Phylogeny and evolution of porcine teschovirus 8 isolated from pigs in China with reproductive failure

Lin, Wencheng; Cui, Shangjin; Zell, Roland

doi:10.1007/s00705-012-1315-x

Cited by 24 publications

(15 citation statements)

References 10 publications

(15 reference statements)

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“…In addition, the same serotype isolates were always monophyletic on the tree topology based on the capsid protein sequence. This result is consistent with a previous study showing that PTVs can be easily serotyped based on capsid protein sequences (Lin et al., ; Zell et al., ). Therefore, phylogenetic analyses based on the VP1 and capsid protein genetic sequences were both reliable approaches for PTV serotyping.…”

Section: Discussionsupporting

confidence: 93%

“…The 40 PTV‐HuNs identified consisted of seven of the 13 known PTV serotypes, with a predominance of PTV 4, followed by PTV 2 and PTV 9; this represents the first report of PTV 5, PTV 9 and PTV 11 in China (Lin et al., ; Qiu et al., ; Sun et al., ; Wang et al., ; Zhang et al., ). Although Sun et al.…”

Section: Discussionmentioning

confidence: 75%

“…There are at least 13 distinct serotypes of PTV, including novel serotypes that were recently identified (Boros et al., ; Cano‐Gómez & Jiménez‐Clavero, , ; Cano‐Gómez et al., ; Zell et al., ). In general, PTVs are non‐pathogenic, and infected swine are most often asymptomatic (Knowles, ); however, sporadic cases have been associated with a variety of clinical symptoms, including polioencephalomyelitis, female reproductive disorders, and enteric and respiratory disease (Deng et al., ; Dunne, Gobble, Hokanson, Kradel, & Bubash, ; Knowles, ; Lin, Cui, & Zell, ; Meyer, Woods, & Simon, ; Prodelalova, Malenovska, & Valicek, ; Zhang et al., ). Teschovirus encephalomyelitis, also known as Teschen or Talfan disease, was first reported in Teschen, Czechoslovakia in 1929 (Trefny, ).…”

Section: Introductionmentioning

confidence: 99%

“…At present, a mild form of the disease, with the exception of an outbreak in 2009 in the Republic of Haiti, has been described in many countries (Bangari, Pogranichniy, Gillespie, & Stevenson, ; Deng et al., ; Knowles, ; Pinto, Ankers, Werthmann, & Hamilton, ; Salles et al., ; Takahashi, Seimiya, Seki, & Yamada, ; Wang et al., ; Yamada et al., ; Zhang et al., ). The first documented PTV isolate (Swine/CH/IMH/03) in China was identified in 2003, and some cases and epidemiological studies related to PTV in China have been reported since then (Feng et al., ; Lin et al., ; Qiu, Wang, Zhang, Zhang, & Cui, ).…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology and molecular characterization ofPorcine teschovirusin Hunan, China

Yang

Luo

Yan

et al. 2017

Transbound Emerg Dis

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Porcine teschoviruses (PTVs) have been shown to be widely distributed in pig populations. In this study, 261 faecal and 91 intestinal content samples collected from pigs at 29 farms in Hunan, China, were tested for the presence of PTV by reverse transcription-polymerase chain reaction (RT-PCR). An overall PTV-positivity rate of 19.03% was detected by RT-PCR, and a high PTV infection rate was circulating in asymptomatic fattening and nursery pigs. In total, 40 PTV isolates (PTV-HuNs) were obtained. Alignment of their coding sequences with those of other known PTVs revealed that the genomic sequence of the polyprotein contains 6,606-6,621 nucleotides, encoding a 2,202-2,207-amino acid sequence. Phylogenetic analyses based on the VP1 gene and capsid protein gene exhibited 13 main lineages corresponding to PTV serotypes 1-13, and seven PTV serotypes (PTV 2-6, 9, and 11) were identified in the isolates obtained in our study; this is the first report of PTV 5, 9 and 11 in China. Recombination analysis among the PTV-HuNs indicated that nine recombination events have occurred, including both inter- and intraserotype events. In addition, results demonstrated that only limited positive selection is acting on the global population of PTV isolates, and purifying selection is predominant. In conclusion, this study revealed a high infection rate of PTVs circulating in asymptomatic fattening and nursery pigs. The 40 PTV-HuNs showed high genetic diversity, and genetic analysis of all available PTV sequences revealed that strong purifying selection and recombination play important roles in the genetic diversity and evolution of the virus.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Epidemiology and molecular characterization ofPorcine teschovirusin Hunan, China

