Phyllanthus amarus and hepatitis B

Thyagarajan, S P; Jayaram, S.; Valliammai, T.; Madanagopalan, N; Pal, Vishnu; Jayaraman, Kunthala

doi:10.1016/0140-6736(90)92328-f

Cited by 57 publications

(38 citation statements)

References 3 publications

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“…In another study involving 60 chronically HBV infected patients, Thyagarajan et al reported that treatment of 200 mg of P. niruri herbs powder three times a day for 30 days resulted in seroconversion of HBsAg (59% vs. 4%, in Phyllanthus and placebo groups, respectively) within 15-20 days after the end of treatment and the HBsAg were still negative after 90 days of evaluation. In summary, this descriptive preliminary study concluded that P. niruri extract at a dose of 2 times 100 mg daily for 12 weeks has not yet demonstrated its benefits in terms of HBeAg clearance and ALT normalization [17].…”

Section: Chronic Hepatitis Bmentioning

confidence: 99%

“…niruri has scientifically been studied and evaluated in various clinical trials on infectious diseases, such as chronic hepatitis B [17,18], pulmonary tuberculosis (TB) [19][20][21][22], vaginitis [23], as well as varicella-zoster infection [24]. In such diseases, the effective immune system is crucial to the treatment success and eradication of the pathogens.…”

Section: A Rt I C L E I N F O Abstractmentioning

confidence: 99%

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The use of Phyllanthus niruri L. as an immunomodulator for the treatment of infectious diseases in clinical settings

Tjandrawinata¹,

Susanto²,

Nofiarny³

2017

APJTD

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Section: Chronic Hepatitis Bmentioning

confidence: 99%

Section: A Rt I C L E I N F O Abstractmentioning

confidence: 99%

The use of Phyllanthus niruri L. as an immunomodulator for the treatment of infectious diseases in clinical settings

Tjandrawinata¹,

Susanto²,

Nofiarny³

2017

APJTD

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“…Lignins like phyllanthin and hypophyllanthin, flavonoids like quercetin and astragalin, ellagitannins like amarinic acid and hydrolyzable tannins like phyllanthisiin D isolated from this plant were reported to possess antioxidative properties [42]. Chanca Piedra can detoxify the free radicals and has an antioxidant activity and increase the rate of regeneration of necrosed cells [43,44]. However, the use of these herb is limited by side effects.…”

Section: Histological Analysismentioning

confidence: 99%

Histomorphological Changes in Kidney Associated with the Ethanolic Extracts of the Leaves of <i>Phyllanthus amarus</i> in Cadmium Induced Kidney Damage in Experimental Animals

Olubunmi¹,

Yinka²,

Oladele³

et al. 2017

IJCDA

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Abstract:Heavy metal poisoning is often as a result of prolonged occupational or domestic exposure to toxic metals and it is difficult to treat it immediately as the effects manifest over time. The use of herbal medicines and phytonutrients continues to expand rapidly across the world with many people now resorting to these products for treatment of various health challenges in different national healthcare settings. Chanca Piedra is a plant that has proven useful in assisting the treatment of various diseases. There have also been controversial claims on the effects of the plant on kidney stones and gall stones. Since cadmium is a very common nephrotoxic agent to which humans and animals are exposed frequently, this study has the potential to provide insight into the possible prophylactic and ameliorative effects of Chanca Piedra on kidney damage and it may also help in providing solutions to the problem of cadmium nephrotoxicity. The present study was carried out to investigate the prophylactic and ameliorative effects of orally administered ethanolic extract of Chanca Piedra (CP) (Phyllantus amarus) against nephrotoxicity produced by cadmium (40mg/kg BW) sulphate in adult male Wistar rats (Rattus novegicus). Forty-two (42) adult male Wistar rats were used in this study and were divided into seven (7) groups of (n=6) as follows: Group A (control), Group B (40mg/kg BW), Group C (100mg/kg BW of CP + 40mg/kg BW), Group D (200mg/kg BW of CP + 40mg/kg BW), Group E (40mg/kg BW + 100mg/kg BW of CP), Group F (40mg/kg BW + 200mg/kg BW of CP), Group G (200mg/kg BW of CP). Both cadmium and Chanca piedra were administered orally through oro-gastric cannula. The animals were sacrificed 24 hours after the last administration through cervical dislocation and blood samples were collected through cardiac puncture for analysis of superoxide dismutase and glutathione peroxidase and the kidney were fixed in 10% formal saline for 24hrs and then processed for histological analysis. Histological analysis using H&E stain for general histoarchitecture and Masson's Trichrome for collagen fibres, indicated alterations in cell morphology of all the treated groups. The findings indicated that the administration of CP extract has no prophylactic or ameliorative effects on Cd-induced kidney damage and that CP had observable adverse effects on the kidneys of adult Wistar rats.

