Phyllodes tumors in African American women

Bumpers, Harvey L.; Tadros, Talaat S.; Gabram-Mendola, Sheryl; Rizzo, M.; Martin, Mersadies; Zaremba, Nicole; Okoli, Joel

doi:10.1016/j.amjsurg.2014.09.040

Cited by 16 publications

(21 citation statements)

References 30 publications

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“…[ 11 ] However, previous studies have reported more frequent occurrence of malignant PT in older patients with mean age of 45 to 54. [ 1 , 15 ] In contrast, we found slightly higher age group presenting with borderline PT (mean age of 51.1 years) compared to benign and malignant as seen in another study. [ 16 ]…”

Section: Discussioncontrasting

confidence: 62%

“…Several other studies also showed that there were higher incidence of PT among a certain ethnic group compared to others in their region, namely among the African American and the Hispanics in the United States. [ 1 , 11 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 4 , 17 , 18 ] Two studies however, described a left dominance pattern of 71% and 58%, respectively. [ 1 , 16 ] Clinical data on menarche, menopause, hormone history, or pregnancies were sparse. However, a local study by Yen-Fa et al [ 19 ] showed that pregnancy status, breast feeding history, hormonal contraception history, and family history of breast cancer or laterality of tumor were not significantly different between the benign, borderline and malignant PTs.…”

Section: Discussionmentioning

confidence: 99%

“…Phyllodes tumor (PT) of the breast is a rare fibroepithelial neoplasm representing <1% of all mammary tumors. [ 1 – 3 ] The name phyllodes originates from Latin (phyllodium) and Greek (phullōdēs) which mean leaf-like or flattened leafstalk. Histologically, it is characterized by large leaf-like (phyllodes) projections with high degree of increased stromal proliferation and cellularity as compared to fibroadenoma.…”

Section: Introductionmentioning

confidence: 99%

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Radiopathological characteristics and outcomes of phyllodes tumor of the breast in Malaysian women

et al. 2018

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Phyllodes tumor or cystosarcoma phyllodes is a rare fibroepithelial neoplasm which arises from the periductal stroma of the breast. They are classified as benign, borderline, and malignant based on the histologic features. However, all phyllodes tumor (PT) subtypes are regarded as having malignant potential and correct diagnosis is important for surgical management and optimal care. This study is a retrospective review of 76 women diagnosed as PT with highlights on the imaging characteristics, pathology, and surgical treatment over a 7-year period in a tertiary medical center of urban population in Malaysia. There were 45 benign, 16 borderline, and 15 malignant PT. The median age for benign PT was 43, borderline 48.5, and malignant 42 years. The Malay ethnic group constitute 52.6% of cases, with 27.6% and 18.4% in Chinese and Indian ethnic groups, respectively. On mammograms, most benign (64.3%) and 33.3% of malignant PT showed high-density lesions. Calcifications were only seen in 2 benign PT. On ultrasound, 86% of benign PT was well-circumscribed whilst 50.0% of malignant PT had irregular outline. Cystic spaces were seen in 40.0% of malignant and 9.5% of benign PT. 80% of malignant PT lesions were heterogenous. Malignant PT demonstrates tumor heterogeneity, cystic spaces, and posterior acoustic enhancement on ultrasound. Half of malignant PT showed regular borders on ultrasound and appear well circumscribed on mammogram. A total of 46 patients had wide local excision or excision biopsy whilst 30 underwent mastectomy as primary treatment. The majority of the borderline and malignant PTs in our study (75.0% and 85.7% respectively) and only 5 out of the 43 (11.6%) benign PT underwent mastectomy. There were 2 tumor recurrence in the benign PT group and 1 case in the borderline and malignant group respectively.

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Section: Discussioncontrasting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Radiopathological characteristics and outcomes of phyllodes tumor of the breast in Malaysian women

et al. 2018

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“…The terminology of phyllodes tumors has been adopted by the World Health Organization (WHO), which recommends that the tumors be classified as benign, malignant, or borderline according to their pathological features [ 3 ]. Though the phyllodes tumors always occur in females, but several cases were found in male patients that were diagnosed with gynecomastia [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Surgical excision and oncoplastic breast surgery in 32 patients with benign phyllodes tumors

et al. 2018

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BackgroundThe purpose of this study was to assess the effectiveness and safety in patients with benign phyllodes after performing local excision and following with intra-operative breast flap reconstruction.MethodsPatients (n = 32) with eligible breast cystosarcoma phyllodes underwent wide local excision followed by intra-operative breast flap reconstruction. Primary outcome measures included average operative time, length of in-hospital stay, postoperative recurrence, and intra-operative and postoperative complications.ResultsThirty-two patients who underwent surgical excision and oncoplastic breast surgery were evaluated using the BCCT.core software. A satisfactory symmetrical breast shape was achieved. The average operative time was 56.3 ± 8.2 min. The average postoperative duration of hospitalization was 3.7 ± 1.2 days. While there was no breast disease recurred during the 1 to 8-year follow-up period.ConclusionsWide local excision accompanied by intra-operative breast flap reconstruction could be adopted for removing benign phyllodes tumors while retaining the basic shape of the breast.

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Racial‐ethnic variations in phyllodes tumors among a multicenter United States cohort

Nash

Thomas

Nimbkar

et al. 2022

Journal of Surgical Oncology

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Background and objectives: Previous studies have identified racial-ethnic differences in the diagnostic patterns and recurrence outcomes of women with phyllodes tumors (PT).However, these studies are generally limited in size and generalizability. We therefore sought to explore racial-ethnic differences in age, tumor size, subtype, and recurrence in a large US cohort of women with PT. Methods:We performed an 11-institution retrospective review of women with PT from 2007 to 2017. Differences in age at diagnosis, tumor size and subtype, and recurrence-free survival according to race-ethnicity.Results: Women of non-White race or Hispanic ethnicity were younger at the time of diagnosis with phyllodes tumor. Non-Hispanic Other women had a larger

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Phyllodes tumors in African American women

Cited by 16 publications

References 30 publications

Radiopathological characteristics and outcomes of phyllodes tumor of the breast in Malaysian women

Radiopathological characteristics and outcomes of phyllodes tumor of the breast in Malaysian women

Surgical excision and oncoplastic breast surgery in 32 patients with benign phyllodes tumors

Racial‐ethnic variations in phyllodes tumors among a multicenter United States cohort

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