Photovoltaic polymer Photosensitizer-Doped Nano-Therapeutic reagent for in vivo enhanced bioimaging guided photodynamic therapy

Zhao, Tingting; Hu, Xinlong; Ma, Ruijie; Dong, Fengqi; Liu, Tao; Li, Lü; Yan, He; Xu, Yanli; Liu, Wei; Zou, B. S.; Tang, Bo

doi:10.1016/j.cej.2022.135983

Cited by 11 publications

(8 citation statements)

References 56 publications

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Section: Cancer Therapymentioning

confidence: 99%

“…In order to solve the problem of realizing both high fluorescence efficiency and singlet oxygen generation efficiency under visible light excitation, Tang et al broke the performance bottleneck by cleverly combining the novel polymer (J71, CP32, Scheme 4) with a hydrophobic CP to design an effective donor recipient system with excellent imaging and PDT capabilities (Figure 14g). 150 Compared with traditional porphyrins, J71 has better photostability. Through fluorescence resonance energy transfer from CP to J71, the Φ SO and Φ f values of the NPs can be increased to 0.704 and 0.255, respectively.…”

Section: Other Conjugated Polymers As Pss For Pdtmentioning

confidence: 99%

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Conjugated Polymer Nanoparticles for Tumor Theranostics

Wei

et al. 2023

Biomacromolecules

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Water-dispersible conjugated polymer nanoparticles (CPNs) have demonstrated great capabilities in biological applications, such as in vitro cell/subcellular imaging and biosensing, or in vivo tissue imaging and disease treatment. In this review, we summarized the recent advances of CPNs used for tumor imaging and treatment during the past five years. CPNs with different structures, which have been applied to in vivo solid tumor imaging (fluorescence, photoacoustic, and dual-modal) and treatment (phototherapy, drug carriers, and synergistic therapy), are discussed in detail. We also demonstrated the potential of CPNs as cancer theranostic nanoplatforms. Finally, we discussed current challenges and outlooks in this field.

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Section: Cancer Therapymentioning

confidence: 99%

Section: Other Conjugated Polymers As Pss For Pdtmentioning

confidence: 99%

Conjugated Polymer Nanoparticles for Tumor Theranostics

Wei

et al. 2023

Biomacromolecules

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“…Then, ABDA was also used as a probe to real-time monitor the 1 O 2 generation by M1. As shown in Figure 3a, because of the photo-oxidation of ABDA induced by 1 O 2 generation, 65,66 the absorption peaks at 378 and 400 nm corresponding to ABDA exhibited a time-dependent decrease in the time range from 0 to 10 min when it was incubated with M1 and exposed to laser irradiation. Under the same condition, two control groups, ABDA&M1 (laser off) and pure ABDA (laser on), were also measured to simultaneously evaluate the photo-oxidation of ABDA by different samples.…”

Section: Table 1 Molecular Parameters Of Corresponding Stimuli-respon...mentioning

confidence: 99%

Deformable and Disintegrable Multifunctional Integrated Polyprodrug Amphiphiles for Synergistic Phototherapy and Chemotherapy

et al. 2022

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Multimodal collaborative therapy has been recognized as one of the more effective means to eliminate tumors in the current biomedicine research field as compared with monotherapy. Among them, by taking advantage of its high-precision and controllability, phototherapy has become a mainstay of treatment. However, physical encapsulation of free photosensitive units within nanocarriers was one of the main implementations, which might inevitably result in the photosensitizer leakage and side effect. For this purpose, a kind of multifunctional integrated polyprodrug amphiphiles, P(PFO-IG-CPT)-PEG, were prepared by reversible addition–fragmentation chain transfer polymerization from polymerizable pentadecafluorooctan monomers, indocyanine green monomers, reduction-responsive camptothecin monomers, and acid-responsive PEG based methacrylate monomers (GMA(-OH/-PEG)). The resultant copolymers could self-assemble into spherical nanoparticles in water, performing size-deformability in acidic conditions and subsequent disintegration in reduction environment as demonstrated by in vitro experiments. Furthermore, an enhanced CPT release ratio and rate from nanoparticles could be achieved by a NIR irradiation due to the hyperthermia induced by the covalently linked IG moieties. Not only that, because of the sufficient O2 content brought by PFO, the NIR light-triggered generation of 1O2 was also detected in cells. With the combination of CPT-guided chemotherapy as well as NIR light-guided photo-thermal and photodynamic therapies, fatal and irreversible damage to cancer cells was observed by cell experiments; the implanted tumor size in the mouse model was obviously shrunk upon receiving multimodal collaborative therapy. We speculate that such fabricated nanodiagnosis and treatment systems could meet the growing emergency for effective drug delivery, programmed and on-demand drug release, and multimodal integrated therapy.

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“…[6][7][8][9] Photodynamic therapy (PDT) has been widely studied in recent years as a novel cancer treatment with the advantages of non-invasiveness, high selectivity, excellent repeatability and low systemic cytotoxicity. [10][11][12][13][14] PDT is the production of cytotoxic reactive oxygen species (ROS) after light activation of nontoxic photosensitizers (PSs) in the tumor area, which has the ability to kill the tumor. Photosensitizer (PS) plays a major role in the process of PDT.…”

Section: Introductionmentioning

confidence: 99%