Physcion, a novel inhibitor of 5α-reductase that promotes hair growth in vitro and in vivo

Lao, Zizhao; Fan, Yaohua; Huo, Yuhang; Liao, Feng; Zhang, Rongwen; Zhang, Bei; Kong, Ziyun; Long, Haishan; Xie, Jieliang; Sang, Chuanlan; Fu, Lu‐Di; Lin, Ji; Yu, Liang; Li, Geng

doi:10.1007/s00403-021-02195-1

Cited by 12 publications

(12 citation statements)

References 31 publications

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“…From the 8th day after topical administration, hair regrowth was scored every other day to be able to dynamically observe the rate of hair growth. We scored hair growth according to the percentage of hair growth in the depilated area: 0 to 20% was scored as 1, 20% to 40% as 2, 40% to 60% as 3, 60% to 80% as 4 and 80% to 100% as 5 [16]. After 28 days of treatment, the mice were euthanized by carbon dioxide asphyxiation, and the skin of the dorsal experimental area was obtained for further experiments.…”

Section: Animal Experimentsmentioning

confidence: 99%

Caizhixuan hair tonic regulates both apoptosis and the PI3K/Akt pathway to treat androgenetic alopecia

Fang

<²,

Sun

et al. 2023

PLoS ONE

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Purpose Caizhixuan hair tonic (CZX) is a topical traditional Chinese medicine (TCM) preparation for the treatment of androgenetic alopecia (AGA). However, its active compounds and underlying mechanism for treating AGA are still unclear. The purpose of this study was to observe the effects of CZX on hair growth promotion in AGA mice and to explore the active components and mechanism. Methods Testosterone propionate was administered subcutaneously to mice to establish an AGA mouse model. The therapeutic effects of CZX on AGA were evaluated by observing skin colour changes, hair growth time, and average hair length; calculating the hair growth score; and performing skin histopathological analysis. Following that, CZX chemical components were analysed by ultra-high-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry (UPLC–Q–TOF/MS). Network pharmacology was used to predict the major effects and possible mechanisms of CZX for the treatment of AGA. Furthermore, RT-qPCR and Western blotting were performed to assess the expression of key genes and proteins involved in PI3K/Akt and apoptosis pathways in order to validate CZX’s predicted mechanism in AGA. Results CZX promoted hair growth and improved the pathological morphology of hair follicles in the skin. In UPLC–Q–TOF/MS analysis, 69 components from CZX were isolated. Based on network pharmacology, CZX alleviated AGA by regulating PI3K/Akt and apoptosis pathways. According to RT-qPCR and Western blotting, CZX upregulated the expressions of PI3K, Akt, and Bcl-2, while downregulating that of Bax and caspase-3. Conclusions CZX promotes hair growth to treat AGA by regulating the PI3K/Akt and apoptosis pathways.

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Section: Animal Experimentsmentioning

confidence: 99%

Caizhixuan hair tonic regulates both apoptosis and the PI3K/Akt pathway to treat androgenetic alopecia

Fang

<²,

Sun

et al. 2023

PLoS ONE

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“…It is also a useful compound able to promote hair growth through the inhibition of 5α-reductase (IC 50 = 191.9 μM). It is therefore of potential interest for treating androgenic alopecia [ 36 ].…”

Section: Phytochemical Content Of Fissistigma Oldhamiimentioning

confidence: 99%

Fissistigma oldhamii (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological Aspects

Bailly

2023

Plants

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The species Fissistigma oldhamii (Hemsl.) Merr. (Annonaceae) has long been used as a traditional herbal medicine in China to treat diverse human diseases. Decoctions from the roots of the plant (Guā Fù Mù) are used to treat body pain and inflammatory pathologies, such as rheumatic syndromes, sciatica, and osteoarthritis. The phytochemical content of the plant and the associated pharmacological activities have been analyzed. Seventy natural products were identified in the different parts of the plants, namely, the roots, stems, leaves, fruits, and seeds. The compounds comprise many tri- and tetracyclic alkaloids (aporphine-type), anthraquinones, terpenoids, flavonoids, and others. The pharmacological properties of these molecules were analyzed to point out the anti-inflammatory, antioxidant, anticancer, and/or antimicrobial effects, together with the underlying modulated pathways and molecular targets in some cases. The panel of phytoconstituents present in F. oldhamii extracts is large, with the majority of bioactive products identified in the roots and stems. Multiple molecules can contribute to the anti-inflammatory properties of the extracts. Network pharmacology analyses of the phytoconstituents are needed to better delineate the effective components and their targets.

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“…Physcion, a component of Polygonum multiforum (PM), has anti-inflammatory, antioxidant, and anticancer effects [192,193]. Treatment with physcion exhibited hair growth-promoting activity in testosterone-treated C57BL/6 mice [51]. In addition, physcion inhibits 5α-reductase expression in vivo [51].…”

Section: α-Reductase Inhibitory Effectmentioning

confidence: 99%

“…Treatment with physcion exhibited hair growth-promoting activity in testosterone-treated C57BL/6 mice [51]. In addition, physcion inhibits 5α-reductase expression in vivo [51]. Rosmarinus officinalis belongs to the Lamiaceae family and has been widely studied for its antibacterial, antioxidant, and anticancer activities [194][195][196].…”

Section: α-Reductase Inhibitory Effectmentioning

confidence: 99%

Modulation of Hair Growth Promoting Effect by Natural Products

Park

Lee

2021

Pharmaceutics

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A large number of people suffer from alopecia or hair loss worldwide. Drug-based therapies using minoxidil and finasteride for the treatment of alopecia are available, but they have shown various side effects in patients. Thus, the use of new therapeutic approaches using bioactive products to reduce the risk of anti-hair-loss medications has been emphasized. Natural products have been used since ancient times and have been proven safe, with few side effects. Several studies have demonstrated the use of plants and their extracts to promote hair growth. Moreover, commercial products based on these natural ingredients have been developed for the treatment of alopecia. Several clinical, animal, and cell-based studies have been conducted to determine the anti-alopecia effects of plant-derived biochemicals. This review is a collective study of phytochemicals with anti-alopecia effects, focusing mainly on the mechanisms underlying their hair-growth-promoting effects.

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Physcion, a novel inhibitor of 5α-reductase that promotes hair growth in vitro and in vivo

Cited by 12 publications

References 31 publications

Caizhixuan hair tonic regulates both apoptosis and the PI3K/Akt pathway to treat androgenetic alopecia

Caizhixuan hair tonic regulates both apoptosis and the PI3K/Akt pathway to treat androgenetic alopecia

Fissistigma oldhamii (Hemsl.) Merr.: Ethnomedicinal, Phytochemistry, and Pharmacological Aspects

Modulation of Hair Growth Promoting Effect by Natural Products

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