Photothermal Therapy with Ag Nanoparticles in Mesoporous Polydopamine for Enhanced Antibacterial Activity

Abstract

Photothermal therapy (PTT) is a promising method to kill pathogenic bacteria. However, using single-modal PTT, it is easy to cause tissue damage because of the overtemperature. Hence, it is necessary to combine PTT with other antibacterial strategies. In this study, we employed silver nanoparticles (Ag NPs) and mesoporous polydopamine (MPDA) nanoparticles to establish a multimodal antibacterial platform (MPDA@Ag). MPDA nanoparticles not only served as a photothermal transduction agent to convert light-energy to heat under the irradiation of near-infrared (NIR) light but also acted as a reducer to reduce Ag NPs in situ. Because Ag NPs can effectively kill bacteria, MPDA@Ag can overcome the drawbacks of the single-modal PTT antibacterial strategy, achieving a synergistic antibacterial effect. Moreover, as an antibiotic-free strategy, MPDA@Ag was less likely to induce drug resistance when killing bacteria. In summary, this platform offered a simple and practical means to achieve excellent antibacterial activity and supplied a good alternative to fight pathogenic bacteria.

Vancomycin-Loaded Porphyrinic MOF Nanoparticles for Killing Pathogenic Bacteria

“…The reduction rate significantly ( p < 0.01) ascended in the Van/PCN+L group, meaning that Van/PCN+L had the best inhibitory effect on the generation of extracellular polysaccharides. Previous studies have reported that extracellular polysaccharides were vital for forming the 3D structure of bacterial biofilm, for polysaccharides served as essential scaffold and mediated microcolony formation in biofilm. , Therefore, the reduction effect of Van/PCN+L on extracellular polysaccharides suggested that the antibacterial nanoplatform possessed the ability to destruct biofilm.…”

“…Previous studies have reported that extracellular polysaccharides were vital for forming the 3D structure of bacterial biofilm, 46 for polysaccharides served as essential scaffold and mediated microcolony formation in biofilm. 47,48 Therefore, the reduction effect of Van/PCN+L on extracellular polysaccharides suggested that the antibacterial nanoplatform possessed the ability to destruct biofilm. In addition, CLSM was introduced to investigate the influence of Van/PCN on S. aureus biofilm.…”

Functionalized Mesoporous Polydopamine Nanocarrier with Near-Infrared Laser-Trigged NO Release and Photothermal Effects for the Killing of Pathogenic Bacteria

“…After treatments, the obtained bacterial suspensions were centrifuged, washed, fixed, and dehydrated in sequence according to the method described in the literature. 45 Finally, we used SEM to observe the change in bacterial morphology.…”

AgCu Nanoparticles as an Antibacterial Coating for Wood

“…Thus, inorganic materials have gradually become the majority of the antibacterial additives in wood coatings . Nano silver (nano Ag) and nano copper (nano Cu) are the typical antibacterial agents and are widely used in the wood antibacterial domain, by combining with the virtues of inorganic materials and nanomaterials. , The antibacterial activity is attributed to the interaction of nanoparticles and released ions with bacterial cells. In-situ growth of silver particles on the wood surface by the silver mirror reaction could endow the antimicrobial rate of 99.9% .…”