Physical activity and laryngeal cancer

Abstract

Although an active lifestyle physical has been convincingly associated with a decreased risk of developing many forms of cancers, including neck and head malignancies, uncertainty surrounds the relationship between physical activity (PA) and laryngeal carcinogenesis. Epidemiologic evidence, garnered from some well-conducted cross-sectional, prospective and retrospective studies, seemingly attests that the impact of PA may be not so straightforward in lowering laryngeal cancer risk as for other malignancies.Reasonable consensus has been reached that moderate-intensity PA may generate the larger potential benefits, whilst the effect of high-intensity PA appears more controversial and even contradictory. This is mainly attributable to the fact that moderate PA may have more favorable effects than high-intensity exercise in decreasing the impact of some risk factors of laryngeal cancer such as metabolic syndrome, cigarette smoking, inflammation, and gastroesophageal reflux disease. Significant biological and psychological benefits from moderate-intensity exercise have also been described in patients surviving from primary laryngeal cancers.This would hence lead us to conclude that promotion of an active lifestyle, characterized by performance of moderate-intensity PA (e.g., between 3 and 6 metabolic equivalents, equaling short distance running), may be beneficial for lowering the risk of developing laryngeal cancer and for improving the quality of life of larynx cancer survivors.

The Effect of Metabolic Syndrome on Head and Neck Cancer Incidence Risk: A Population-based Prospective Cohort Study

“…Overweight/obesity is strongly correlated with glucose intolerance and type II diabetes 37, 38 ; however, our study observed that central obesity was not an independent risk factor for HNC. Further analysis suggested that waist circumference was signi cantly correlated with HNC risk in a U-shape manner and higher female waist circumference increased risk when it was more than 93.16 cm, which was consistent with the previous study that suggested moderate-intensity physical activity (equal to short-distance running) may be bene cial for reducing laryngeal cancer risk 39 . Interestingly, some studies have showed that high level of HDL is protective against cancer; however, we found that high HDL level also increase the risk of HNC in men.…”

High‐intensity exercise to improve cardiorespiratory fitness in cancer patients and survivors: A systematic review and meta‐analysis

“…27 The consensus of exercise to cancer patients suggests; moderate-to-high intensity aerobic exercise, resistance exercise or a combination of both conduct on a frequency of 2-3 sessions per week for between 8 and 12 weeks. 27 While most cancer-related exercise interventions have been limited to low-intensity 28 and/ or moderate-intensity exercise, 29 evidence is emerging from randomized controlled trials (RTC) to suggest that health outcomes are as good if not better from higher intensity exercise protocols in adult cancer survivors. 30,31 High-intensity training (HIT) can induce greater improvements in CRFit than moderate continuous aerobic exercise in patients with heart failure 32 or stroke.…”

A dynamic prognostic nomogram to predict the benefit from surgical treatment modality for patients with laryngeal squamous cell carcinoma

“…Laryngeal cancer is a common malignant neoplasm that arises from the larynx, of which the main histological type (approximating 98%) is laryngeal squamous cell carcinoma (LSCC). 1,2 In the United States, it accounts for about 25% of all head and neck cancers, with an estimated 15 000 new cases diagnosed every year. 3,4 The known predisposing factors related to laryngeal cancer include tobacco and alcohol consumption.…”