Phylloquinone supplementation improves glycemic status independent of the effects of adiponectin levels in premonopause women with prediabetes: a double-blind randomized controlled clinical trial

Abstract

BackgroundVitamin K, as a cofactor in the gamma carboxylation of certain glutamic acid (Gla) residues, has been related to glucose metabolism and insulin sensitivity. Osteocalcin, also known as bone γ-carboxyglutamic acid, increases β-cell proliferation as well as insulin and adiponectin secretion, which improve glucose tolerance and insulin sensitivity. Thus, the purpose of the present study was to examine the possible role of adiponectin as a mediator of glucose homeostasis following phylloquinone supplementation in premonopause women with prediabetes.MethodsEighty two women were randomized to consume vitamin k1 supplement (n = 39) or placebo (n = 43) for four weeks. Participants in vitamin K1 treatment group received one pearl softgel capsule containing 1000 micrograms phylloquinone while the placebo group received one placebo capsules daily for four weeks. The Blood samples were collected at baseline and after a four-week intervention to quantify osteocalcin, adiponectin, leptin and relevant variables.ResultsPhylloquinone supplementation significantly increased serum adiponectin concentration (1.24 ± 1.90 compared with −0.27 ± 1.08 μg/ml), and did not alter total osteocalcin (0.50 ± 4.11 compared with 0.13 ± 1.85 ng/ml) and leptin (−0.29 ± 8.23 compared with −1.15 ± 5.25 ng/ml) compared with placebo. Adjustments for total osteocalcin and adiponectin using analysis of covariance (ANCOVA) did not affect the association of glycemic status with related variables.ConclusionsIn conclusion our study demonstrated that phylloquinone supplementation improved glycemic status in premonopausal prediabetic women independent of adiponectin.Trial registrationThis trial was registered in Iranian Registry of Clinical Trials with ID number of IRCT2013120915724N1.

Flash Glucose-Sensing Technology as a Replacement for Blood Glucose Monitoring for the Management of Insulin-Treated Type 2 Diabetes: a Multicenter, Open-Label Randomized Controlled Trial

“…Although the reasons for this finding are not entirely clear we hypothesize that the convenience associated with sensor glucose readings, compared with blood glucose testing, prompted more frequent testing. This supports a recent study reporting younger participants as being “too busy” for finger-stick testing [32]. HbA1c level was unchanged for intervention participants ≥65 years.…”

Hypoglycemic action of vitamin K1 protects against early-onset diabetic nephropathy in streptozotocin-induced rats

“…Recent clinical studies have shown that vitamin K1 improves glycemic status in premonopausal women with prediabetes [14]. Studies have also shown that vitamin K1 reduces coronary artery calcification in type 2 diabetic patients [15] and in another study vitamin K1 (phylloquinone) was able to reduce the risk of type 2 diabetes [16].…”

Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis

“…This may be due to differences in the characteristics of participants and in the forms and dosages of vitamin K used. Heterogeneity became nonsignificant when the study by Rasekhi et al32 was excluded ( I 2 =0%, P =0.89). In this study, adiponectin level was significantly increased with vitamin K supplementation 32.…”

“…Heterogeneity became nonsignificant when the study by Rasekhi et al32 was excluded ( I 2 =0%, P =0.89). In this study, adiponectin level was significantly increased with vitamin K supplementation 32. The observed effect may be attributable to osteocalcin, which acts directly on adipocytes, resulting in adiponectin secretion 25–28.…”