Phthalate exposure in pregnant women and newborns – The urinary metabolite excretion pattern differs distinctly

Enke, Uta; Schleußner, E; Pälmke, Claudia; Seyfarth, Lydia; Koch, Holger M.

doi:10.1016/j.ijheh.2013.01.006

Cited by 59 publications

(37 citation statements)

References 50 publications

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“…Since for DEHP it was possible to analyze primary metabolite (MEHP -the first step of DEHP metabolism pathway) and 2 secondary metabolites representing further steps of its metabolism (i.e., hydroxyl and oxo MEHP -the 2nd and the 3rd step), it was possible to identify the extent (progress) of DEHP metabolism. Thus, we calculated the ratio of the 2nd to the 1st step as 59.8 and the 3rd to the 2nd step as 5.7, which are much higher values than those calculated by Enke et al (2013) (2.4 and 0.9, respectively) [30]. The explanation of this observation is that the time period between exposure to phthalates and urine sampling for the analysis was longer in our study than in the study by Enke et al (2013) [30].…”

Section: Strengths and Limitationsmentioning

confidence: 54%

“…Thus, we calculated the ratio of the 2nd to the 1st step as 59.8 and the 3rd to the 2nd step as 5.7, which are much higher values than those calculated by Enke et al (2013) (2.4 and 0.9, respectively) [30]. The explanation of this observation is that the time period between exposure to phthalates and urine sampling for the analysis was longer in our study than in the study by Enke et al (2013) [30]. Nevertheless, we assessed the total daily intake of DEHP and DEP applying calculation…”

Section: Strengths and Limitationsmentioning

confidence: 54%

“…The existing studies provide the evidence that urinary biomarkers represent phthalate exposure from various products [1,21,30]. The analysis performed by Buckey et al (2013) indicated a higher level of mono-butyl phthalate (MBP) among pregnant women who used nail polish, MBzP among those who used eye makeup or used makeup on a regular basis, and DEHP metabolites among those who used cologne or perfume [21].…”

Section: Ijomeh 2016;29(4)mentioning

confidence: 99%

See 2 more Smart Citations

Effect of environmental phthalate exposure on pregnancy duration and birth outcomes

Polańska¹,

Ligocka²,

Sobala³

et al. 2016

Int J Occup Med Environ Health

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Objectives: The objective of this study was to evaluate the impact of phthalate exposure on pregnancy duration and birth outcomes based on the Polish Mother and Child Cohort (REPRO_PL). Material and Methods: Phthalate exposure was determined by measuring 11 phthalate metabolites (mono-ethyl phthalate (MEP), mono-iso-butyl phthalate (MiBP), mono-n-butyl phthalate (MnBP), 3OH-mono-n-butyl phthalate (OH-MnBP), mono-benzyl phthalate (MBzP), mono-(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-hydroxy-iso-nonyl phthalate (MHiNP), mono-oxo-iso-nonyl phthalate (MOiNP), and mono-n-octyl phthalate (MOP)) in the urine collected from 165 mothers during the third trimester of pregnancy by high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). The following measures at birth were considered: gestational age, birth weight, length as well as head and chest circumference. Results: Pregnancy duration was inversely associated with natural log concentrations (μg/g creatinine) of MEP (standardized regression coefficient (β) = -0.2, p = 0.04) after adjustment for a variety of confounders. Significant impact of MOiNP on head circumference (β = -0.1, p = 0.05) was also observed. Conclusions: The study findings add further support to the hypothesis that phthalate exposure may be associated with shorter pregnancy duration and a decreased head circumference, and underscore importance of public health interventions to reduce that exposure.

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Section: Strengths and Limitationsmentioning

confidence: 54%

Section: Strengths and Limitationsmentioning

confidence: 54%

Section: Ijomeh 2016;29(4)mentioning

confidence: 99%

See 1 more Smart Citation

Effect of environmental phthalate exposure on pregnancy duration and birth outcomes

Polańska¹,

Ligocka²,

Sobala³

et al. 2016

Int J Occup Med Environ Health

View full text Add to dashboard Cite

show abstract

“…Despite these concerns, data on phthalate exposure levels during this period of life are sparse (Adibi et al 2008; Enke et al 2013; Sathyanarayana et al 2008a, 2008b). Some studies have reported extremely high exposure to di(2-ethylhexyl) phthalate (DEHP) during hospitalization in preterm children (Silva et al 2006; Su et al 2012; Weuve et al 2006), suggesting a risk of adverse health effects in this group as gonadal development is not completed (Rey and Josso 2013) and detoxification processes are still immature (Coughtrie et al 1988; Tan et al 1990).…”

