Photothermal Hydrogels for Promoting Infected Wound Healing

Xie, Ge; Wang, Xiao; Mo, Min; Zhang, Lianbin; Zhu, Jintao

doi:10.1002/mabi.202200378

Cited by 17 publications

(10 citation statements)

References 217 publications

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“…92 The ability of PTT to appropriately raise the temperature increases the permeability of the cell membrane by enzyme denaturation and damages the cell membrane proteins and phospholipids, making bacteria more susceptible to ROS damage and enhancing antibacterial efficacy. 111 However, there are still concerns surrounding the complexity of developing dual systems, their safety, and laser exposure duration. Numerous initiatives are still in the exploration stage, and difficulties must be overcome.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…The synergistic antibacterial method of PDT/PTT has a greater potential to eradicate bacteria than PTT and PDT alone, due to the PTT process’ ability to increase temperature appropriately, thereby increasing the permeability of the cell membrane by enzyme denaturation and damaging the protein and phospholipids on the cell membrane, making bacteria more susceptible to ROS damage and achieving significantly improved antibacterial efficacy . However, the design of such dual-mode antimicrobial agents has obstacles, such as the necessity to combine multiple compounds, which results in complex synthesis processes and biocompatibility concerns. , The intricate interplay between various components within hybrid materials may pose challenges in achieving optimal synergistic effects.…”

Section: Light-activated Antimicrobial Nanoparticle–polymer Compositesmentioning

confidence: 99%

“…Another important strategy is the development of dual-model light-assisted (PDT/PTT) antibacterial therapies, which are more effective at eliminating bacteria than PTT and PDT alone . The ability of PTT to appropriately raise the temperature increases the permeability of the cell membrane by enzyme denaturation and damages the cell membrane proteins and phospholipids, making bacteria more susceptible to ROS damage and enhancing antibacterial efficacy . However, there are still concerns surrounding the complexity of developing dual systems, their safety, and laser exposure duration.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

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Review of Light-Activated Antimicrobial Nanoparticle–Polymer Composites for Biomedical Devices

Omidiyan,

Srinoi,

Tajalli

et al. 2024

ACS Appl. Nano Mater.

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Nosocomial infections are a significant threat to public health that leads to substantial morbidity and mortality. The emergence and spread of antibiotic-resistant organisms have compounded the complexity of managing these infections, highlighting the urgent need for innovative and effective strategies to combat them. Photostimuli-responsive nanomaterials have emerged as promising tools for coating biomedical devices and tools against nosocomial infections due to their ability to selectively target and kill pathogenic bacteria and fungi. It is feasible to develop antibacterial surfaces by integrating photothermal agents (PTAs), photodynamic agents (PDAs), and both PTAs and PDAs into coatings. When exposed to light, PTAs generate heat that can be used to kill bacteria, while PDAs emit reactive oxygen species (ROS) that can also be used to kill bacteria. The combination of photothermal and photodynamic therapies produces a synergistic effect in which the death of bacteria is boosted in comparison with the use of each individual therapy. These coatings have the potential to provide enhanced bacterial control for a number of biomedical devices, including implants, catheters, meshes, and wound dressings. The utilization of antimicrobial nanomaterials offers a promising approach for reducing the risk of infections associated with the use of these devices.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Section: Light-activated Antimicrobial Nanoparticle–polymer Compositesmentioning

confidence: 99%

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

See 1 more Smart Citation

Review of Light-Activated Antimicrobial Nanoparticle–Polymer Composites for Biomedical Devices

Omidiyan,

Srinoi,

Tajalli

et al. 2024

ACS Appl. Nano Mater.

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“…Even worse, wound healing will be seriously interfered by infection when microbes invade these tissues. [ 198 ] The healing of a wound requires multiple factors to work concertedly. Treatments of wound dressings may break possible barriers to wound healing, ranging from infection to hypoxia.…”

Section: Biomedical Applications Of Photo‐thermo Coupled Responsive H...mentioning

confidence: 99%

Thermo‐Responsive Hydrogels Coupled with Photothermal Agents for Biomedical Applications

Qian

Meng

et al. 2023

Macromolecular Bioscience

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Intelligent hydrogels are materials with abilities to change their chemical nature or physical structure in response to external stimuli showing promising potential in multitudinous applications. Especially, photo‐thermo coupled responsive hydrogels that are prepared by encapsulating photothermal agents into thermo‐responsive hydrogel matrix exhibit more attractive advantages in biomedical applications owing to their spatiotemporal control and precise therapy. This work summarizes the latest progress of the photo‐thermo coupled responsive hydrogel in biomedical applications. Three major elements of the photo‐thermo coupled responsive hydrogel, i.e., thermo‐responsive hydrogel matrix, photothermal agents, and construction methods are introduced. Furthermore, the recent developments of these hydrogels for biomedical applications are described with some selected examples. Finally, the challenges and future perspectives for photo‐thermo coupled responsive hydrogels are outlined.This article is protected by copyright. All rights reserved

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“…12 Moreover, PDA possesses multiple functionalities, including drug-carrying and adhesion capabilities. 9 Therefore, dopaminecoated CuO NPs provide a feasible approach for the development of a biosafe and effective PTA.…”

Section: Introductionmentioning

confidence: 99%

Bletilla striata Polysaccharide-/Chitosan-Based Self-Healing Hydrogel with Enhanced Photothermal Effect for Rapid Healing of Diabetic Infected Wounds via the Regulation of Microenvironment

Zhao,

Hu,

Chen

et al. 2024

Biomacromolecules

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The management of diabetic ulcers poses a significant challenge worldwide, and persistent hyperglycemia makes patients susceptible to bacterial infections. Unfortunately, the overuse of antibiotics may lead to drug resistance and prolonged infections, contributing to chronic inflammation and hindering the healing process. To address these issues, a photothermal therapy technique was incorporated in the preparation of wound dressings. This innovative solution involved the formulation of a self-healing and injectable hydrogel matrix based on the Schiff base structure formed between the oxidized Bletilla striata polysaccharide (BSP) and hydroxypropyltrimethylammonium chloride chitosan. Furthermore, the introduction of CuO nanoparticles encapsulated in polydopamine imparted excellent photothermal properties to the hydrogel, which promoted the release of berberine (BER) loaded on the nanoparticles and boosted the antibacterial performance. In addition to providing a reliable physical protection to the wound, the developed hydrogel, which integrated the herbal components of BSP and BER, effectively accelerated wound closure via microenvironment regulation, including alleviated inflammatory reaction, stimulated reepithelialization, and reduced oxidative stress based on the promising results from cell and animal experiments. These impressive outcomes highlighted their clinical potential in safeguarding the wound against bacterial intrusion and managing diabetic ulcers.

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Photothermal Hydrogels for Promoting Infected Wound Healing

Cited by 17 publications

References 217 publications

Review of Light-Activated Antimicrobial Nanoparticle–Polymer Composites for Biomedical Devices

Review of Light-Activated Antimicrobial Nanoparticle–Polymer Composites for Biomedical Devices

Thermo‐Responsive Hydrogels Coupled with Photothermal Agents for Biomedical Applications

Bletilla striata Polysaccharide-/Chitosan-Based Self-Healing Hydrogel with Enhanced Photothermal Effect for Rapid Healing of Diabetic Infected Wounds via the Regulation of Microenvironment

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