Phthalate exposure and child development: The Polish Mother and Child Cohort Study

Polańska, Kinga; Ligocka, Danuta; Sobala, Wojciech; Hanke, Wojciech

doi:10.1016/j.earlhumdev.2014.06.006

Cited by 110 publications

(99 citation statements)

References 38 publications

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“…Except for correlations between MEP and MBzP or DiNP or MOP, and between DiNP and MiBP or DEHP or MOP, all the other phthalates were significantly correlated with each other (with correlation coefficients ranging from r = 0.2, p < 0.05 to r = 0.7, p < 0.01) (details included in a previous publication [23]). …”

Section: Exposure Assessmentmentioning

confidence: 99%

“…The details regarding chemical analysis have been previously published [23]. Briefly, urinary phthalate metabolites were determined using the liquid chromatography coupled with tandem mass spectrometry with negative electrospray ionisation (Waters QuattroMicro API tandem mass spectrometer, Waters, USA), in a concentration range of 0.4-500 μg/l.…”

Section: Analytical Protocolmentioning

confidence: 99%

See 1 more Smart Citation

Effect of environmental phthalate exposure on pregnancy duration and birth outcomes

Polańska¹,

Ligocka²,

Sobala³

et al. 2016

Int J Occup Med Environ Health

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Objectives: The objective of this study was to evaluate the impact of phthalate exposure on pregnancy duration and birth outcomes based on the Polish Mother and Child Cohort (REPRO_PL). Material and Methods: Phthalate exposure was determined by measuring 11 phthalate metabolites (mono-ethyl phthalate (MEP), mono-iso-butyl phthalate (MiBP), mono-n-butyl phthalate (MnBP), 3OH-mono-n-butyl phthalate (OH-MnBP), mono-benzyl phthalate (MBzP), mono-(2-ethylhexyl) phthalate (MEHP), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP), mono-hydroxy-iso-nonyl phthalate (MHiNP), mono-oxo-iso-nonyl phthalate (MOiNP), and mono-n-octyl phthalate (MOP)) in the urine collected from 165 mothers during the third trimester of pregnancy by high performance liquid chromatography with tandem mass spectrometry (HPLC-MS/MS). The following measures at birth were considered: gestational age, birth weight, length as well as head and chest circumference. Results: Pregnancy duration was inversely associated with natural log concentrations (μg/g creatinine) of MEP (standardized regression coefficient (β) = -0.2, p = 0.04) after adjustment for a variety of confounders. Significant impact of MOiNP on head circumference (β = -0.1, p = 0.05) was also observed. Conclusions: The study findings add further support to the hypothesis that phthalate exposure may be associated with shorter pregnancy duration and a decreased head circumference, and underscore importance of public health interventions to reduce that exposure.

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Section: Exposure Assessmentmentioning

confidence: 99%

Section: Analytical Protocolmentioning

confidence: 99%

Effect of environmental phthalate exposure on pregnancy duration and birth outcomes

Polańska¹,

Ligocka²,

Sobala³

et al. 2016

Int J Occup Med Environ Health

Self Cite

View full text Add to dashboard Cite

show abstract

“…For instance, the Health Outcomes and Measures of the Environment study (HOME) in the United States (Yolton et al, 2011), the Polish Mother and Child Cohort study (REPRO_PL) in Poland (Polanska et al, 2014), the Mothers and Children's Environmental Health study (MOCEH) in Korea (Kim et al, 2011), the Early Life Exposure in Mexico to Environmental Toxicants cohort study (ELEMENT) (Téllez-Rojo et al, 2013), and the Taiwan Maternal and Infant Cohort study (Lien et al, 2015) have analyzed urinary concentrations of several phthalate metabolites in pregnant women. In the mainland of China, limited studies have investigated urinary phthalate levels in this population.…”

Section: Introductionmentioning

confidence: 99%

Season-dependent concentrations of urinary phthalate metabolites among Chinese pregnant women: Repeated measures analysis

Gao

Zhu

et al. 2017

Environment International

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“…Phthalates, one class of EDCs, are used in a large variety of commercial products, such as medical products, food packaging, personal care products and solvents (Jurewicz and Hanke, 2011). Because they are not chemically bound to products, phthalates are easily released into the environment resulting in chronic and widespread human exposure in the USA (CDC, 2015) and globally (Ha et al, 2014;Polanska et al, 2014, Sakhi et al, 2014Bai et al, 2015). The potential of phthalates to adversely influence reproductive health has been well documented (Mariana et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Parental contributions to early embryo development: influences of urinary phthalate and phthalate alternatives among couples undergoing IVF treatment

Ashcraft

Whitcomb

et al. 2016

Hum. Reprod.