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“…Medicinal plants with strong antiviral activity to treat viral infections in humans and animals have been identified and those containing novel plant-derived antiviral agents with complementary and overlapping mechanisms of action have been studied (Venkateswaran et al, 1987;Hudson 1990;Thyagarajan et al, 1990;Chattopadhyay and Naik, 2007). Medicinal plants are progressively being explored as appropriate alternative sources for discovery of antiviral agents (Williams, 2001;Jassim and Naji, 2003;Camargo Filho et al 2008;Lupini et al 2009, Choi, et al, 2009) and more research is ongoing.…”

Section: Introductionmentioning

confidence: 99%

The antiviral activity of six South African plants traditionally used against infections in ethnoveterinary medicine

Bagla

McGaw

Eloff

2012

Veterinary Microbiology

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Viral infections remain a major threat to humans and animals and there is a crucial need for new antiviral agents especially with the development of resistant viruses. The hexane, dichloromethane, acetone and methanol extracts of six plant species selected for their traditional use against infections were tested for in vitro antiviral activity against canine distemper virus (CDV), canine Parainfluenza virus-2 (CPIV-2), feline herpesvirus-1 (FHV-1) and lumpy skin disease virus (LSDV). All extracts were tested for their cytotoxicity using a colorimetric tetrazolium-based (MTT) assay and were tested for antiviral efficacy at concentrations below CC50 values on the various cell types used in the study. The antiviral activity of extracts was tested using virucidal and attachment assays. In the virucidal assay, extracts were incubated with virus prior to infection. The most potent inhibition was observed with the acetone and methanol extracts of Podocarpus henkelii against CDV and LSDV, which inhibited replication of the viruses by >75% at 3 ug/ml with selectivity index (SI) values ranging between 12 and 45. Excellent activity was also found with the hexane extracts of Plumbago zeylanica and Carissa edulis against CDV, with the extracts reducing viral-induced CPE by 50% and 75% respectively. The 2 hexane extract of Carissa edulis had moderate activity against FHV-1 with EC50 <70 ug/ml and SI value <2. Only the acetone extract of Podocarpus henkelii moderately inhibited replication of LSD virus in the attachment assay, with low activity in other extracts. Of the four extracts with significant antiviral activity, two were prepared from Podocarpus henkelii. Therefore, future work will focus on isolating and characterizing the substance(s) responsible for bioactivity in extracts of this species.

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Phyllanthus amarus and hepatitis B

Cited by 57 publications

References 3 publications

The use of Phyllanthus niruri L. as an immunomodulator for the treatment of infectious diseases in clinical settings

The use of Phyllanthus niruri L. as an immunomodulator for the treatment of infectious diseases in clinical settings

Histomorphological Changes in Kidney Associated with the Ethanolic Extracts of the Leaves of <i>Phyllanthus amarus</i> in Cadmium Induced Kidney Damage in Experimental Animals

The antiviral activity of six South African plants traditionally used against infections in ethnoveterinary medicine

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Phyllanthus amarus and hepatitis B

Cited by 57 publications

References 3 publications

The use of Phyllanthus niruri L. as an immunomodulator for the treatment of infectious diseases in clinical settings

The use of Phyllanthus niruri L. as an immunomodulator for the treatment of infectious diseases in clinical settings

Histomorphological Changes in Kidney Associated with the Ethanolic Extracts of the Leaves of &lt;i&gt;Phyllanthus amarus&lt;/i&gt; in Cadmium Induced Kidney Damage in Experimental Animals

The antiviral activity of six South African plants traditionally used against infections in ethnoveterinary medicine

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Histomorphological Changes in Kidney Associated with the Ethanolic Extracts of the Leaves of <i>Phyllanthus amarus</i> in Cadmium Induced Kidney Damage in Experimental Animals