Phyllanthus emblica L. (amla) branch: A safe and effective ingredient against skin aging

Abstract

Background and aim Skin aging influences the changes in skin, including skin dryness, wrinkle, and irregular pigmentation. Amla ( Phyllanthus emblica L.) branch has shown several benefits, but not the anti-skin aging. The study aimed to evaluate the anti-skin aging efficacy of amla branch. Experimental procedure Amla branches were standardized the phenolic acids. The extract was investigated anti-skin aging activities, including antioxidant, anti-tyrosinase, anti-melanogenesis, and matrix metalloproteinase-2 inhibitory assays. Topical gel containing extract was prepared and evaluated the skin irritation by a single closed patch test. Randomized, double-blind, placebo-control study was performed in 20 volunteers for 84 consecutive days. The tested skin was evaluated by Chromameter® CR 400, Dermalab® USB, Mexameter® MX 18, Corneometer® CM 825, and Visioscan® VC 98. Results Amla branch extract, a dark brown powder, consisted a variety of phenolic acids, mainly sinapic and ferulic acids. The extract exhibited the potent antioxidant and tyrosinase inhibitory activities in vitro assays and the melanin suppression through inhibition of tyrosinase and tyrosinase-related protein-2 activities, the strong antioxidant, and the potent matrix metalloproteinase-2 in cellular assays at 0.1 mg/mL. Topical gel containing 0.1% extract was a stable and safe formulation. Clinical study was proved the superior anti-skin aging efficacy, including the lightening skin color, the enhanced skin elasticity and hydration, and the skin wrinkle reduction. Conclusion The study results suggested that amla branch is a rich source of bioactive compounds and can be a potential ingredient for utilization in anti-skin aging products.

Modulation of psoriatic-like skin inflammation by traditional Indian medicine Divya-Kayakalp-Vati and Oil through attenuation of pro-inflammatory cytokines

“… 32 , 33 Herbal components of DKV such as Phyllanthus emblica L., Curcuma longa L. contain phytochemicals that have anti-inflammatory and antioxidant activities against skin inflammation. 34 , 35 , 36 In our study, phytochemicals such as Gallic acid, Catechin, Berberine, Curcumin, Phenol, and Benzoic acid were found to be present in both DKV and DKO. Gallic acid can modulate the NADPH-oxidase activity in polymorphonuclear leukocytes associated with induction of oxidative stress through reactive oxygen species generation.…”

Review on oral plant extracts in Skin Whitening

“…Nowadays, many of these oral plant-based natural sources extracts are mostly from Asian origin. These compounds of oral functional plant selected as tyrosinase inhibitors by extraction (Kim et al, 2022;Smit et al, 2009) (Avianggi et al, 2022;Chaikul et al, 2021;Chaiyana et al, 2020;Chen et al, 2022;Khettal et al, 2017;Kim et al, 2022;Lianza et al, 2020;Omar et al, 2018;Setyawati et al, 2018;Truong et al, 2017;Wang et al, 2021a;Zeitoun et al, 2020). At present, oral plant extracts are more studied on plant extracts with good taste and good effective.…”

Case study: Awareness of indigenous knowledge associated with traditional herbs for health and sustainable development

“…There are number of medicinal herbs includes basil (ocimumbasilicum), aloe vera (Aloe barbadensis), garlic (Allium sativum), neem (Azadirachtaindica), fenugreek leaves (Trigonellafoenumgraecum) and amla (Phyllanthusemblica) that represents several properties includes anticancer, gastric ulceration, antioxidant, cytoprotective, immunomodulatory and cardiac stimulatory activities [7][8][9][10][11][12]. Mainstreaming of herbshas been found essential to detect medicinal properties and desired potential genotypes for enhancement the economic importance and agricultural improvement.…”