Phyllodes Tumour of the Breast: Clinicopathological Analysis of Recurrent vs. Non-recurrent Cases

Bhargav, Panchangam Ramakanth; Mishra, Anjali; Agarwal, Gaurav; Agarwal, Amit; Verma, Amrisha; Mishra, Saroj Kanta

doi:10.1016/s1015-9584(09)60398-5

Cited by 24 publications

(22 citation statements)

References 9 publications

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“…Bhargav et al. proposed that irrespective of the histological grade, WLE is the preferred surgical approach, while mastectomy is required for all recurrent cases. Ben Hassouna et al.…”

Section: Discussionmentioning

confidence: 99%

“…Sotheran et al [9] and Haberer et al [10] highlighted the importance of WLE of breast tumors to control postoperative recurrence in borderline and malignant PTBs. Bhargav et al [11] proposed that irrespective of the histological grade, WLE is the preferred surgical approach, while mastectomy is required for all recurrent cases. Ben Hassouna et al [12] proposed that mastectomy is the preferred surgical approach for malignant PTB.…”

Section: Discussionmentioning

confidence: 99%

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Prognostic factors in breast phyllodes tumors: a nomogram based on a retrospective cohort study of 404 patients

et al. 2018

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The aim of this study was to explore the independent prognostic factors related to postoperative recurrence‐free survival (RFS) in patients with breast phyllodes tumors (PTBs). A retrospective analysis was conducted in Fudan University Shanghai Cancer Center. According to histological type, patients with benign PTBs were classified as a low‐risk group, while borderline and malignant PTBs were classified as a high‐risk group. The Cox regression model was adopted to identify factors affecting postoperative RFS in the two groups, and a nomogram was generated to predict recurrence‐free survival at 1, 3, and 5 years. Among the 404 patients, 168 (41.6%) patients had benign PTB, 184 (45.5%) had borderline PTB, and 52 (12.9%) had malignant PTB. Fifty‐five patients experienced postoperative local recurrence, including six benign cases, 26 borderline cases, and 22 malignant cases; the three histological types of PTB had local recurrence rates of 3.6%, 14.1%, and 42.3%, respectively. Stromal cell atypia was an independent prognostic factor for RFS in the low‐risk group, while the surgical approach and tumor border were independent prognostic factors for RFS in the high‐risk group, and patients receiving simple excision with an infiltrative tumor border had a higher recurrence rate. A nomogram developed based on clinicopathologic features and surgical approaches could predict recurrence‐free survival at 1, 3, and 5 years. For high‐risk patients, this predictive nomogram based on tumor border, tumor residue, mitotic activity, degree of stromal cell hyperplasia, and atypia can be applied for patient counseling and clinical management. The efficacy of adjuvant radiotherapy remains uncertain.

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“…Bhargav et al. proposed that irrespective of the histological grade, WLE is the preferred surgical approach, while mastectomy is required for all recurrent cases. Ben Hassouna et al.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prognostic factors in breast phyllodes tumors: a nomogram based on a retrospective cohort study of 404 patients

et al. 2018

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“…When the diagnosis of a phyllodes tumor with suspicious malignant elements is made, re-excision of the biopsy site to insure complete excision of the tumor with a 1-cm margin of normal-appearing breast tissue is indicated [3].In our case since post operative HPE report came as margin free we proceeded with radiotherapy. Unfortunately, local excision without attention to margins is often performed, particularly since phyllodes tumors are often misdiagnosed as fibroadenomas preoperatively.…”

Section: Discussionmentioning

confidence: 97%

A Case of Malignant Phylloides Tumor Masquerading As Benign Fibroadenoma

Balakrishnan¹,

Latha²,

Dharmarajan³

2017

IOSR JDMS

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“…16 Phyllodes tumors are associated with a risk of recurrence and distant metastases. 17 Preoperative identification of phyllodes tumors is crucial for appropriate surgical planning and prevention of surgical complications resulting from inadequate excision. Mammography and ultrasound examination cannot adequately distinguish between fibroadenomas and phyllodes tumors.…”

Section: Discussionmentioning

confidence: 99%

Cysts within Otherwise Probably Benign Solid Breast Masses and the Risk of Malignancy

Jales

Araújo

Sarian

et al. 2016

Rev Bras Ginecol Obstet

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Objective The objective of this study is to assess whether the largest cyst diameter is useful for BI-RADS ultrasonography classification of predominantly solid breast masses with an oval shape, circumscribed margins, and largest axis parallel to the skin, which, except for the cystic component, would be likely classified as benign. Methods This study received approval from the local institutional review board. From March 2009 to August 2014, we prospectively biopsied 170 breast masses from 164 women. We grouped the largest cyst and mass diameters according to histopathological diagnoses. We used Student's t-test, linear regression, and the area under the receiver operating characteristic curve (AUC) for statistical assessment. Results Histopathological examination revealed 143 (84%) benign and 27 (16%) malignant masses. The mean largest mass diameter was larger among malignant (mean AE standard deviation, 34.1 AE 16.6 mm) than benign masses (24.7 AE 16.7 mm) (P < 0.008). The mean largest cyst diameter was also larger among malignant (9.9 AE 7.1 mm) than benign masses (4.6 AE 3.6 mm) (P < 0.001). Agreement between measurements of the largest mass and cyst diameters was low (R 2 ¼ 0.26). AUC for the largest cyst diameter (0.78) was similar to the AUC for the largest mass diameter (0.69) (p ¼ 0.2). A largest cyst diameter < 3, ! 3 to < 11, and ! 11 mm had a positive predictive value of 0, 15, and 52%, respectively. Conclusion A largest cystic component < 3 mm identified within breast masses that show favorable characteristics may be considered clinically inconsequential in ultrasonography characterization. Conversely, masses with a largest cystic component ! 3 mm should be classified as BI-RADS-US category 4.

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Phyllodes Tumour of the Breast: Clinicopathological Analysis of Recurrent vs. Non-recurrent Cases

Abstract: WLE seems to be the initial procedure of choice for all PTs, and mastectomy for recurrent tumours. Further studies are needed to define the role of adjuvant therapies.

Cited by 24 publications

References 9 publications

Prognostic factors in breast phyllodes tumors: a nomogram based on a retrospective cohort study of 404 patients

Prognostic factors in breast phyllodes tumors: a nomogram based on a retrospective cohort study of 404 patients

A Case of Malignant Phylloides Tumor Masquerading As Benign Fibroadenoma

Cysts within Otherwise Probably Benign Solid Breast Masses and the Risk of Malignancy

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