Reduced risk of breast cancer associated with recreational physical activity varies by <scp>HER</scp>2 status

Ma, Hui; Xu, Xinxin; Ursin, Giske; Simon, Michael S.; Marchbanks, Polly A.; Malone, Kathleen E.; Lu, Yani; McDonald, Jill A.; Folger, Suzanne G.; Weiss, Linda K.; Sullivan‐Halley, Jane; Deapen, Dennis; Press, Michael F.; Bernstein, Leslie

doi:10.1002/cam4.465

Cited by 18 publications

(14 citation statements)

References 59 publications

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“…The presence of chemicals generated by smoking has been detected in mammary gland tissue of both healthy women and breast cancer patients (50)(51)(52). In vitro studies suggest that nicotine (31), benzo(a) pyrene (53), 1-methylanthracene (54), and penanthrene (55) may provoke alterations in epigenetic and transcriptional mechanisms which regulates the expression of genes that are involved in transformation of healthy epithelial cells, proliferation, and metastasis of tumor epithelial cells into the mammary gland (26). There are carcinogens in tobacco smoke such as polycyclic aromatic hydrocarbons (PAH), aromatic amines, and nitrosoamines (20), and these carcinogens can have both estrogenic (56) and antiestrogenic effects (57,58).…”

Section: Smokingmentioning

confidence: 99%

“…The association between physical activity and breast cancer subtypes have been investigated in several studies (26)(27)(28)(29)(30)(31)(32)(35)(36)(37). Some of these studies had information on ER only, ER and PR (27,(30)(31)(32)37), and others had information on ER, PR, and HER2 (26,28,29,35,36). Of all these studies, two of them had fewer than 700 cases (29,35) and six studies included from 1,921 to 5,882 cases (26-28, 31, 32, 36).…”

Section: Physical Activitymentioning

confidence: 99%

“…Alcohol consumption, physical activity, and smoking are modifiable risk factors that have been associated with breast cancer overall to some or larger degree (4)(5)(6). Several studies have investigated the association between alcohol (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18), smoking (14,(19)(20)(21)(22)(23)(24)(25), physical activity (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36), and subtypes of breast cancer. A large meta-analysis suggested stronger positive associations between alcohol and estrogen receptor (ER)-positive tumors and weaker positive associations between alcohol and ER-negative tumors (18).…”

Section: Introductionmentioning

confidence: 99%

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Alcohol, Physical Activity, Smoking, and Breast Cancer Subtypes in a Large, Nested Case–Control Study from the Norwegian Breast Cancer Screening Program

Ellingjord-Dale

Vos

Hjerkind

et al. 2017

Cancer Epidemiology, Biomarkers &Amp; Prevention

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To what extent alcohol, smoking, and physical activity are associated with the various subtypes of breast cancer is not clear. We took advantage of a large population-based screening cohort to determine whether these risk factors also increase the risk of the poor prognosis subtypes. We conducted a matched case-control study nested within the Norwegian Breast Cancer Screening Program during 2006-2014. A total of 4,402 breast cancer cases with risk factor and receptor data were identified. Five controls were matched to each case on year of birth and year of screening. Conditional logistic regression was used to estimate ORs of breast cancer subtypes adjusted for potential confounders. There were 2,761 luminal A-like, 709 luminal B-like HER2-negative, 367 luminal B-like HER2-positive, 204 HER2-positive, and 361 triple-negative cancers. Current alcohol consumption was associated with breast cancer risk overall [OR 1.26; 95% confidence interval (CI), 1.09-1.45] comparing 6+ glasses a week to never drinkers. However, this risk increase was found only for luminal A-like breast cancer. Smoking 20+ cigarettes a day was associated with an OR of 1.41 (95% CI, 1.06-1.89) overall, with significant trends for luminal A-like and luminal B-like HER2-negative cancer. Current physical activity (4+ hours/week compared with none) was associated with 15% decreased risk of luminal A-like cancer, but not clearly with other subtypes. In this large study, alcohol, smoking, and physical activity were predominantly associated with luminal A-like breast cancer. Alcohol, smoking, and physical activity were associated with luminal A-like breast cancer subtype. .

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Section: Smokingmentioning

confidence: 99%

Section: Physical Activitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Alcohol, Physical Activity, Smoking, and Breast Cancer Subtypes in a Large, Nested Case–Control Study from the Norwegian Breast Cancer Screening Program

Ellingjord-Dale

Vos

Hjerkind

et al. 2017

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Five studies reported statistically significant association only among women with ER+ or ER+/PR+ breast cancer [43][44][45][46][47], whereas three studies found risk reduction limited to women with ER-or ER-/PR-breast cancer [3,48,50]. Only three studies to date have investigated the association between recreational physical activity and TNBC [4][5][6]. The Women's Health Initiative Cohort Study reported that risks of both TNBC and ER+ breast cancer were inversely associated with recreational physical activity among postmenopausal women [4].…”

