Phylogeny of Isodon (Schrad. ex Benth.) Spach (Lamiaceae) and Related Genera Inferred from Nuclear Ribosomal ITS, trnL–trnF Region, and rps16 Intron Sequences and Morphology

Zhong, Jinshun; Li, Jie; Li, Lang; Conran, John G.; Li, Hsi-Wen

doi:10.1600/036364410790862614

Cited by 44 publications

(43 citation statements)

References 39 publications

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“…In addition to 18 samples newly sequenced for this paper, 40 samples were included from a previous study [27] to provide phylogenetic context and to help with the analysis of patterns of oridonin evolution. Coleus xanthanthus C. Y. Wu & Y. C. Huang was used as the outgroup, using Genbank sequences from another study [27]. A list of all sequences and associated Genbank identification numbers is provided in Table S1.…”

Section: Methodsmentioning

confidence: 99%

“…The center of diversity of the genus is in China, where 77 species of the genus are located [26]. Although the classification of Isodon has been well studied, recent molecular phylogenetic work has placed the traditional subgeneric classification in question [27]. In addition, a study of Isodon in Japan using chloroplast sequence markers found low phylogenetic resolution and many species were polyphyletic.…”

Section: Introductionmentioning

confidence: 99%

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Selection for High Oridonin Yield in the Chinese Medicinal Plant Isodon (Lamiaceae) Using a Combined Phylogenetics and Population Genetics Approach

et al. 2012

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Oridonin is a diterpenoid with anti-cancer activity that occurs in the Chinese medicinal plant Isodon rubescens and some related species. While the bioactivity of oridonin has been well studied, the extent of natural variation in the production of this compound is poorly known. This study characterizes natural variation in oridonin production in order to guide selection of populations of Isodon with highest oridonin yield. Different populations of I. rubescens and related species were collected in China, and their offspring were grown in a greenhouse. Samples were examined for oridonin content, genotyped using 11 microsatellites, and representatives were sequenced for three phylogenetic markers (ITS, rps16, trnL-trnF). Oridonin production was mapped on a molecular phylogeny of the genus Isodon using samples from each population as well as previously published Genbank sequences. Oridonin has been reported in 12 out of 74 species of Isodon examined for diterpenoids, and the phylogeny indicates that oridonin production has arisen at least three times in the genus. Oridonin production was surprisingly consistent between wild-collected parents and greenhouse-grown offspring, despite evidence of gene flow between oridonin-producing and non-producing populations of Isodon. Additionally, microsatellite genetic distance between individuals was significantly correlated with chemical distance in both parents and offspring. Neither heritability nor correlation with genetic distance were significant when the comparison was restricted to only populations of I. rubescens, but this result should be corroborated using additional samples. Based on these results, future screening of Isodon populations for oridonin yield should initially prioritize a broad survey of all species known to produce oridonin, rather than focusing on multiple populations of one species, such as I. rubescens. Of the samples examined here, I. rubescens or I. japonicus from Henan province would provide the best source of oridonin.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Selection for High Oridonin Yield in the Chinese Medicinal Plant Isodon (Lamiaceae) Using a Combined Phylogenetics and Population Genetics Approach

et al. 2012

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“…However, because the monophyly of all series in sect. Isodon was unresolved (Maki et al 2010;Zhong et al 2010), here we can only conclude that I. wui is morphologically most similar to I. irroratus, due to their shared similarities in general floral and calyx morphology.…”

Section: Isodon Wuimentioning

confidence: 65%

“…Section Isodon contains around two-thirds of the species and was further subdivided into ten series. However, molecular phylogenetic studies (Maki et al 2010;Zhong et al 2010) neither reflect previous taxonomic treatments at the section and series levels (Wu and Li 1977;Li 1988) nor support the monophyly of Isodon. Rather, the genus can only be considered monophyletic when the monotypic genus Skapanthus C. Y. Wu & H. W. Li is included in Isodon (Zhong et al 2010).…”

mentioning

confidence: 87%

“…As currently circumscribed, the genus comprises roughly 100 species that occur in two disjunct areas: tropical Africa (two species), and subtropical to temperate East Asia (Codd 1968(Codd ,1984Li 1988;Mabberley 2008). In China, 77 species and 10 varieties have been reported, of which 63 species and six varieties are endemic and geographically restricted and southwest China is considered to be the diversity center of the genus (Zhong et al 2010). Li (1988) divided the genus into four sections: sect.…”

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confidence: 99%

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A New Species of Isodon (Lamiaceae, Nepetoideae) from Yunnan Province, Southwest China

Xiang¹,

Liu²

2012

issn: 0363-6445

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Isodon iviii (Lamiaceae), from Mt. Jiaozi in Yunnan province, is newly described and illustrated. The new species is morphologically most similar to /. irroratus but is smaller and has narrowly ovate (vs. ovate) leaves and leaf surfaces with unicellular, eglandular (vs. clávate, glandular) trichomes. The new species differs from /. irroratus in geographical distribution by occurring in central Yunnan instead of northwestern Yunnan and Sichuan. Features of the new species pertaining to leaf surface anatomy, pollen morphology, and geographical distribution are described, and a key to all 42 species of isodon in Yunnan province is provided.

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Phylogeny of the subtribe Hyptidinae (Lamiaceae tribe Ocimeae) as inferred from nuclear and plastid DNA

Pastore

Harley

Forest

et al. 2011

TAXON

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Phylogenetic analyses of the subtribe Hyptidinae (Lamiaceae) based on nuclear ITS and ETS, and plastid trnL‐F, trnS‐G, trnD‐T, and matK are presented. The analysis of the ITS dataset included 218 specimens representing 180 species of Hyptidinae. This analysis was used to select a smaller representative sample of 69 species of Hyptidinae for further analysis based on all above regions. The monophyly of Hyptidinae and almost all genera is well‐supported, with noticeable paraphyly of Hyptis which is ancestor of all remaining genera of Hyptidinae. Eriope is monophyletic with the exclusion of E. simplex, while Hypenia represents a monophyletic group excluding H. vitifolia. Hyptis eximia was shown to be associated with Hyptidendron, and Peltodon is embedded within the Hyptis s.str. clade. Internal relationships within Hyptis s.str. were not completely resolved; a preliminary discussion on the taxonomy treatment of the complex and the subdivision of Hyptis are presented.

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Phylogeny of Isodon (Schrad. ex Benth.) Spach (Lamiaceae) and Related Genera Inferred from Nuclear Ribosomal ITS, trnL–trnF Region, and rps16 Intron Sequences and Morphology

Cited by 44 publications

References 39 publications

Selection for High Oridonin Yield in the Chinese Medicinal Plant Isodon (Lamiaceae) Using a Combined Phylogenetics and Population Genetics Approach

Selection for High Oridonin Yield in the Chinese Medicinal Plant Isodon (Lamiaceae) Using a Combined Phylogenetics and Population Genetics Approach

A New Species of <I>Isodon</I> (Lamiaceae, Nepetoideae) from Yunnan Province, Southwest China

Phylogeny of the subtribe Hyptidinae (Lamiaceae tribe Ocimeae) as inferred from nuclear and plastid DNA

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