Section: Introductionmentioning

confidence: 99%

A Longitudinal Study of Urinary Phthalate Excretion in 58 Full-Term and 67 Preterm Infants from Birth through 14 Months

Frederiksen

Kuiri-Hänninen

Main

et al. 2014

Environ Health Perspect

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Background: Some phthalates have shown antiandrogenic effects in rat offspring. Premature infants may be exposed to high amounts of specific phthalates during hospitalization, and thus are potentially at risk.Objective: We evaluated longitudinal phthalate exposure and metabolism in full-term (FT) and preterm (PT) infants.Methods: Fifty-eight FT and 67 PT (gestational age, 24.7–36.6 weeks) infants were recruited at birth and followed until 14 months (nine times). Urinary concentrations of metabolites of diethyl phthalate (DEP), dibutyl phthalate isomers (DiBP and DnBP), butylbenzyl phthalate (BBzP), di(2-ethylhexyl) phthalate (DEHP), and diisononyl phthalate (DiNP) were measured in 894 samples. Daily intake and a hazard index for antiandrogenic effects were estimated, and excretion patterns of DEHP and DiNP metabolites were analyzed.Results: Metabolites of BBzP, DiNP, and DEHP were 5–50 times higher at day 7 (D7) and month 1 (M1) in PT than in FT infants. Thereafter, metabolite concentrations were similar between the two groups. The estimated hazard index for combined DiBP, DnBP, BBzP, and DEHP exposures 7 days after birth exceeded the antiandrogenic threshold in > 80% of PT and > 30% of FT infants, and after M2, in 30% of all infants. The excretion pattern of DEHP and DiNP metabolites changed with age.Conclusion: Most PT infants and approximately one-third of healthy FT newborns were exposed to phthalates during early life at a potentially harmful level according to the European Food Safety Authority’s recommended limits of daily exposure. Changes in the relative proportions of secondary phthalate metabolites over time were consistent with maturation of infant metabolic pathways during the first year of life. Further research is needed on the health effects of phthalate exposures and the influence of changes in metabolic capacity in neonates and infants.Citation: Frederiksen H, Kuiri-Hänninen T, Main KM, Dunkel L, Sankilampi U. 2014. A longitudinal study of urinary phthalate excretion in 58 full-term and 67 preterm infants from birth through 14 months. Environ Health Perspect 122:998–1005; http://dx.doi.org/10.1289/ehp.1307569

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“…Breastfed children also ingest phthalates with the mother's milk [32]. Phthalates were identified in urine samples from newborns, which indicates that the analyzed compounds easily cross the placental barrier and pose a threat to unborn children [33]. The available reference literature contains relatively few publications dealing with this problem.…”

Section: The Influence Of Phthalates On Humansmentioning

confidence: 99%

Environmental contamination with phthalates and its impact on living organisms

Przybylińska

Wyszkowski

2016

Ecological Chemistry and Engineering S

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Abstract:The relevant literature was reviewed to identify phthalate sources in the environment and problems resulting from phthalate contamination of soil and water. Phthalate properties responsible for their toxicity for living organisms were identified, and the effects of phthalates on humans and animals were described. Special emphasis was placed on the effects of exposure to phthalates on human health. Phthalates are readily released into the environment and create a risk of exposure for humans and other living organisms. They are characterized by reproductive toxicity in humans and animals, they can cause infertility and reproductive problems in males. Phthalates are more toxic in young children, which are much more susceptible to phthalate exposure, including fetal life. Phthalates are used in numerous industries, and they are very difficult to eliminate from our daily surroundings.

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Phthalate exposure in pregnant women and newborns – The urinary metabolite excretion pattern differs distinctly

Cited by 59 publications

References 50 publications

Effect of environmental phthalate exposure on pregnancy duration and birth outcomes

Effect of environmental phthalate exposure on pregnancy duration and birth outcomes

A Longitudinal Study of Urinary Phthalate Excretion in 58 Full-Term and 67 Preterm Infants from Birth through 14 Months

Environmental contamination with phthalates and its impact on living organisms

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