Phthalate-induced oxidative stress and association with asthma-related airway inflammation in adolescents

Franken, Carmen; Lambrechts, Nathalie; Govarts, Eva; Koppen, Gudrun; Hond, Elly Den; Ooms, Daniëlla; Voorspoels, Stefan; Bruckers, Liesbeth; Loots, Ilse; Nelen, Vera; Sioen, Isabelle; Nawrot, Tim S.; Baeyens, Willy; Larebeke, Nicolas Van; Schoeters, Greet

doi:10.1016/j.ijheh.2017.01.006

Cited by 76 publications

(36 citation statements)

References 72 publications

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“…Our findings may contribute to action plans aimed at improving indoor air quality and decreasing EDCs exposure, thereby improving children's health. This study assessed the effect of individual exposure and co‐exposure to VOC identified as EDCs; however, most previous studies have focused primarily on the effects of exposure to individual semi‐volatile organic compounds such as phthalates and bisphenol on respiratory health and obesity in children and on compounds that interact with the oestrogen, androgen and thyroid hormone systems . Our results suggested that exposure to individual or combined EDCs may interfere with other systems, increasing the risk of asthma, the presence of respiratory symptoms in the previous 3 months and obesity in schoolchildren, and these results contribute to the understanding of the potential health risk of co‐exposure.…”

Section: Discussionmentioning

confidence: 81%

Exposure to indoor endocrine‐disrupting chemicals and childhood asthma and obesity

Paciência

Rufo

Silva

et al. 2019

Allergy

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Background: Indoor air contaminants may act as endocrine-disrupting chemicals (EDCs). However, to what extent these contaminants affect health is poorly known.We aimed to assess the association between EDCs exposure and asthma, respiratory symptoms and obesity in schoolchildren.Methods: Data from a cross-sectional analysis of 815 participants from 20 schools in Porto, Portugal, were analysed. Symptoms were assessed, asthma was defined on lung function, and airway reversibility and body mass index (BMI) were calculated.The concentrations of 13 volatile organic compounds and 2 aldehydes identified as EDCs were measured in 71 classrooms throughout 1 week. Principal component analysis (PCA) was used to assess the effect of co-exposure. Associations were estimated by regression coefficients using linear and logistic regression models.Results: Increased individual and combined EDCs levels were found in classrooms having more children with asthma and obesity. Higher levels of hexane, styrene, cyclohexanone, butylated hydroxytoluene and 2-butoxyethanol were associated with obesity, and higher levels of cyclohexanone were associated with increased child BMI. Toluene, oxylene, m/p-xylene and ethylbenzene were significantly associated with nasal obstruction.A positive association was found between PC1 and the risk of obese asthma (OR = 1.43, 95% CI 1.01, 1.98) and between PC2 and overweight (OR = 1.51, 95% CI 1.28, 1.79).PC1 and PC2 were also associated with nasal obstruction, and PC2 was associated with breathing difficulties and lean body mass, although EDCs concentrations were low. Conclusions:Our findings further support the role of EDCs in asthma and obesity development. Moreover, even low levels of indoor exposure may influence the risk of asthma, respiratory symptoms and obesity.

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Section: Discussionmentioning

confidence: 81%

Exposure to indoor endocrine‐disrupting chemicals and childhood asthma and obesity

Paciência

Rufo

Silva

et al. 2019

Allergy

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“…Thirteen studies assessed measures of oxidative stress biomarkers with MEP or MiBP. The biomarkers included malondialdehyde measured in urine (MDA; Kim et al 2014;Duan et al 2017), gamma glutamyltransferase measured in serum (GGT; Ferguson et al 2011), bilirubin measured in serum (Ferguson et al 2012), 8-hydroxydeoxyguanosine measured in urine (8-OHdG; Ferguson et al 2014;Guo et al 2014;Ferguson, McElrath, Chen, et al 2015;Franken et al 2017;Lin et al 2017;Rocha et al 2017), and 8-isoprostane measured in urine (Ferguson et al 2014;Ferguson, McElrath, Chen, et al 2015;Holland et al 2016;Lin et al 2017;Tran et al 2017;Wu et al 2017). One study measured MEP in relation to genetic single nucleotide polymorphisms (SNPs) of oxidative stressassociated genes (Wang and Karmaus 2017).…”

Section: Oxidative Stressmentioning

confidence: 99%

“…One study measured MEP in relation to genetic single nucleotide polymorphisms (SNPs) of oxidative stressassociated genes (Wang and Karmaus 2017). Five of the studies measured oxidative stress in populations of children (Kim et al 2014;Franken et al 2017;Rocha et al 2017;Tran et al 2017;Wang and Karmaus 2017) and six studies used adultonly populations (Ferguson et al 2014;Guo et al 2014;Ferguson, McElrath, Chen, et al 2015;Holland et al 2016;Duan et al 2017;Wu et al 2017). Three studies examined populations of both children and adults (Ferguson et al 2011;2012;Lin et al 2017).…”

