Physical Activity and Breast Cancer

Monninkhof, Evelyn M.; Elias, Sjoerd G.; Vlems, F. A.; Tweel, Ingeborg van der; Schuit, Albertine J.; Voskuil, D.W.; Leeuwen, Flora E. van

doi:10.1097/01.ede.0000251167.75581.98

Cited by 442 publications

(347 citation statements)

References 62 publications

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“…The literature on physical activity and breast cancer risk in the general population [9] indicates a risk reduction of 25-30%, independent of BMI, with a dose-response effect (for each additional hour of activity per week the risk decreased by 6%). Stronger decreases in risk were reported for, among others, recreational activity, lifetime or later life activity, vigorous activity, among postmenopausal women, women with normal BMI, and those with hormone receptor-negative tumors [13].…”

Section: Discussionmentioning

confidence: 99%

“…In the general population, proposed mechanisms for a protective effect from physical activity are decreased lifetime exposure to estrogens and decreased percent of visceral body fat [34][35][36]. Furthermore, in the general population, the association between physical activity and breast cancer risk is most pronounced for postmenopausal and weaker for premenopausal breast cancer [9]. However, the evidence that physical activity may protect against premenopausal breast cancer is increasing [14][15][16].…”

Section: Discussionmentioning

confidence: 99%

“…Differences in penetrance between generations, together with differences in age at onset and phenotypic expression between and within BRCA1/2 families, indicate that the risk of breast cancer may also be influenced by modifying genes and by environmental and lifestyle factors (with changing prevalence over time) [8]. It is well established that increased levels of physical activity decrease the risk of breast cancer in the general population by approximately 20-40% [9][10][11][12][13]. The association is most pronounced for postmenopausal women, although several recent large prospective cohort studies concluded that increased physical activity may decrease the risk for premenopausal breast cancer as well [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Physical activity and the risk of breast cancer in BRCA1/2 mutation carriers

Pijpe

Manders

Brohet

et al. 2009

Breast Cancer Res Treat

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BRCA1/2 mutation carriers have a high lifetime risk of developing breast cancer. Differences in penetrance indicate that this risk may be influenced by lifestyle factors. Because physical activity is one of the few modifiable risk factors, it may provide a target to add to breast cancer prevention in this high-risk population. We examined the association between self-reported lifetime sports activity and breast cancer risk in a nationwide retrospective cohort study, including 725 carriers, of whom 218 had been diagnosed with breast cancer within 10 years prior to questionnaire completion. We found a nonsignificantly decreased risk for ever engaging in sports activity (HR = 0.84, 95%CI = 0.57-1.24). Among women who had participated in sports, a medium versus low level of intensity and duration (i.e., between 11.0 and 22.7 mean MET hours/week averaged over a lifetime) reduced the risk of breast cancer (HR = 0.59, 95%CI = 0.36-0.95); no dose-response trend was observed. For mean hours/week of sports activity, a nonsignificant trend was observed (HR low versus never = 0.93, 95%CI = 0.60-1.43; HR medium versus never = 0.81, 95%CI = 0.51-1.29; HR high versus never = 0.78, 95%CI = 0.48-1.29; p trend overall = 0.272; p trend active women = 0.487). For number of years of sports activity no significant associations were found. Among women active in sports before age 30, mean MET hours/week showed the strongest inverse association of all activity measures (HR medium versus low = 0.60, 95%CI = 0.38-0.96; HR high versus low = 0.58, 95%CI = 0.35-0.94; p trend = 0.053). Engaging in sports activity after age 30 was also inversely associated with breast cancer risk (HR = 0.63, 95%CI = 0.44-0.91). Our results indicate that sports activity may reduce the risk of breast cancer in BRCA1/2 mutation carriers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Physical activity and the risk of breast cancer in BRCA1/2 mutation carriers

