Phthalate occurrence in rivers and tap water from central Spain

Domínguez-Morueco, Noelia; González-Alonso, S.; Valcárcel, Y.

doi:10.1016/j.scitotenv.2014.08.098

Cited by 113 publications

(39 citation statements)

References 31 publications

(43 reference statements)

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“…However, the present results were similar to most of the reports on phthalate esters in source water in China and in other countries . The phthalate ester concentrations in drinking water in the present study were similar to those in previous studies but much lower than those reported by Tang et al .…”

Section: Resultssupporting

confidence: 92%

“…However, the present results were similar to most of the reports on phthalate esters in source water in China and in other countries [2,[21][22][23][24][25][26][27][28][29][30]. The phthalate ester concentrations in drinking water in the present study were similar to those in previous studies [20,29,31,32] Table S3). In addition to the dimethyl phthalate found in the dry season, bis-2-n-butoxyethyl phthalate and dicyclohexyl phthalate detected in the wet season were not detected in the dry season.…”

Section: Phthalate Ester Occurrence and Compositionsupporting

confidence: 92%

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Phthalate esters in main source water and drinking water of Zhejiang Province (China): Distribution and health risks

Wang

Lou

Zhang

et al. 2015

Enviro Toxic and Chemistry

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To evaluate the distributions and health risks of phthalate esters in the main source water and corresponding drinking water of Zhejiang Province, the concentrations of 16 phthalate esters in water samples from 19 sites were measured from samples taken in the dry season and wet season. The concentration of the total phthalate ester congeners in source water ranged from 1.07 μg/L to 7.12 μg/L in the wet season, from 0.01 μg/L to 1.58 μg/L in the dry season, from 1.18 μg/L to 15.28 μg/L from drinking water in the wet season, and from 0.16 μg/L to 1.86 μg/L from drinking water in the dry season. Of the 16 phthalate esters, dimethyl phthalate, dibutyl phthalate, di-(2-ethyl-hexyl) phthalate, di-iso-butyl phthalate, bis-2-n-butoxyethyl phthalate, and dicyclohexyl phthalate were present in the samples analyzed, dominated by di-iso-butyl phthalate and di-(2-ethyl-hexyl) phthalate. The concentrations of phthalate esters in the wet season were all relatively higher than those in the dry season, and the drinking water had higher concentrations of phthalate esters than source water. The phthalate ester congeners studied pose little health risk to nearby citizens. Environ Toxicol Chem 2015;34:2205-2212. © 2015 SETAC.

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Section: Resultssupporting

confidence: 92%

Section: Phthalate Ester Occurrence and Compositionsupporting

confidence: 92%

Phthalate esters in main source water and drinking water of Zhejiang Province (China): Distribution and health risks

Wang

Lou

Zhang

et al. 2015

Enviro Toxic and Chemistry

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“…BBP is an external plasticizer, i.e., used in resin softening without chemical binding to the final product. Therefore, BBP tends to migrate slowly out of discarded plastics and disperse into aqueous environments 8, 9 ; hence, BBP may enter the food chain 10 . In addition, phthalates have been classified as endocrine-disrupting chemicals (EDCs) and may interfere with the endocrine system to produce adverse developmental, reproductive, neurological, and immunological effects 11–13 .…”

Section: Introductionmentioning

confidence: 99%

Benzyl butyl phthalate decreases myogenic differentiation of endometrial mesenchymal stem/stromal cells through miR-137-mediated regulation of PITX2

Chen

Hsu

Chang

et al. 2017

Sci Rep

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Phthalate, an environmental toxin, has been considered as an endocrine-disrupting chemical. Growing evidence has demonstrated links between endocrine-disrupting chemicals, tissue development, and reproductive physiology, but the mechanisms of gene expression regulation by environmental factors that affect cell differentiation are unclear. Herein, we investigated the effects of butyl benzyl phthalate (BBP) on human endometrial mesenchymal stem/stromal cell (EN-MSC) differentiation and identified a novel signaling pathway. Differentiation of endometrial mesenchymal stem/stromal cells decreased after administration of BBP. We analyzed BBP regulation of gene expression in EN-MSC using cDNA microarrays and Ingenuity Pathway Analysis software to identify affected target genes and their biological functions. PITX2 emerged as a common gene hit from separate screens targeting skeletal and muscular disorders, cell morphology, and tissue development. BBP decreased transcription of PITX2 and elevated expression of the microRNA miR-137, the predicted upstream negative regulator of PITX2. These data indicated that BBP affects PITX2 expression through miR-137 targeting of the 3′ untranslated region of PITX2 mRNA. PITX2 down-regulation also decreased MyoD transcript levels in EN-MSC. Our results demonstrate that BBP decreases EN-MSC myogenic differentiation through up-regulation of miR-137, contribute to our understanding of EN-MSC differentiation, and underline the hazardous potential of environmental hormones.

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“…Phthalates have been investigated in different environmental compartments mainly in water, and sediments and soils [90,91]. Table 10 summarizes MAE-based methodologies.…”

Section: Phthalatesmentioning

confidence: 99%

Microwave-assisted extraction of emerging pollutants in environmental and biological samples before chromatographic determination

Sánchez-Prado

Garcı́a-Jares

Dagnac³

et al. 2015

TrAC Trends in Analytical Chemistry

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Phthalate occurrence in rivers and tap water from central Spain

Cited by 113 publications

References 31 publications

Phthalate esters in main source water and drinking water of Zhejiang Province (China): Distribution and health risks

Phthalate esters in main source water and drinking water of Zhejiang Province (China): Distribution and health risks

Benzyl butyl phthalate decreases myogenic differentiation of endometrial mesenchymal stem/stromal cells through miR-137-mediated regulation of PITX2

Microwave-assisted extraction of emerging pollutants in environmental and biological samples before chromatographic determination

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