, fitting multivariable unconditional logistic regression models to data from 1195 case and 2012 control participants in the population-based Women’s Contraceptive and Reproductive Experiences Study. Self-reported recreational physical activity at different life periods was measured as average annual metabolic equivalents of energy expenditure [MET]-hours per week. Our biomarker-specific analyses showed that lifetime recreational physical activity was negatively associated with the risks of ER-positive (ER+) and of HER2-negative (HER2−) subtypes (both Ptrend ≤ 0.04), but not with other subtypes (all Ptrend > 0.10). Analyses using combinations of biomarkers indicated that risk of invasive breast cancer varied only by HER2 status. Risk of HER2–breast cancer decreased with increasing number of MET-hours of recreational physical activity in each specific life period examined, although some trend tests were only marginally statistically significant (all Ptrend ≤ 0.06). The test for homogeneity of trends (HER2– vs. HER2+ ) reached statistical significance only when evaluating physical activity during the first 10 years after menarche (Phomogeneity = 0.03). Our data suggest that physical activity reduces risk of invasive breast cancers that lack HER2 overexpression, increasing our understanding of the biological mechanisms by which physical activity acts.

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Trends in the incidence of cancer in the Sousse region, Tunisia, 1993–2006

Missaoui¹,

Trabelsi

Parkin

et al. 2010

Intl Journal of Cancer

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In this article, we analyzed trends in incidence rates of the major cancer sites for a 14-year period, 1993-2006, in the Sousse region localized in the centre of Tunisia. Five-year age-specific rates, crude incidence rates (CR), world age-standardized rates (ASR), percent change (PC) and annual percent change (APC) were calculated using annual data on population size and its estimated age structure. A total of 6,975 incident cases of cancer were registered, with a male to-female sex ratio of 1.4:1. ASRs showed stable trends (20.1% in males, and 11.0% in females). The leading cancer sites in rank were lung, breast, lymphoma, colon-rectum, bladder, prostate, leukemia, stomach and cervix uteri. For males, the incidence rates of lung, bladder and prostate cancers remained stable over time. While, cancers of colon-rectum showed a marked increase in incidence (APC: 14.8%; 95% CI: 1.2%, 8.4%) and non-Hodgkin's lymphoma (NHL) showed a notable decline (APC: 24.4%; 95% CI: 28.2, 20.6). For females, cancers of the breast (APC: 12.2%; 95% CI: 0.4%, 4.0%) and corpus uteri (APC: 17.4%; 95% CI: 2.8%, 12.0%) showed a marked increase in incidence during the study period, while the cervix uteri cancer decreased significantly (APC: 26.1%; 95% CI: 29.2%, 23.0%). The results underline the increasing importance of cancer as a cause of mortality and morbidity in Tunisia. Our findings justify the need to develop effective program aiming at the control and prevention of the spread of cancer amongst Tunisian population.Cancer is an eminent health problem in the developing countries. The high-ranking cancer instances that have been reported are, primarily, the outcome of growing population rates, increasing tobacco consumption, industrialization and westernization of diet and lifestyle.1,2 The establishment of population-based cancer registries provides more accurate statistics and help to improve both the monitoring of cancer trends over time and the understanding of this growing epidemic. [3][4][5] In Tunisia, there are almost three population-based cancer registries at the present time providing data on cancer incidence and survival. 5 The population-based cancer registry of the centre of Tunisia was established in 1987 under the auspices of the International agency of research on cancer (IARC), Lyon, France and located in the Pathology Department of the Farhet Hached University Hospital, Sousse, Tunisia. The cancer registry has provided important information on cancer patterns over the previous years. The quality of the data provided by the cancer registry of the centre region of Tunisia was judged quite appropriate to appear in ''Cancer Incidence in Five Continents (CI5) Vol. IX'' 6 and ''Cancer in Africa, Epidemiology and Prevention. '' 5 In this article, we report trends in the cancer incidence during the span of time between 1993 and 2006 from the population-based cancer registry of the centre of Tunisia. Material and Methods Data collection and follow-upCancer registry of the centre region of Tunisia includes six provinces: ...

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Physical Activity and Postmenopausal Breast Cancer: Effect Modification by Breast Cancer Subtypes and Effective Periods in Life

Cited by 82 publications

References 36 publications

Physical Activity and Genitourinary Cancer Survivorship

Physical Activity and Genitourinary Cancer Survivorship

Reduced risk of breast cancer associated with recreational physical activity varies by HER2 status

Trends in the incidence of cancer in the Sousse region, Tunisia, 1993–2006

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