Phylogenetic analysis of a transfusion-transmitted hepatitis A outbreak

Hettmann, Andrea; Juhász, Gabriella; Dencs, Ágnes; Tresó, Bálint; Rusvai, Erzsébet; Barabás, Éva; Takács, Mária

doi:10.1007/s11262-016-1392-0

Cited by 8 publications

(9 citation statements)

References 19 publications

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“…[16,17] Water-borne HAV infections are mainly due to drinking water contaminated by adjacent septic tanks or swimming in water contaminated with sewage. [18,19] Food transmission mainly occurs when the faeces of HAV carriers are transferred to food during food preparation, or when the food plants are contaminated by the faeces of HAV carriers during harvesting or processing. Another modality of the faecal-oral route is extensive and close personal contact between the carrier and the vulnerable person.…”

Section: Discussionmentioning

confidence: 99%

Regional and Age Epidemiological Analysis of Hepatitis A Viral in China, 2004-2017

Xu¹,

Tang²

2021

Preprint

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Background: To describe the prevalence features, including age, regions, morbidity and mortality of hepatitis A viral in China from 2004 to 2017 by searching the China Public Health Sciences Data Center with the keyword “Hepatitis A virus (HAV)”.Methods: In this study, HAV morbidity and mortality data were retrieved from China Public Health Science Data Center (CPHSD) using HAV as a keyword. HAV infection data from 2004 to 2017, HAV cases and HAV-related deaths were retrieved from 31 regions in China, except Taiwan, Hong Kong and Macau. SPSS 18 is used for statistical analysis. GraphPad Prism 5 is used to draw line graphs and histograms. Microsoft PowerPoint 2016 and Adobe Illustrator CS 6 are used for drawing geographically distributed China maps.Results: From 2004 to 2017, the rates of hepatitis A viral morbidity and mortality in China were keeping decrease annually (7.1997 and 3.0772 in 2004; 2.6430 and 0.2997 in 2010; 1.3679 and 0.2899 in 2017, respectively, 1/100,000) (p<0.001). The HAV infection rate of children (0-10 years old) was higher than that of the elderly (>50 years old) (p<0.001). The geographical distribution of HAV prevalence showed significant regional differences which showed that hepatitis A patients were more prevalent in Sichuan and Xinjiang provinces (averaged number >4,000/ year). HAV-related death does not differ much between regions (averaged number 0~2.1/ year)Conclusions: Our analysis of viral hepatitis A prevalence features over past 14 years suggests that the incidence and mortality of HAV are decreased annually in China.

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Section: Discussionmentioning

confidence: 99%

Regional and Age Epidemiological Analysis of Hepatitis A Viral in China, 2004-2017

Xu¹,

Tang²

2021

Preprint

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“…A 41-year-old man, who was a regular apheresis donor, informed the Hungarian National Blood Transfusion Service (HNBTS) of his HAV infection 18 days after his last donation. A 6-year-old boy recipient and his grandmother, the other 65-year-old woman recipient, and one of the nurses in the hospital tested positive for HAV infection [ 99 ]. Nevertheless, in 2018, Lefeuvre et al reported a TAHA infection in an immunocompromised patient in France [ 100 ].…”

Section: Hav Ratementioning

confidence: 99%

Hepatitis A: Viral Structure, Classification, Life Cycle, Clinical Symptoms, Diagnosis Error, and Vaccination

Gholizadeh

Akbarzadeh

Hashemi

et al. 2023

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Hepatitis A virus (HAV) is one of the well-known viruses that cause hepatitis all around the globe. Although this illness has decreased in developed countries due to extensive immunization, numerous developing and under-developed countries are struggling with this virus. HAV infection can be spread by oral-fecal contact, and there are frequent epidemics through nutrition. Improvements in socioeconomic and sanitary circumstances have caused a shift in the disease’s prevalence worldwide. Younger children are usually asymptomatic, but as they become older, the infection symptoms begin to appear. Symptoms range from slight inflammation and jaundice to acute liver failure in older individuals. While an acute infection may be self-limiting, unrecognized persistent infections, and the misapplication of therapeutic methods based on clinical guidelines are linked to a higher incidence of cirrhosis, hepatocellular carcinoma, and mortality. Fortunately, most patients recover within two months of infection, though 10–15% of patients will relapse within the first six months. A virus seldom leads to persistent infection or liver damage. The mainstay of therapy is based on supportive care. All children from 12–23 months, as well as some susceptible populations, should receive routine vaccinations, according to the Centers for Disease Control and Prevention and the American Academy of Pediatrics. Laboratory diagnosis of HAV is based on antigen detection, checking liver enzyme levels, and antibody screening. Furthermore, polymerase chain reaction (PCR) technology has identified HAV in suspected nutrition sources; therefore, this technique is used for preventative measures and food-related laws.

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“…Common source outbreaks associated with contaminated water or food have also been reported, as well as transmission via contaminated blood products [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

“…Faecal–oral, person-to-person spread is the principal mode of transmission in developed countries [4]. Common source outbreaks associated with contaminated water or food have also been reported, as well as transmission via contaminated blood products [5–7].…”

Section: Introductionmentioning

confidence: 99%

Extensive hepatitis A outbreak in an urban childcare facility in Ireland, associated with considerable adult morbidity

O’Connor¹,

McGovern²,

O'Meara³

et al. 2018

Epidemiol. Infect.

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Hepatitis A infection results in a spectrum of illness from asymptomatic disease to severe fulminant hepatitis. Since 2000, <50 cases have been reported annually in Ireland. We report on an outbreak of hepatitis A associated with a childcare facility(CCF) in 2015 in Ireland. Between January and July 2015, 12 outbreak-associated symptomatic hepatitis A cases were identified, including one delayed, retrospective diagnosis. Seven (58%) cases were adults, eight (67%) were male, six of the adults required hospitalisation. All 12 cases were confirmed on serology and the four cases that were genotyped were identical on phylogenetic analysis. Potential environmental exposures and hygiene practices at the CCF were investigated. Outbreak control measures included the provision of: hepatitis A information, infection prevention advice, hepatitis A vaccination to 554 CCF contacts, and voluntary closure of the CCF for deep-cleaning and staff education. From a healthcare perspective 1 , outbreak control costs were in excess of €45 000. This outbreak illustrates the considerable adult morbidity that can occur in hepatitis A outbreaks, highlights the challenges in controlling a large CCF-associated outbreak and the importance of early recognition by clinicians of hepatitis A.

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Phylogenetic analysis of a transfusion-transmitted hepatitis A outbreak

Cited by 8 publications

References 19 publications

Regional and Age Epidemiological Analysis of Hepatitis A Viral in China, 2004-2017

Regional and Age Epidemiological Analysis of Hepatitis A Viral in China, 2004-2017

Hepatitis A: Viral Structure, Classification, Life Cycle, Clinical Symptoms, Diagnosis Error, and Vaccination

Extensive hepatitis A outbreak in an urban childcare facility in Ireland, associated with considerable adult morbidity

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