Photothermal-enhanced antibacterial and antioxidant hydrogel dressings based on catechol-modified chitosan-derived carbonized polymer dots for effective treatment of wound infections

Abstract

Bacterial infection and excess reactive oxygen species (ROS) remain challenging factors contributing for the delayed healing of chronic wounds. Although various antibacterial and antioxidant hydrogel dressings have been developed to...

Antibacterial and antibiofilm mechanisms of carbon dots: a review

“…Our group prepared carbonized polymeric dots (CPDs) 70 with photothermal enhanced antibacterial effects by using catechol-modified chitosan polymer as the precursor (Fig. 5).…”

“…The authors investigated the binding interactions of CDs on DNA and RNA in bacteria by dynamic light scattering (DLS), circular dichroism spectroscopy and gel electrophoresis. The results showed that CDs can bind 70 to DNA and RNA and fungi through non-covalent bonds, change the secondary structure of DNA and RNA, and then affect the genetic processes of bacteria and fungi, ultimately killing them. Hao et al prepared PC-CQDs that were able to disrupt the membrane structure of bacteria by physical action and cause cytoplasmic exocytosis.…”

Photothermal Hydrogels for Promoting Infected Wound Healing

“…In addition, PVA@CPD hydrogels can act as effective antioxidants to scavenge free radicals while possessing broad-spectrum and rapid bactericidal activity. [106] In addition, by compounding with other hydrogel matrices, PVA-based hydrogels can be endowed with hemostatic, anti-inflammatory, antibacterial, or other functions that are beneficial to wound healing. Qing et al designed a multifunctional hydrogel with synergistic photothermal antibacterial activity and enhanced bone regeneration by adding MgO NPs and BP NSs to a PVA/CS matrix.…”

Antibacterial Carbon Dots: Mechanisms, Design, and Applications

“…Nano-materials such as silver nanoparticles (NPs), zinc oxide (ZnO) NPs, titanium dioxide NPs, antimicrobial peptides, aggregation-induced emission materials, graphene oxide, carbon nanotube, polymer NPs, carbon dots (CDs), and some carbonized nanomaterials offer a multitude of opportunities to inhibit or kill pathogenic microorganisms. [12,[16][17][18][19][20][21][22][23][24][25][26][27] Among them, as a zerodimensional carbon material consisting of a conjugated core and surface functional groups, CDs have attracted extensive interest due to their outstanding features. Since discovered in 2004, [32] Copyright 2021, Elsevier.…”