Phylogenetic analysis of 626 hepatitis E virus (HEV) isolates from humans and animals in China (1986–2011) showing genotype diversity and zoonotic transmission

Full genome analysis of swine genotype 3 hepatitis E virus isolated from eastern China

“…Recent study indicated that the genotype 3 HEV sequences reported from eastern China exhibited high genetic identity (Liu et al, 2012). Similarly, two HEV 3 strains from eastern China, ZhJ-PJ050-3 in this study and SAAS-JDY5 detected from Shanghai, shared a high nucleotide identity of 87.9% at whole genome level.…”

“…Previous study revealed that HEV genotype 4 is the dominant zoonotic HEV genotype in China (Wang et al, 2016a). However, infections with HEV 3 have been found more commonly in recent years in China (Liu et al, 2012;Zhang et al, 2013). To date, only one full genome of Chinese swine genotype 3 HEV strain from Shanghai has been documented (Si et al, 2009).…”

Host Immune Status and Response to Hepatitis E Virus Infection

“…The known animal reservoirs of HEV continue to multiply; novel members of the Hepeviridae have been detected in wild and farmed rabbits, wild rats, birds, bats, and trout (13,15,(88)(89)(90)(91)(92)(93)(94)(95)(96)(97)(98)(99)(100)(101)(102)(103)(104)(105)(106). Of these, only rabbit HEV strains have been shown to share a close phylogenetic relationship and possess antigenic similarity to human-and swine-associated HEV strains.…”

Hepatitis-E-Virus

“…Das virale Genom mit einer Größe von ca. 7,2 kb ist am 5'-Ende methyliert (m 7 G-Cap) und trägt am 3'-Ende eine Poly-A-Sequenz (AA [93].…”