Effect of environmental phthalate exposure on pregnancy duration and birth outcomes

Polańska, Kinga; Ligocka, Danuta; Sobala, Wojciech; Hanke, Wojciech

doi:10.13075/ijomeh.1896.00691

Cited by 52 publications

(31 citation statements)

References 45 publications

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“…In another study of 68 women from Michigan, Watkins and colleagues (2016) observed an inverse relationship between the sum of DBP metabolites (MBP, MHBP, MCPP) at delivery and gestational age [ 38 ]. Polanska and colleagues (2016) observed significant inverse associations between maternal MEP in the third trimester and gestational age from a prospective birth cohort in Poland ( N = 165) [ 36 ]. In a cohort of strictly African American and Dominican women in New York ( N = 331), Whyatt and colleagues (2009) found that shorter gestational duration was significantly associated with higher maternal urinary concentrations of MEHP, MEHHP, MEOHP, and MECPP in the third trimester [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Associations between mixtures of urinary phthalate metabolites with gestational age at delivery: a time to event analysis using summative phthalate risk scores

et al. 2018

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BackgroundPreterm birth is a significant public health concern and exposure to phthalates has been shown to be associated with an increased odds of preterm birth. Even modest reductions in gestational age at delivery could entail morbid consequences for the neonate and analyzing data with this additional information may be useful. In the present analysis, we consider gestational age at delivery as our outcome of interest and examine associations with multiple phthalates.MethodsWomen were recruited early in pregnancy as part of a prospective, longitudinal birth cohort at the Brigham and Women’s Hospital in Boston, Massachusetts. Urine samples were collected at up to four time points during gestation for urinary phthalate metabolite measurement, and birth outcomes were recorded at delivery. From this population, we selected all 130 cases of preterm birth (< 37 weeks of gestation) as well as 352 random controls. We conducted analysis with both geometric average of the exposure concentrations across the first three visits as well as using repeated measures of the exposure. Two different time to event models were used to examine associations between nine urinary phthalate metabolite concentrations and time to delivery. Two different approaches to constructing a summative phthalate risk score were also considered.ResultsThe single-pollutant analysis using a Cox proportional hazards model showed the strongest association with a hazard ratio (HR) of 1.21 (95% confidence interval (CI): 1.09, 1.33) per interquartile range (IQR) change in average log-transformed mono-2-ethyl-5-carboxypentyl phthalate (MECPP) concentration. Using the accelerated failure time model, we observed a 1.19% (95% CI: 0.26, 2.11%) decrease in gestational age in association with an IQR change in average log-transformed MECPP. We next examined associations with an environmental risk score (ERS). The fourth quartile of ERS was significantly associated with a HR of 1.44 (95% CI: 1.19, 1.75) and a reduction of 2.55% (95% CI: 0.76, 4.30%) in time to delivery (in days) compared to the first quartile.ConclusionsOn average, pregnant women with higher urinary metabolite concentrations of individual phthalates have shorter time to delivery. The strength of the observed associations are amplified with the risk scores when compared to individual pollutants.Electronic supplementary materialThe online version of this article (10.1186/s12940-018-0400-3) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Associations between mixtures of urinary phthalate metabolites with gestational age at delivery: a time to event analysis using summative phthalate risk scores

et al. 2018

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“…While in an Italian study, and association was found between MEHP and the shorter mean gestational age (8.4 days) alone (68). Aside from measuring phthalate metabolites in cord blood, most researches (69,84,85) focused on assessing phthalate exposure via maternal urine. After adjustment for possible confounders, a negative association between the pregnancy duration and maternal urinary MEP in the third trimester was observed in a prospective cohort from Poland (n = 165), which was of borderline significance (84).…”

Section: Prenatal Phthalate Exposure and Gestational Agementioning

confidence: 99%

The Endocrine Disruption of Prenatal Phthalate Exposure in Mother and Offspring

Qian

Shao

Ying

et al. 2020

Front. Public Health

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Phthalates are a group of ubiquitous synthetic endocrine-disrupting chemicals. Fetal and neonatal periods are particularly susceptible to endocrine disorders, which prenatal exposure to phthalates causes. There is increasing evidence concerning the potential endocrine disrupting for phthalate exposure during pregnancy. This article aims to review the endocrine impairment and potential outcomes of prenatal phthalate exposure. Prenatal exposure phthalates would disrupt the levels of thyroid, sex hormone, and 25-hydroxyvitamin D in pregnant women or offspring, which results in preterm birth, preeclampsia, maternal glucose disorders, infant cryptorchidism, infant hypospadias, and shorter anogenital distance in newborns, as well as growth restriction not only in infants but also in early adolescence and childhood. The relationship of prenatal phthalate exposure with maternal and neonatal outcomes in human beings was often sex-specific associations. Because of the potentially harmful influence of prenatal phthalate exposure, steps should be taken to prevent or reduce phthalate exposure during pregnancy.

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“…Somewhat surprisingly, we found that phthalate polymers from drugs appear to have similar effects. Some studies have addressed the potential association between environmental phthalate exposure (assessed by biomarkers) and PTB or differences in gestational age 3,[25][26][27][28][29][30][31][32] . Studies that focus on gestational age are less conclusive, whereas studies that address the risk of PTB, support an association.…”

Section: Commentmentioning

confidence: 99%

Phthalate exposure from drugs during pregnancy and possible risk of preterm birth and small for gestational age

Broe

Pottegård

Hallas

et al. 2019

European Journal of Obstetrics & Gynecology and Reproductiv

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Effect of environmental phthalate exposure on pregnancy duration and birth outcomes

Cited by 52 publications

References 45 publications

Associations between mixtures of urinary phthalate metabolites with gestational age at delivery: a time to event analysis using summative phthalate risk scores

Associations between mixtures of urinary phthalate metabolites with gestational age at delivery: a time to event analysis using summative phthalate risk scores

The Endocrine Disruption of Prenatal Phthalate Exposure in Mother and Offspring

Phthalate exposure from drugs during pregnancy and possible risk of preterm birth and small for gestational age

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