Yang

Luo

Yan

et al. 2017

Transbound Emerg Dis

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“…Studies performed in different geographical regions throughout the world revealed that PTV, PSV, and EV-G are ubiquitous and have been reported in Asia (Kaku et al 2007, Lan et al 2011, Lin et al 2012, Moon et al 2012, Zhang et al 2012, Europe (Zell et al 2000, La Rosa et al 2006, Buitrago et al 2010, Sozzi et al 2010, Boros et al 2011, Prodělalová 2012, and the Americas (Bangari et al 2010, Salles et al 2011, Shan et al 2011, Deng et al 2012, Ventura et al 2013, Donin et al 2014.…”

Section: Introductionmentioning

confidence: 99%

Molecular survey of porcine teschovirus, porcine sapelovirus, and enterovirus G in captive wild boars (Sus scrofa scrofa) of Paraná state, Brazil

et al. 2015

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RESUMO.-[Estudo molecular de teschovírus suíno, sapelovírus suíno e enterovírus G em javalis (Sus scrofa scrofa) de cativeiro no Paraná.] Teschovírus suíno (PTV), sapelovírus suíno (PSV) e enterovírus G (EV-G) são agentes infecciosos específicos da espécie suína que estão endemicamente disseminados em todo o mundo. O objetivo deste estudo foi investigar a infecção natural por estes picornavírus entéricos suínos em javalis (Sus scrofa scrofa) do estado do Paraná, Brasil e avaliar pecaris (Pecari tajacu e Tayassu pecari) como hospedeiros alternativos para estes vírus. Amostras fecais (n=36) de javalis assintomáticos (n=22) com idades de 2 a 7 meses (jovens, n=14) e 2 a 4 anos (adultos, n=8) e de pecaris (6 a 8 meses de idade, n=14) foram coletadas em um cativeiro e zoológico, res- Porcine teschovirus (PTV), porcine sapelovirus (PSV), and enterovirus G (EV-G) are infectious agents specific to pig host species that are endemically spread worldwide. This study aimed to investigate the natural infection by these porcine enteric picornaviruses in wild boars (Sus scrofa scrofa) of Paraná state, Brazil, and to evaluate peccaries (Pecari tajacu and Tayassu pecari) as alternative host species for these viruses. Fecal samples (n=36) from asymptomatic wild boars (n=22) with ages ranging from 2 to 7 months old (young, n=14) and 2 to 4 years old (adult, n=8) and from peccaries (6 to 8 months old, n=14) were collected from a farm and a zoo, respectively, both located in Paraná state. Reverse transcription-polymerase chain reaction (RT-PCR) and nested-PCR (n-PCR) assays targeting the 5'non-translated region of the virus genome were used for screening the viruses. Porcine enteric picornaviruses were detected in 12 out of the 22 wild boar fecal samples. According to each of the viruses, EV-G was most frequently (11/22, 50%) detected, followed by PTV (10/22, 45.5%) and PSV (4/22, 18.2%). Regarding the age groups, young wild boars were more frequently (9/14, 64.3%) infected with PTV, PSV, and EV-G than adult animals (3/8, 37.4%). One n-PCR amplified product for each of the viruses was submitted to sequencing analysis and the nucleotide sequences were compared with the related viruses, which showed similarities varying from 97.7% to 100% for PTV, 92.4% to 96.2% for PSV, and 87

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Teschovirus

Malik¹,

Bhat²,

Vlasova³

et al. 2020

Emerging and Transboundary Animal Viruses

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Teschoviruses are emerging pathogens, belonging to the family Picornaviridae, and infects porcine population only. Among all, porcine teschoviruses (PTVs) are of high prominence leading to clinical illness and consequent economic loss to the livestock sector. These are associated with extremely lethal non-suppurative polioencephalomyelitis (Teschen disease) and are distributed world over. Its milder form, Talfan disease, inflicts low morbidity and mortality and general clinical disease. The first epizootics of Teschen disease occurred in 1929 in the Czech Republic. Mature virions are small (23-30 nm) and stable in environmental conditions (pH range 2-9, heat, lipid solvents). Genetic variations in the major surface protein, VP1, lead to the evolution of several new types. As of now, 13

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Phylogeny and evolution of porcine teschovirus 8 isolated from pigs in China with reproductive failure

Cited by 24 publications

References 10 publications

Epidemiology and molecular characterization ofPorcine teschovirusin Hunan, China

Epidemiology and molecular characterization ofPorcine teschovirusin Hunan, China

Molecular survey of porcine teschovirus, porcine sapelovirus, and enterovirus G in captive wild boars (Sus scrofa scrofa) of Paraná state, Brazil

Teschovirus

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