Section: Discussionmentioning

confidence: 99%

“…We were unable to evaluate risk of triple negative breast cancer (TNBC, ER-/PR-/HER2-) in the earlier publication because HER2 data were not available for cases diagnosed before 1999. To our knowledge, only the Women's Health Initiative Cohort Study [4] and two case-control studies [5,6] have investigated the association between recreational physical activity and TNBC risk.…”

Section: Introductionmentioning

confidence: 99%

Abstract 872: Long-term and recent recreational physical activity reduces risk of triple negative and other subtypes of invasive breast cancer in the California Teachers Study

Clague

et al. 2015

Cancer Research

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Background: Evidence has accumulated showing that recreational physical activity reduces breast cancer risk. However, it is unclear whether risk reduction pertains to specific receptor-defined subtypes. Moreover, few studies have examined whether changes in the amount of recreational physical activity during adulthood influence breast cancer risk. Methods: A total of 108,907 women, ages 22 to 79 years with no history of breast cancer when joining the California Teachers Study in 1995-1996, completed a baseline questionnaire and were eligible for the study. Through 2012, 5882 women were diagnosed with invasive breast cancer. Breast cancer subtypes were defined by the expression status of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Multivariable Cox proportional hazards models provided adjusted hazard ratios (HRs) and 95 % confidence intervals (CIs) for breast cancer overall and ER/PR/HER2-defined subtypes associated with long-term (from high school through age 54 or age at cohort entry, whichever was younger) and baseline (during 3 years prior to baseline) recreational physical activity. Among women who also completed a follow-up questionnaire at 10 years after baseline in 2005-2008 (54,686 women, 1406 with invasive breast cancer), risk associated with changes in the amount of recreational physical activity from baseline to the 10-year follow-up (during 3 years prior to the 10-year follow-up) was determined. Results: Both long-term and baseline strenuous recreational physical activity were inversely associated with risk of invasive breast cancer (P trend ≤0.03). The observed associations were mainly confined to women with triple negative breast cancer (TNBC, ER-/PR-/HER2-, P trend ≤0.02) or luminal Alike subtype (ER+ or PR+ plus HER2-) who were former users of menopausal hormone therapy at baseline (P trend = 0.02, P homogeneity of trends ≤0.03). Moreover, women who consistently engaged in the highest level (≥3.51 h/wk/y) of strenuous recreational physical activity between baseline and 10-year follow-up had the lowest risk of breast cancer (HR = 0.71, 95 % CI = 0.52-0.98) when compared to those who were consistently low (≤0.50 h/wk/y). Conclusions: Strenuous recreational physical activity is associated with lower breast cancer risk, especially TNBC. The benefit may be maximized by consistently engaging in high-intensity recreational physical activity during adulthood.

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Quantitative diagnosis of HER2 protein expressing breast cancer by single‐particle quantum dot imaging

et al. 2016

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Overexpression of HER2 is one of the major causes of breast cancer, and therefore precise diagnosis of its protein expression level is important. However, current methods estimating the HER2‐expression level are insufficient due to problem with the lack of quantification. This might result in a gap between diagnostics and therapeutics targeting HER2. Therefore, a new effective diagnostic method is needed. We developed a new immunohistochemical (IHC) technique with quantum dots (QD)‐conjugated trastuzumab using single‐particle imaging to quantitatively measure the HER2 expression level. Tissues from 37 breast cancer patients with available detailed clinical information were tested by IHC with QDs (IHC‐QD) and the correlation with IHC with 3,3′‐diaminobenzidine (DAB), fluorescence in situ hybridization (FISH), and IHC‐QD was examined. The number of QD‐conjugated trastuzumab particles binding specifically to a cancer cell was precisely calculated as the IHC‐QD score. The IHC‐QD score in 37 cases was correlated proportionally with the score of HER2 gene copy number as assessed by FISH (R = 0.83). When HER2 positivity was judged to be positive, the IHC‐QD score with our cut‐off level was exactly concordant with the FISH score with a cut‐off value of 2.0. Furthermore, IHC‐QDs score and time to progression (TTP) of trastuzumab therapy were well correlated in HER2‐positive cases (R = 0.69). Conversely, the correlation between FISH score and TTP was not observed. We developed a precisely quantitative IHC method using trastuzumab‐conjugated QDs and single‐particle imaging analysis and propose the possibility of using IHC‐QDs score as a predictive factor for trastuzumab therapy.

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Reduced risk of breast cancer associated with recreational physical activity varies by HER2 status

Cited by 18 publications

References 59 publications

Alcohol, Physical Activity, Smoking, and Breast Cancer Subtypes in a Large, Nested Case–Control Study from the Norwegian Breast Cancer Screening Program

Alcohol, Physical Activity, Smoking, and Breast Cancer Subtypes in a Large, Nested Case–Control Study from the Norwegian Breast Cancer Screening Program

Abstract 872: Long-term and recent recreational physical activity reduces risk of triple negative and other subtypes of invasive breast cancer in the California Teachers Study

Quantitative diagnosis of HER2 protein expressing breast cancer by single‐particle quantum dot imaging

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