Section: Oxidative Stressmentioning

confidence: 99%

“…The association between MiBP and 8-OHdG was consistent across different ages (both children and adults) and in populations from five different countries (U.S., Puerto Rico, Belgium, Taiwan, and Brazil). All six studies were cross-sectional, although two of the studies measured MiBP and 8-OHdG at multiple time points (Ferguson et al 2014;Ferguson, McElrath, Chen, et al 2015), two were low-quality correlation analyses (Guo et al 2014;Rocha et al 2017), and one used an undefined measure of effect (Franken et al 2017).…”

Section: Oxidative Stressmentioning

confidence: 99%

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Systematic review and quality ranking of studies of two phthalate metabolites and anogenital distance, bone health, inflammation, and oxidative stress

Sweeney¹,

O’Leary²,

Jeney³

et al. 2019

Critical Reviews in Toxicology

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Phthalates are ubiquitous chemical compounds, and two-di-ethyl phthalate (DEP) and di-isobutyl phthalate (DiBP)-are not currently regulated by the U.S. Congress or the European Union. While many reviews of phthalates have been published, none have examined bone health, inflammation, or oxidative stress; anogenital distance was most recently reviewed in 2014. The objective of this paper is to determine if an association exists between mono-ethyl phthalate (MEP) or mono-isobutyl phthalate (MiBP), metabolites of DEP and DiBP, respectively, and the four outcomes indicated above. We conducted a literature search of PubMed through December 2017 and included 29 observational epidemiologic studies published in English that assessed MEP and/or MiBP in relation to one of the above four health outcomes in humans. Two authors rated each paper using a modified Downs and Black (DB) assessment tool; a third author settled score disagreements. A single author extracted information related to the study population, exposure and outcome assessment, covariates, and significant results from each article. Ten studies were identified on anogenital distance, four on bone health, five on inflammation, and thirteen on oxidative stress. Score percentages (total points given out of total possible points) were calculated for each study. The current research suggests a positive association between MiBP and two measures of oxidative stress, 8-hydroxydeoxyguanosine (8-OHdG) and 8-isoprostane. MEP is potentially associated with 8-OHdG as well, although the evidence is limited by fewer highquality studies. There does not appear to be an association between anogenital distance and MEP or MiBP, and it is unclear if relationships exist between these phthalate metabolites and bone health and inflammation. Given the role that oxidative stress plays in a number of diseases and the ubiquity of MEP and MiBP, it is important that individuals be aware of potential sources of exposure to these chemicals.

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“…These include detergents, plasticizers, pharmaceuticals, pesticides, and other consumer products. These untested and unregulated chemicals have had unforeseen impacts on the ecosystem (Wang and Zhou, 2013) and human health (Franken et al, 2017). As they possess chemical structures similar to natural hormones (Diamanti-Kandarakis et al, 2009), EDs are able to bind and activate many receptors, including nuclear hormone receptors (Li et al, 2015, Zhang et al, 2017a, and disrupt the endocrine system .…”

Section: Introductionmentioning

confidence: 99%

Systems analysis of the liver transcriptome in adult male zebrafish exposed to the non-ionic surfactant nonylphenol

Huff

Silveira

Hazard

et al. 2019

General and Comparative Endocrinology

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Nonylphenol (NP) arises from the environmental degradation of nonylphenol ethoxylates. It is a ubiquitous environmental contaminant and has been detected at levels up to 167 nM in rivers in the United States. NP is an endocrine disruptor (ED) that can act as an agonist for estrogen receptors. The Adverse Outcome Pathway (AOP) framework defines an adverse outcome as the causal result of a series of molecular initiating events (MIEs) and key events (KEs) that lead to altered phenotypes. This study examined the liver transcriptome after a 21 day exposure to NP and 17β-estradiol (E2) by exploiting the zebrafish (Danio rerio) as a systems toxicology model. The goal of this study was to tease out non-estrogenic genomic signatures associated with NP exposure using DNA microarray and RNA sequencing. Our experimental design included E2 as a positive and potent estrogenic control in order to effectively compare and contrast the 2 compounds. This approach allowed us to identify hepatic transcriptomic perturbations that could serve as MIEs for adverse health outcomes in response to NP. Our results revealed that exposure to NP was associated with differential expression (DE) of genes associated with the development of steatosis, disruption of metabolism, altered immune response, and metabolism of reactive oxygen species, further highlighting NP as a chemical of emerging concern (CEC).

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Phthalate-induced oxidative stress and association with asthma-related airway inflammation in adolescents

Cited by 76 publications

References 72 publications

Exposure to indoor endocrine‐disrupting chemicals and childhood asthma and obesity

Exposure to indoor endocrine‐disrupting chemicals and childhood asthma and obesity

Systematic review and quality ranking of studies of two phthalate metabolites and anogenital distance, bone health, inflammation, and oxidative stress

Systems analysis of the liver transcriptome in adult male zebrafish exposed to the non-ionic surfactant nonylphenol

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