Phyllodes Tumor: an Unexpected Tumor of the Breast

Stranzl, Heidi; Peintinger, Florentia; Hackl, A.

doi:10.1007/s00066-004-1182-9

Cited by 4 publications

(5 citation statements)

References 16 publications

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“…After a thorough review of abstracts and exclusion of duplicated references, 46 studies were treated as candidates. Further examination of the manuscripts led to the inclusion of 17 radiotherapy studies for meta-analysis [3,9,[12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]. The literature search flow chart is displayed in Fig.…”

Section: Search Resultsmentioning

confidence: 99%

“…Despite these data, no well-established adjuvant therapy applies to high grade phyllodes tumors, which is partly due to the controversial roles of adjuvant radiotherapy and chemotherapyl [8]. The use of radiotherapy lacks sufficient prospective study data regarding borderline and malignant PT [9], while the adoption of chemotherapy is yet to solve the rarity of disease presentation [10]. Furthermore, no randomized clinical trials of chemotherapy and/or radiation therapy have been published.…”

Section: Introductionmentioning

confidence: 99%

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Adjuvant radiotherapy and chemotherapy for patients with breast phyllodes tumors: a systematic review and meta-analysis

Xue

Chen

Zeng³

et al. 2019

BMC Cancer

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Background: As the efficacy of radiotherapy and chemotherapy for treatment of phyllodes tumors (PTs) remains unclear, this study aimed to review all available data and evaluate the roles of radiotherapy and chemotherapy in PT treatment. Methods: We performed a comprehensive search of databases, including PubMed, Web of Science and the Cochrane Library. The outcomes of interest included the local recurrence (LR) rate, metastasis rate, disease-free survival rate and overall survival rate. Results: Seventeen studies enrolling 696 patients were included in this random effect meta-analysis. Subgroup analysis and meta-regression were also conducted to determine study heterogeneity. A pooled local recurrence rate of 8% (95% CI: 1-22%) was observed with a statistical heterogeneity of I 2 = 86.6% (p < 0.01) for radiotherapy. This was lower than the recurrence rate of 12% for simple surgical treatment (95% CI: 7-18%). Meta-regression analysis found that surgical margin status was the main source of heterogeneity (p = 0.04). The metastasis rate of 4% (95% CI: 0-11%) for patients receiving radiotherapy without significant heterogeneity was also lower than the rate for the simple surgery group (8, 95% CI: 3-15%). The available data for chemotherapy were too limited to support meta-analysis. Accordingly, we offer a pure review of these data. Conclusion: Our findings suggest that radiotherapy is effective in achieving local disease control and preventing metastasis.

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Section: Search Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adjuvant radiotherapy and chemotherapy for patients with breast phyllodes tumors: a systematic review and meta-analysis

Xue

Chen

Zeng³

et al. 2019

BMC Cancer

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“…[6] 821 Malignant and borderline histology EQUIVOCAL Saumarova'R et al [8] 25 Malignant histology YES Stranzl H et al [9] 06 Malignant histology YES Erhan Y et al [10] 21 high mitotic rate, p53 and Ki-67 fraction YES…”

Section: Resultsmentioning

confidence: 99%

Largest Phyllodes Tumor- Case Report and Brief Review Article

Kumar

Patel

Bhargavan

et al. 2011

Indian J Surg Oncol

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This is an article reporting the largest phyllodes tumor and the role of radiotherapy in patients of phyllodes tumor of breast, based on Medline search for articles in English language using keywords "role of radiotherapy in phyllodes tumor of breast". 32 years female presented with a lump in right breast since last 4 months. This was the second recurrence of similar lump in last 6 years. Biopsy from the lump proved to be cystosarcoma phyllodes. Radical Mastectomy with level I node sampling and reconstruction with Latissimus Dorsi Myocutaneous flap was done as a curative procedure. The tumor measured exactly to be 50×25.2×16.4 cm in size and 15 kg in weight. Proliferation markers like Ki-67 and p53 were in the range of 1-2% and 3-4% respectively. Histopathological diagnosis of the tumor was borderline phyllodes tumor. Patient had an uneventful postoperative course and is presently on three monthly follow up since 1 year.

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“…The value of postoperative adjuvant treatments for MPTB, such as radiotherapy (RT), has also been controversial. There are insufficient data from prospective studies on radiotherapy for the treatment of PTB [ 7 ]. A previous study concluded that patients with malignant lobular tumors who received adjuvant radiotherapy had worse survival outcomes compared to those who did not receive adjuvant radiotherapy [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of adjuvant radiotherapy on overall survival and breast cancer-specific survival of patients with malignant phyllodes tumor of the breast in different age groups: a retrospective observational study based on SEER

Yang,

Zhang,

Zhang

et al. 2024

Radiat Oncol

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Purpose Malignant phyllodes tumor of the breast (MPTB) is a rare type of breast cancer, with an incidence of less than 1%. The value of adjuvant radiotherapy (RT) for MPTB has been controversial. The aim of the study was to explore the effect of radiotherapy on the long-term survival of female patients with MPTB at different ages. Methods Female MPTB patients were selected from the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2020. A Kaplan–Meier survival analysis was conducted to investigate the value of RT for the long-term survival of MPTB patients in different age groups. Additionally, univariate and multivariate Cox regression analyses were performed for overall survival (OS) and breast cancer-specific survival (BCSS) of MPTB patients. Furthermore, propensity score matching (PSM) was also performed to balance the differences in baseline characteristics. Results 2261 MPTB patients were included in this study, including 455 patients (20.12%) with RT and 1806 patients (79.88%) without RT. These patients were divided into four cohorts based on their ages: 18–45, 46–55, 56–65, and 65–80. Before adjustment, there was a statistically significant difference in long-term survival between RT-treated and non-RT-treated patients in the younger age groups (age group of 18–45 years: OS P = 0.019, BCSS P = 0.016; age group of 46–55 years: OS P < 0.001, BCSS P < 0.001). After PSM, no difference was found in long-term survival of patients in both younger and older groups regardless of whether they received RT (age group of 18–45 years: OS P = 0.473, BCSS P = 0.750; age group of 46–55 years: OS P = 0.380, BCSS P = 0.816, age group of 56–65 years: OS P = 0.484, BCSS P = 0.290; age group of 66–80 years: OS P = 0.997, BCSS P = 0.763). In multivariate COX regression analysis, RT did not affect long-term survival in patients with MPTB. Conclusion There is no evidence that long-term survival of MPTB patients in specific age groups can benefit from RT.

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Phyllodes Tumor: an Unexpected Tumor of the Breast

Cited by 4 publications

References 16 publications

Adjuvant radiotherapy and chemotherapy for patients with breast phyllodes tumors: a systematic review and meta-analysis

Adjuvant radiotherapy and chemotherapy for patients with breast phyllodes tumors: a systematic review and meta-analysis

Largest Phyllodes Tumor- Case Report and Brief Review Article

Effect of adjuvant radiotherapy on overall survival and breast cancer-specific survival of patients with malignant phyllodes tumor of the breast in different age groups: a retrospective observational study based on SEER

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