Pijpe

Manders

Brohet

et al. 2009

Breast Cancer Res Treat

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“…2 Also, a multitude of studies have demonstrated the positive effects of physical activity in reducing the risk of developing breast cancer. 3 It has been suggested that so-called modifiable components such as obesity and insulin resistance, which are influenced by physical activity, may also affect cancer survival. 4,5 We have previously reported in a systematic review that physical activity is associated with overall survival and breast cancer-specific survival, with postdiagnosis physical activity being most beneficial for these breast cancer outcomes.…”

Section: Introductionmentioning

confidence: 99%

Physical activity and survival of postmenopausal, hormone receptor–positive breast cancer patients: Results of the Tamoxifen Exemestane Adjuvant Multicenter Lifestyle study

Glas

Fontein

Bastiaannet

et al. 2014

Cancer

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BACKGROUND: Physical activity has been related to improved breast cancer outcomes. Especially in the older breast cancer population, physical activity may be important because old age is associated with comorbidities and decreased physical function. The purpose of this study was to investigate the relation between physical activity and overall survival, breast cancer-specific survival, and recurrence in several age groups of postmenopausal breast cancer patients. METHODS: The Tamoxifen Exemestane Adjuvant Multinational Lifestyle study was a side study of the Tamoxifen Exemestane Adjuvant Multinational trial and prospectively investigated lifestyle habits of postmenopausal, hormone receptor-positive breast cancer patients. The relations between prediagnosis and postdiagnosis physical activity and overall survival, breast cancer-specific survival, and recurrence-free survival were assessed with Cox regression and competing risk regression models. RESULTS: Among 521 patients, high levels of physical activity before and after the diagnosis were associated with better overall survival (the multivariate hazard ratios were 0.50 [95% confidence interval 5 0.26-0.98] and 0.57 (95% confidence interval 5 0.26-1.40] for patients who were very active before and after the diagnosis, respectively, in comparison with inactive patients). This was most evident in patients who were 65 years old or older. Physical activity was not significantly associated with breast cancer-specific survival or the relapse-free period. CONCLUSIONS: Overall survival was better for patients who were active before and after the diagnosis. In contrast with previous studies, breast cancer survival and the risk of recurrence were not significantly associated with physical activity. These findings confirmed the need for more studies investigating the use of physical activity to supplement breast cancer treatment in older patients. Cancer 2014;120:2847-54.

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“…The idea to modify at least three of these factors, i.e. alimentation, diet habits, physical activity, struggle of obesity makes it possible to reduce the incidence of breast cancer (Monninkhof et al, 2007;Cummings et al, 2009;Khan et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Assessment of Midwifery Student Preparation for Performing the Role of Breast Cancer Educator

Bień¹,

Korżyńska-Piętas²,

Iwanowicz-Palus³

2014

Asian Pacific Journal of Cancer Prevention

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Relations between opposing characteristics were tested with Chi-square (x 2 ) test for independent traits. To assess the dependence relation between the examined variables Pearson's corrected coefficient was used. Data base and statistics were carried out with computer software STATISTICA 9.0 (StatSoftPoland). Conclusions: Student knowledge on prevention against breast cancer was unsatisfactory.The students place of residence determined their self-estimation of personal knowledge of breast cancer prevention and diagnosing methods to assess the incidence of the disease, this knowledge being better with the students of Lublin. Better self-estimation in the students of Lublin of their personal knowledge on factors rising the risk of breast cancer, such as alimentation method, application of oral contraceptives and breast feeding was found than in Belgian students.

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Physical Activity and Breast Cancer

Abstract: There is evidence for an inverse association between physical activity and breast cancer risk. The evidence is stronger for postmenopausal breast cancer than for premenopausal breast cancer.

Cited by 442 publications

References 62 publications

Physical activity and the risk of breast cancer in BRCA1/2 mutation carriers

Physical activity and the risk of breast cancer in BRCA1/2 mutation carriers

Physical activity and survival of postmenopausal, hormone receptor–positive breast cancer patients: Results of the Tamoxifen Exemestane Adjuvant Multicenter Lifestyle study

Assessment of Midwifery Student Preparation for Performing the Role of Breast Cancer Educator

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