Phototherapy in dermatology: A call for action

Lim, Henry W.; Silpa‐archa, Narumol; Amadi, Ugochukwu; Menter, Alan; Voorhees, Abby S. Van; Lebwohl, Mark

doi:10.1016/j.jaad.2015.03.017

Cited by 61 publications

(66 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These mechanistic findings have suggested a physiologic role for low, non-carcinogenic doses of UV light: induction of innate immunity to protect against microbial attacks, and suppression of adaptive immunity to inhibit autoimmune or allergic responses. The latter mechanism forms the basis of UV phototherapy, which is used to treat a wide range of dermatoses in the clinic 44 .…”

Section: Light-activated Therapiesmentioning

confidence: 99%

See 1 more Smart Citation

Light in diagnosis, therapy and surgery

2017

View full text Add to dashboard Cite

Light and optical techniques have made profound impacts on modern medicine, with numerous lasers and optical devices being currently used in clinical practice to assess health and treat disease. Recent advances in biomedical optics have enabled increasingly sophisticated technologies — in particular those that integrate photonics with nanotechnology, biomaterials and genetic engineering. In this Review, we revisit the fundamentals of light–matter interactions, describe the applications of light in imaging, diagnosis, therapy and surgery, overview their clinical use, and discuss the promise of emerging light-based technologies.

show abstract

Section: Light-activated Therapiesmentioning

confidence: 99%

“…For over 90 years, UVB radiation has been used to treat psoriasis 44,45 — a chronic, immune-mediated inflammatory skin disorder affecting tens of millions of people worldwide. It is also used to treat vitiligo, atopic dermatitis and other inflammatory dermatoses.…”

Section: Light-activated Therapiesmentioning

confidence: 99%

Light in diagnosis, therapy and surgery

2017

View full text Add to dashboard Cite

show abstract

“…Professionals have already successfully exploited the benefits of photothermal, photomechanical and photochemical light‐based treatment . Some examples include photothermal effects for skin rejuvenation and for removal of hair and vascular lesions ; photomechanical skin rejuvenation using laser‐induced optical breakdown ; PUVA‐, UVB‐ and blue‐light‐based photochemical treatment of psoriasis .…”

Section: Introductionmentioning

confidence: 99%

Photobiomodulation devices for hair regrowth and wound healing: a therapy full of promise but a literature full of confusion

Mignon

Botchkareva

Uzunbajakava

et al. 2016

Experimental Dermatology

View full text Add to dashboard Cite

Photobiomodulation is reported to positively influence hair regrowth, wound healing, skin rejuvenation and psoriasis. Despite rapid translation of this science to commercial therapeutic solutions, significant gaps in our understanding of the underlying processes remain. The aim of this review was to seek greater clarity and rationality specifically for the selection of optical parameters for studies on hair regrowth and wound healing. Our investigation of 90 reports published between 1985 and 2015 revealed major inconsistencies in optical parameters selected for clinical applications. Moreover, poorly understood photoreceptors expressed in skin such as cytochrome c oxidase, cryptochromes, opsins etc. may trigger different molecular mechanisms. All this could explain the plethora of reported physiological effects of light. To derive parameters for optimal clinical efficacy of photobiomodulation, we recommend a more rational approach to underpin clinical studies, with research on molecular targets and pathways using well-defined biological model systems to enable translation of optical parameters from in vitro to in vivo. Furthermore, special attention needs to be paid when conducting studies for hair regrowth, aiming for double-blind, placebocontrolled randomized clinical trials as the gold standard for quantifying hair growth.

show abstract

“…In a recent commentary in the Journal of the American Academy of Dermatology, Henry Lim et al . called for action on phototherapy in dermatology, asking for a renewed emphasis on phototherapy training, for efforts to ensure continued availability of phototherapy, and for an increased funding of phototherapy research and development. The shortcomings in phototherapy training revealed by Danesh et al .…”

Section: Do Us Dermatology Residents Get Enough Training In Photothermentioning

confidence: 99%

Editor's Picks

2015

Photoderm Photoimm Photomed

View full text Add to dashboard Cite

Phototherapy in dermatology: A call for action

Cited by 61 publications

References 13 publications

Light in diagnosis, therapy and surgery

Light in diagnosis, therapy and surgery

Photobiomodulation devices for hair regrowth and wound healing: a therapy full of promise but a literature full of confusion

Editor's Picks

Contact Info

Product

Resources

About