Photothermal Control of Membrane Permeability of Microcapsules for On-Demand Release

Jeong, Woong-Chan; Kim, Shin‐Hyun; Yang, Seung‐Man

doi:10.1021/am4037993

Cited by 44 publications

(48 citation statements)

References 22 publications

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“…Due to the heat tolerance of tumor cells being lower than normal tissue, the temperature in the region 42–47 °C can ablate tumor cells . So the tumor cells are selectively destroyed by loosening cell membranes and denaturing proteins with the localized hyperthermia . Meanwhile, the heat activates gel phase to liquid crystalline phase transition for bio‐membrane, which leads the encapsulated drugs release to kill the tumor cells .…”

Section: Introductionmentioning

confidence: 99%

Combined Near Infrared Photothermal Therapy and Chemotherapy Using Gold Nanoshells Coated Liposomes to Enhance Antitumor Effect

Luo

Bian

Liu

et al. 2016

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134

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Novel antitumor system based on the targeting photothermal and pH-responsive nanocarriers, gold nanoshells coated oleanolic acid liposomes mediating by chitosan (GNOLs), is designed and synthesized for the first time. The GNOLs present spherical and uniform size (172.03 nm) with zeta potential (20.7 ± 0.4 mV), which are more easily accumulated in tumor. Meanwhile, the GNOLs exhibit a slow and controlled release of oleanolic acid at pH 7.4, as well as a rapid release at pH 5.5, which is beneficial for tumor-targeting drug release. Under near infrared (NIR) irradiation, hyperthermia can be generated by activated gold nanoshells to perform photothermal therapy effect, which triggers drug release from the carriers by activating the gel to liquid crystalline phase transition of the liposomes. Moreover, the NIR assisting drug release can be easily and selectively activated locally due to the spatially and real-timely controllable property of light. The experimental results also verify that the GNOLs with NIR irradiation achieve more ideal antitumor effects than other oleanolic acid formulations in vitro and in vivo. Hence, the drug delivery system exhibits a great potential in chemo-photothermal antitumor therapy.

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Section: Introductionmentioning

confidence: 99%

Combined Near Infrared Photothermal Therapy and Chemotherapy Using Gold Nanoshells Coated Liposomes to Enhance Antitumor Effect

Luo

Bian

Liu

et al. 2016

Small

134

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“…Unlike most controlled delivery systems in which stimuli are applied to trigger the release or "on" state, 21,22,42,43 our design signicantly slowed down the release. Unlike most controlled delivery systems in which stimuli are applied to trigger the release or "on" state, 21,22,42,43 our design signicantly slowed down the release.…”

Section: Introductionmentioning

confidence: 99%

A photo-tunable membrane based on inter-particle crosslinking for decreasing diffusion rates

Moosa

Chen

et al. 2015

J. Mater. Chem. B

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Functional polymeric membranes are widely used to adjust and control the diffusion of molecules. Herein, photosensitive poly(hydroxycinnamic acid) (PHCA) microspheres, which were fabricated by an emulsification solvent-evaporation method, were embedded into an ethyl cellulose matrix to fabricate composite membranes with a photo-tunable property. The photoreaction of PHCA is based on the [2 + 2] cycloaddition of cinnamic moieties upon irradiation with 365 nm light. Intra-particle crosslinking in PHCA microspheres was confirmed in the solution phase, while inter-particle crosslinking between adjacent PHCA microspheres dominated the solid membrane phase. The inter-particle crosslinking turned down the permeability of the composite membranes by 74%. To prove the applicability of the designed system, the composite membrane was coated on a model drug reservoir tablet. Upon irradiating the tablet with UV light, the original permeability decreased by 57%, and consequently the diffusion rate of the cargo (Rhodamine B) from the tablet slowed down. Most importantly, the tablet showed sustained release for over 10 days. This controllability can be further tuned by adjusting the membrane thickness. Composite membranes showed excellent processing reproducibility together with consistent mechanical properties. These results demonstrate that the incorporation of photosensitive PHCA microspheres in polymeric membranes provides a promising photo-tunable material for different applications including coating and separation.

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“…Jeong et al reported the use of a microfluidic device for producing microcapsules with reversible membrane permeability that can be remotely controlled by application of near‐infrared light …”

Section: Applications Of Membranes In Microfluidicsmentioning

confidence: 99%

Review of membranes in microfluidics

Chen

Shen

2016

J of Chemical Tech & Biotech

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This review reports the progress on the recent development of membranes in microfluidics. First of all, the definition and basic concepts of membranes are given. Second, the manufacturing methods of membranes in microfluidics are illustrated and discussed. And lastly, the applications of membranes in microfluidics that are the focus of this work are discussed including cells, proteins, microreactors, gas detection, drug screening, electrokinetical fluids, pump and valve and fluid transport control, chemical reagents detection and so on. A variety of microfluidic devices designed containing membranes are expounded and analyzed. This paper will provide a valuable reference to designers who research membranes and microfluidics for various applications. © 2016 Society of Chemical Industry

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Photothermal Control of Membrane Permeability of Microcapsules for On-Demand Release

Cited by 44 publications

References 22 publications

Combined Near Infrared Photothermal Therapy and Chemotherapy Using Gold Nanoshells Coated Liposomes to Enhance Antitumor Effect

Combined Near Infrared Photothermal Therapy and Chemotherapy Using Gold Nanoshells Coated Liposomes to Enhance Antitumor Effect

A photo-tunable membrane based on inter-particle crosslinking for decreasing diffusion rates

Review of membranes in microfluidics

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