Epidemiology and molecular characterization of<i>Porcine teschovirus</i>in Hunan, China

Yang, Tong; Luo, Binyu; Yan, Meijun; Li, R.; Qu, Tailong; Ren, Xiaohu

doi:10.1111/tbed.12728

Cited by 16 publications

(10 citation statements)

References 36 publications

(82 reference statements)

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“…The subsequent epidemiological investigation showed that PSV was prevalent in southern China. The positive rate of PSV was about 45% in diarrhea samples and 21% in asymptomatic samples ( 7 , 25 ). Phylogenetic analysis showed the isolates in Hunan and Jiangxi varied from previous Chinese strains (cluster I) and formed another cluster (cluster II).…”

Section: Discussionmentioning

confidence: 93%

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Virome Analysis for Identification of a Novel Porcine Sapelovirus Isolated in Western China

et al. 2022

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Section: Discussionmentioning

confidence: 93%

“…More and more information of its circulation in southern China has been provided since then. PSV was frequently detected in fecal samples in Hunan, China ( 7 , 29 ). In 2019, two different PSV strains, JXXY-a2 and JXXY-c, associated with only diarrhea, were isolated in Jiangxi Province ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

Virome Analysis for Identification of a Novel Porcine Sapelovirus Isolated in Western China

et al. 2022

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“…In the history, there were 4 recorded clinical PTV cases showing high mortality, they are 1930s in Czech with PTV-1 [ 7 ], 2009 in Republic of Haiti with PTV-1 [ 18 ], the same year in Dominica Republic with PTV-1 [18] and 2017 in Spain with PTV-13 [ 19 ]. Overall, in China, PTV associated diseases were mostly sporadic and mild and no PTV case showed mortality higher than 10% before [ 1 , 9 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, phylogenetic analysis of VP1 has been used as a reliable approach for characterizing the PTV genotypes [ 1 ]. Also, neutralizing epitopes mainly locate within VP1 and VP2 [ 1 , 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of a novel porcine Teschovirus 2 strain as causative agent of encephalomyelitis in suckling piglets with high mortality in China

Liang

Ding

et al. 2023

BMC Vet Res

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Background Porcine Teschovirus (PTV), also named Teschovirus A, is prevalent in pig populations, mainly causing neurological symptoms, diarrhea, pneumonia, and reproductive failure, however the morbidity and mortality are usually low in pig farms. Case presentation In this study, we reported a PTV outbreak investigation in one large-scale pig farm in China with severe symptoms including diarrhea, lethargy, locomotor ataxia, nystagmus, paralysis of the hind limbs, and coma in piglets. More importantly, the mortality reached 38% in suckling pigs, which is remarkably high in PTV history. A novel PTV strain, named HeNZ1, was isolated from cerebral samples of one suckling pig and the genome sequence was obtained by NGS sequencing. Phylogenetic and evolutionary divergence analyses revealed that HeNZ1 belongs to PTV genotype 2. Surprisingly, the VP1 coding region of HeNZ1 shares the highest sequence similarity with European PTV-2 strains, instead of China domestic PTV-2 strains, implying it may not derive from China local PTV-2 strains. Multiple sequence alignment and B cell epitope prediction of PTV VP1 and VP2 protein revealed 10 B cell epitopes, 5 mutant clusters and 36 unique mutation sites, of which 19 unique mutation sites are located in B cell epitopes and exposed on the surface of VP1 or VP2, implying significant antigenic drift potential of HeNZ1. Conclusion These results indicate that HeNZ1 is a highly virulent PTV-2 strain, which capable of causing severe neurological symptoms and high mortality in piglets. Bioinformatic analysis suggest that HeNZ1 is genetically and antigenically different from other Chinese PTV-2 strains. Overall, current case expanded our understanding of PTV-2 clinical spectrum and revealed the emergence of a highly virulent PTV-2 strain with substantial genetic diversity and antigenic drift potential in VP1 and VP2.

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“…Currently, phylogenetic analyses based on both the VP1 and the P1 gene sequences have proven to be reliable approaches for PTV genotyping (Cano-Gomez, Garcia-Casado, Soriguer, Palero, & Jimenez-Clavero, 2013;Cano-Gómez et al, 2011;Lin et al, 2012;Yang, Yu, et al, 2018b;Zell et al, 2001). Therefore, PTV-positive samples identified in the present study were selected, and their complete VP1 gene was sequenced using five different nested-PCR methods as previously described (Yang, Li, et al, 2018a).…”

Section: Genotype Porcine Teschovirus Species Teschovirus Bmentioning

confidence: 99%

Novel species of Teschovirus B comprises at least three distinct evolutionary genotypes

Yang

Zhang

et al. 2019

Transbound Emerg Dis

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Conventionally, Porcine teschovirus (PTV) consists of 13 genotypes (PTV 1–13, which belong to Teschovirus A); however, several novel members including PTV 14–22 have been discovered recently. PTV 21 was identified as a novel Teschovirus species named Teschovirus B. In this study, almost all 22 reported PTV genotypes except PTV 6, 7, 12 and 20 were identified in the pig populations of western Jiangxi, China, which reflects the high genotype diversity. Moreover, to the best of our knowledge, the nearly complete genome of PTV 22‐JiangX1 was first sequenced in the present study. The homology comparison of the polyprotein genes showed that PTV 22‐JiangX1 shared a relatively high nucleotide and deduced amino acid sequence identities ranging from 78.3% to 82.0% and 84.6% to 89.3%, respectively, with PTV 19 and 21. Additionally, the PTV strain of JiangX1 represents genotype 22 with the PTV 19, and 21 strains proved to be members of Teschovirus B based on the phylogenetic and evolutionary divergence analyses. Finally, we determined that the novel Teschovirus B species comprises at least three PTV genotypes.

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Epidemiology and molecular characterization ofPorcine teschovirusin Hunan, China

Cited by 16 publications

References 36 publications

Virome Analysis for Identification of a Novel Porcine Sapelovirus Isolated in Western China

Virome Analysis for Identification of a Novel Porcine Sapelovirus Isolated in Western China

Identification of a novel porcine Teschovirus 2 strain as causative agent of encephalomyelitis in suckling piglets with high mortality in China

Novel species of Teschovirus B comprises at least three distinct evolutionary genotypes

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