Photothermal spectroscopy with femtojoule sensitivity using a micromechanical device

Barnes, J. R.; Stephenson, R. J.; Welland, Mark E.; Gerber, Ch.; Gimzewski, J. K.

doi:10.1038/372079a0

Cited by 327 publications

(199 citation statements)

References 9 publications

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“…The use of micro-mechanical sensors (MEMS) has increased dramatically over the last fifteen years, becoming a vital tool in fields such as diagnostics, photothermal spectroscopy, and mass and chemical detection; they are also at the heart of scanning probe microscopy, such as the atomic force microscope (AFM) [1][2][3][4][5] . AFMs have been used extensively to map sample topography to nanometre resolution, and new techniques are extending their operating potential beyond topography to include measurements of properties such as the hardness, viscoelasticity and stiffness of a sample 6,7 .…”

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confidence: 99%

A calibration method for the higher modes of a micro-mechanical cantilever

Shatil

Homer

Picco

et al. 2017

Applied Physics Letters

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General rightsThis document is made available in accordance with publisher policies. Please cite only the published version using the reference above. Full terms of use are available: http://www.bristol.ac.uk/pure/about/ebr-terms A Calibration Method for the Higher Modes of a Micro-mechanical Cantilever Micro-mechanical cantilevers are increasingly being used as a characterisation tool in both material and biological sciences. New non-destructive applications are being developed that rely on the information encoded within the cantilever's higher oscillatory modes, such as AFM techniques that measure non-topographic properties of a sample. However, these methods require the spring constants of the cantilever at higher modes to be known in order to quantify their results. Here, we show how to calibrate the micro-mechanical cantilever and find the effective spring constant of any mode. The method is uncomplicated to implement, using only properties of the cantilever and the fundamental mode that are straightforward to measure.

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confidence: 99%

A calibration method for the higher modes of a micro-mechanical cantilever

Shatil

Homer

Picco

et al. 2017

Applied Physics Letters

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“…Using this approach and a modified AFM instrument, researchers could detect enthalpy changes associated with phase transitions in nanogramsize samples. Alternatively, light-adsorbing samples in the form of thin (~100-nm) coatings were detected on cantilevers in a calorimetric spectroscopy mode (3).…”

Section: Applicationsmentioning

confidence: 99%

“…However, in 1994, two research teams, one from Oak Ridge National Laboratory and the other from IBM Zurich, converted the same mechanisms that caused the unwanted interference into a platform for a new family of sensors (2,3). They found that a standard AFM cantilever could function as a microcalorimeter, offering femtojoule sensitivity and a substantial improvement over more traditional approaches.…”

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Peer Reviewed: Microcantilever Transducers: A new Approach in Sensor Technology

Sepaniak

Datskos²,

Lavrik³

et al. 2002

Anal. Chem.

182

125

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“…According to measurement scheme, sensing mechanism of the micromechanical cantilevers can be categorized into static and dynamic detecting methods. With the static detecting method, the target molecules are detected by measuring cantilever surface stress, which is induced by specific bio/chemical binding or interaction at the surface of the cantilever [2][3][4][5][6]. Differently, the dynamic detecting method employs the cantilever as a resonator.…”

Section: Introductionmentioning

confidence: 99%

Integrated MEMS/NEMS Resonant Cantilevers for Ultrasensitive Biological Detection

Gan

et al. 2009

Journal of Sensors

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Recommended by Michele PenzaThe paper reviews the recent researches implemented in Chinese Academy of Sciences, with achievements on integrated resonant microcantilever sensors. In the resonant cantilevers, the self-sensing elements and resonance exciting elements are both topdown integrated with silicon micromachining techniques. Quite a lot of effort is focused on optimization of the resonance mode and sensing structure for improvement of sensitivity. On the other hand, to enable the micro-cantilevers specifically sensitive to bio/chemical molecules, sensing materials are developed and modified on the cantilever surface with a self-assembled monolayer (SAM) based bottom-up construction and surface functionalization. To improve the selectivity of the sensors and depress environmental noise, multiple and localized surface modifications are developed. The achieved volume production capability and satisfactory detecting resolution to trace-level biological antigen of alpha-fetoprotein (AFP) give the micro-cantilever sensors a great promise for rapid and high-resoluble detection.

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Photothermal spectroscopy with femtojoule sensitivity using a micromechanical device

Cited by 327 publications

References 9 publications

A calibration method for the higher modes of a micro-mechanical cantilever

A calibration method for the higher modes of a micro-mechanical cantilever

Peer Reviewed: Microcantilever Transducers: A new Approach in Sensor Technology

Integrated MEMS/NEMS Resonant Cantilevers for Ultrasensitive Biological Detection

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