Phototherapy with artificial light suppresses dextran sulfate sodium‐induced colitis in a mouse model

Ito, Masafumi; Goto, Shigeru; Oyama, Yoshimasa; Nakano, Toshiaki; Chen, Chao‐Long; Shiraishi, Norio; Noguchi, Takayuki; Kitano, Seigo

doi:10.1111/jgh.12460

Cited by 14 publications

(16 citation statements)

References 40 publications

(75 reference statements)

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“…35 The experimental design for both studies was similar in that the light therapy was delivered before induction of colitis. 37, 38 Both studies showed a positive effect of the light treatments on experimental IBD symptoms in this model. 37, 38 The dose of light was sufficient in one study to raise serum 25(OH)D levels but in the other was not.…”

Section: Vitamin D Uvr and Experimental Ibdmentioning

confidence: 57%

“…37, 38 Both studies showed a positive effect of the light treatments on experimental IBD symptoms in this model. 37, 38 The dose of light was sufficient in one study to raise serum 25(OH)D levels but in the other was not. 37, 38 The doses of light delivered were 600mJ/cm 2 (no raise in serum 25(OH)D) on shaved mice versus 14 J/cm 2 on unshaved mice (raised serum 25(OH)D).…”

Section: Vitamin D Uvr and Experimental Ibdmentioning

confidence: 57%

“…37, 38 The dose of light was sufficient in one study to raise serum 25(OH)D levels but in the other was not. 37, 38 The doses of light delivered were 600mJ/cm 2 (no raise in serum 25(OH)D) on shaved mice versus 14 J/cm 2 on unshaved mice (raised serum 25(OH)D). 37, 38 The low dose (600mJ/cm 2 ) was associated with an increase in T reg cells.…”

Section: Vitamin D Uvr and Experimental Ibdmentioning

confidence: 96%

“…37, 38 The doses of light delivered were 600mJ/cm 2 (no raise in serum 25(OH)D) on shaved mice versus 14 J/cm 2 on unshaved mice (raised serum 25(OH)D). 37, 38 The low dose (600mJ/cm 2 ) was associated with an increase in T reg cells. 38 However T reg cells have not been shown to be important in this model of chemically induced colitis.…”

Section: Vitamin D Uvr and Experimental Ibdmentioning

confidence: 99%

“…The data suggest that there may be a vitamin D independent effect of UVR on experimental colitis. 37, 38 Future work should focus on the effects of UVR in other experimental models of IBD that involve T cells and the utilization of VDR KO mice to determine the UVR induced versus the vitamin D mediated effects of UVR treatments.…”

Section: Vitamin D Uvr and Experimental Ibdmentioning

confidence: 99%

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The role of UVR and vitamin D on T cells and inflammatory bowel disease

Bora

Cantorna

2017

Photochem Photobiol Sci

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Vitamin D deficiency is associated with the development of inflammatory bowel disease (IBD). In experimental IBD the targets of vitamin D that result in protection from IBD include gut epithelial cells, innate immune cells, T cells and the microbiota. Ultraviolet radiation (UVR) induces production of vitamin D in the skin and suppresses T cell responses in the host. There is limited data demonstrating an effect of UVR on experimental IBD but the mechanisms of UVR suppression in IBD have not been defined. There are several shared effects of vitamin D and UVR on T cells including inhibition of proliferation and suppression of IFN-γ and IL-17 producing T cells. Conversely UVR decreases and vitamin D increases IL-4 production from T cells. Together the data suggest that UVR suppression of T cells and potentially IBD are both vitamin D dependent and independent.

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Section: Vitamin D Uvr and Experimental Ibdmentioning

confidence: 57%

Section: Vitamin D Uvr and Experimental Ibdmentioning

confidence: 57%

Section: Vitamin D Uvr and Experimental Ibdmentioning

confidence: 96%

Section: Vitamin D Uvr and Experimental Ibdmentioning

confidence: 99%

Section: Vitamin D Uvr and Experimental Ibdmentioning

confidence: 99%

See 3 more Smart Citations

The role of UVR and vitamin D on T cells and inflammatory bowel disease

Bora

Cantorna

2017

Photochem Photobiol Sci

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The dark art of light measurement: accurate radiometry for low-level light therapy

et al. 2016

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Lasers and light-emitting diodes are used for a range of biomedical applications with many studies reporting their beneficial effects. However, three main concerns exist regarding much of the low-level light therapy (LLLT) or photobiomodulation literature; (1) incomplete, inaccurate and unverified irradiation parameters, (2) miscalculation of ‘dose,’ and (3) the misuse of appropriate light property terminology. The aim of this systematic review was to assess where, and to what extent, these inadequacies exist and to provide an overview of ‘best practice’ in light measurement methods and importance of correct light measurement. A review of recent relevant literature was performed in PubMed using the terms LLLT and photobiomodulation (March 2014–March 2015) to investigate the contemporary information available in LLLT and photobiomodulation literature in terms of reporting light properties and irradiation parameters. A total of 74 articles formed the basis of this systematic review. Although most articles reported beneficial effects following LLLT, the majority contained no information in terms of how light was measured (73 %) and relied on manufacturer-stated values. For all papers reviewed, missing information for specific light parameters included wavelength (3 %), light source type (8 %), power (41 %), pulse frequency (52 %), beam area (40 %), irradiance (43 %), exposure time (16 %), radiant energy (74 %) and fluence (16 %). Frequent use of incorrect terminology was also observed within the reviewed literature. A poor understanding of photophysics is evident as a significant number of papers neglected to report or misreported important radiometric data. These errors affect repeatability and reliability of studies shared between scientists, manufacturers and clinicians and could degrade efficacy of patient treatments. Researchers need a physicist or appropriately skilled engineer on the team, and manuscript reviewers should reject papers that do not report beam measurement methods and all ten key parameters: wavelength, power, irradiation time, beam area (at the skin or culture surface; this is not necessarily the same size as the aperture), radiant energy, radiant exposure, pulse parameters, number of treatments, interval between treatments and anatomical location. Inclusion of these parameters will improve the information available to compare and contrast study outcomes and improve repeatability, reliability of studies.

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Intraperitoneal Phototherapy Suppresses Inflammatory Reactions in a Surgical Model of Peritonitis

Hara

Etoh

Itai

et al. 2020

Journal of Surgical Research

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Phototherapy with artificial light suppresses dextran sulfate sodium‐induced colitis in a mouse model

Abstract: Artificial light phototherapy suppressed DSS-induced colitis in mice by suppression of pro-inflammatory cytokines and promotion of anti-inflammatory cytokines.

Cited by 14 publications

References 40 publications

The role of UVR and vitamin D on T cells and inflammatory bowel disease

The role of UVR and vitamin D on T cells and inflammatory bowel disease

The dark art of light measurement: accurate radiometry for low-level light therapy

Intraperitoneal Phototherapy Suppresses Inflammatory Reactions in a Surgical Model of Peritonitis

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