Phylogenetic evaluation of Geomyces and allies reveals no close relatives of Pseudogymnoascus destructans, comb. nov., in bat hibernacula of eastern North America

Minnis, Andrew M.; Lindner, Daniel L.

doi:10.1016/j.funbio.2013.07.001

Cited by 241 publications

(234 citation statements)

References 62 publications

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“…There are no species phylogenetically close related to P. destructans providing evidence to support the hypothesis that this pathogen is non-native and invasive in eastern North America. Additional sampling from other regions of the world is necessary to better understand the evolution and biogeography of this important and diverse group of fungi (Minnis and Lindner 2013). …”

Section: Representative Cold-adapted Fungal Speciesmentioning

confidence: 99%

Living strategy of cold-adapted fungi with the reference to several representative species

et al. 2017

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Our planet is dominant with cold environments that harbour enormously diverse cold-adapted fungi comprising representatives of all phyla. Investigation based on culture-dependent and independent methods has demonstrated that cold-adapted fungi are cosmopolitan and occur in diverse habitants and substrates. They live as saprobes, symbionts, plant and animal parasites and pathogens to perform crucial functions in different ecosystems. Pseudogymnoascus destructans caused bat white-nose syndrome and Ophiocordyceps sinensis as Chinese medicine are the representative species that have significantly ecological and economic significance. Adaptation to cold niches has made this group of fungi a fascinating resource for the discovery of novel enzymes and secondary metabolites for biotechnological and pharmaceutical uses. This review provides the current understanding of living strategy and ecological functions of cold-adapted fungi, with particular emphasis on how those fungi overcome the extreme low temperature and perform their ecological function.

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Section: Representative Cold-adapted Fungal Speciesmentioning

confidence: 99%

Living strategy of cold-adapted fungi with the reference to several representative species

et al. 2017

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“…The latest surveillance and modeling data suggest that WNS is likely to lead to the regional extinction of some bat species in the United States while the disease remains well-tolerated among the European bats [3,4]. Pseudogymnoascus destructans is the fungal causal agent of WNS [5]. Pseudogymnoascus destructans is a psychrophile, well-adapted to growing at 4°-15°C, and widely distributed in the caves and mines that serve as bat hibernacula [5–8].…”

Section: Introductionmentioning

confidence: 99%

“…Pseudogymnoascus destructans is the fungal causal agent of WNS [5]. Pseudogymnoascus destructans is a psychrophile, well-adapted to growing at 4°-15°C, and widely distributed in the caves and mines that serve as bat hibernacula [5–8]. Bats infected with P. destructans exhibit histopathological lesions on wings and other body parts, are frequently aroused from hibernation-induced torpor, and possibly succumb to WNS due to fat depletion and starvation [9–11].…”

Section: Introductionmentioning

confidence: 99%

“…P. pannorum is the nearest fungal relative of P. destructans , which grows over psychrophilic – physiological temperatures, and causes rare skin infections in humans [5,16–18]. We have devoted efforts to create the molecular toolkit for the comparative studies of P. destructans and P. pannorum as there is no framework to investigate fungal pathogenesis at low temperatures.…”

Section: Introductionmentioning

confidence: 99%

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Galleria mellonella experimental model for bat fungal pathogen Pseudogymnoascus destructans and human fungal pathogen Pseudogymnoascus pannorum

et al. 2018

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Laboratory investigations of the pathogenesis of Pseudogymnoascus destructans, the fungal causal agent of bat White Nose Syndrome (WNS), presents unique challenges due to its growth requirements (4°-15°C) and a lack of infectivity in the current disease models. Pseudogymnoascus pannorum is the nearest fungal relative of P. destructans with wider psychrophilic – physiological growth range, and ability to cause rare skin infections in humans. Our broad objectives are to create the molecular toolkit for comparative study of P. destructans and P. pannorum pathogenesis. Towards these goals, we report the successful development of an invertebrate model in the greater wax moth Galleria mellonella. Both P. destructans and P. pannorum caused fatal disease in G. mellonella and elicited immune responses and histopathological changes consistent with the experimental disease.

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“…The fungus Pseudogymnoascus destructans (also called Geomyces destructans) is related to saprophytic coldgrowing species but produces cutaneous infections in bats (Blehert et al, 2009;Minnis and Lindner, 2013). Evidence of this new disease was established in North American in early 2006; infected bats displayed a white fungal growth in mouth, muzzle, ears and wings (Blehert et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Potential for spread of the white-nose fungus (Pseudogymnoascus destructans) in the Americas: use of Maxent and NicheA to assure strict model transference

et al. 2014

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Abstract. Emerging infectious diseases can present serious threats to wildlife, even to the point of causing extinction. Whitenose fungus (Pseudogymnoascus destructans) is causing an epizootic in bats that is expanding rapidly, both geographically and taxonomically. Little is known of the ecology and distributional potential of this intercontinental pathogen. We address this gap via ecological niche models that characterise coarse resolution niche differences between fungus populations on different continents, identifying areas potentially vulnerable to infection in South America. Here we explore a novel approach to identifying areas of potential distribution across novel geographic regions that avoids perilious extrapolation into novel environments. European and North American fungus populations show differential use of environmental space, but rather than niche differentiation, we find that changes are best attributed to climatic differences between the two continents. Suitable areas for spread of the pathogen were identified across southern South America; however caution should be taken to avoid underestimating the potential for spread of this pathogen in South America.

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Phylogenetic evaluation of Geomyces and allies reveals no close relatives of Pseudogymnoascus destructans, comb. nov., in bat hibernacula of eastern North America

Cited by 241 publications

References 62 publications

Living strategy of cold-adapted fungi with the reference to several representative species

Living strategy of cold-adapted fungi with the reference to several representative species

Galleria mellonella experimental model for bat fungal pathogen Pseudogymnoascus destructans and human fungal pathogen Pseudogymnoascus pannorum

Potential for spread of the white-nose fungus (Pseudogymnoascus destructans) in the Americas: use of Maxent and NicheA to assure strict model transference

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