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STUDY QUESTION: Are preconception urinary concentrations of phthalates and phthalate alternatives associated with diminished early stage embryo quality in couples undergoing IVF?SUMMARY ANSWER: Male, but not female, urinary concentrations of select metabolites of phthalates and phthalate alternatives are associated with diminished blastocyst quality.WHAT IS KNOWN ALREADY: Although phthalates are endocrine disrupting compounds associated with adverse reproductive health, they are in widespread use across the world. Male and female preconception exposures to select phthalates have been previously associated with adverse reproductive outcomes in both the general population and in those undergoing IVF. STUDY DESIGN, SIZE, DURATION: This prospective cohort included 50 subfertile couples undergoing IVF in western Massachusetts. PARTICIPANTS/MATERIALS, SETTING, METHODS:This study includes the first 50 couples recruited from the Baystate Medical Center's Fertility Center in Springfield, MA, as part of the Sperm Environmental Epigenetics and Development Study (SEEDS). Relevant data from both partners, including embryo quality at the cleavage (Day 3) and blastocyst (Day 5) stages, were collected by clinic personnel during the normal course of an IVF cycle. A spot urine sample was collected from both male and female partners on the same day as semen sample procurement and oocyte retrieval. Concentrations of 17 urinary metabolite were quantified by liquid chromatography mass spectrometry and normalized via specific gravity. Generalized estimating equations were used to estimate odds ratios (OR) and 95% CI, with urinary phthalates and phthalate alternatives fitted as continuous variables and embryo quality as a binary variable. MAIN RESULTS AND THE ROLE OF CHANCE:The 50 couples contributed 761 oocytes, of which 423 progressed to the cleavage stage, 261 were high-quality cleavage stage embryos, 137 were transferrable quality blastocysts and 47 were high-quality blastocysts. At the cleavage stage, male urinary monoethyl phthalate concentrations were positively associated with high-quality cleavage stage embryos (OR = 1.20, 95% CI 1.01-1.43, P = 0.04); no other significant associations were observed at this stage. At the blastocyst stage, male urinary concentrations of monobenzyl phthalate (OR = 0.55, 95% CI 0.36-0.84, P = 0.01), mono-3-hydroxybutyl phthalate (OR = 0.37, 95% CI 0.18-0.76, P = 0.01), mono-n-butyl phthalate (OR = 0.55, 95% CI 0.42-0.73, P < 0.01) and monomethyl phthalate (OR = 0.39, 95% CI 0.26-0.60, P < 0.01) were inversely associated with high-quality blastocysts. A borderline statistically significant relationship was observed for male concentrations of mono (2-ethylhexyl) phthalate (OR = 0.52, 95% CI 0.27-1.00, P = 0.05) and cyclohexane-1,2-dicarboxylic acid-monocarboxy isooctyl ester (OR = 0.21, 95% CI 0.04-1.03, P = 0.05) at the blastocyst stage. Similar inverse associations were observed between male urinary phthalate metabolite concentrations and likelihood of transferrable quality blastocysts. For femal...

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Phthalate exposure and child development: The Polish Mother and Child Cohort Study

Cited by 110 publications

References 38 publications

Effect of environmental phthalate exposure on pregnancy duration and birth outcomes

Effect of environmental phthalate exposure on pregnancy duration and birth outcomes

Season-dependent concentrations of urinary phthalate metabolites among Chinese pregnant women: Repeated measures analysis

Parental contributions to early embryo development: influences of urinary phthalate and phthalate alternatives among couples undergoing IVF treatment

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