2017
DOI: 10.1038/s41551-016-0008
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Light in diagnosis, therapy and surgery

Abstract: Light and optical techniques have made profound impacts on modern medicine, with numerous lasers and optical devices being currently used in clinical practice to assess health and treat disease. Recent advances in biomedical optics have enabled increasingly sophisticated technologies — in particular those that integrate photonics with nanotechnology, biomaterials and genetic engineering. In this Review, we revisit the fundamentals of light–matter interactions, describe the applications of light in imaging, dia… Show more

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Cited by 583 publications
(479 citation statements)
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“…One of the critical problems in a new precise light‐induced medical technology is delivering of the photonic flux to the targeted body location . Basic physical processes of optical absorption and scattering under UV, visible, and IR light illumination of a human skin and tissues are limited by the depth of the light diffusion and penetration inside a human body .…”
Section: Biomedical Integrated Optics and Related Materialsmentioning
confidence: 99%
“…One of the critical problems in a new precise light‐induced medical technology is delivering of the photonic flux to the targeted body location . Basic physical processes of optical absorption and scattering under UV, visible, and IR light illumination of a human skin and tissues are limited by the depth of the light diffusion and penetration inside a human body .…”
Section: Biomedical Integrated Optics and Related Materialsmentioning
confidence: 99%
“…In this work synthetic dyes were employed as gain material, but other biocompatible materials could be used, for example fluorescent proteins [36,37], vitamins [15] and medically approved dyes (fluorescein and indocyanine green). Availability of biocompatible and biodegradable microlasers made from materials approved for medical use or substance already present in the human body may open new opportunities for light-based diagnostics and therapies [38] as well as basic research.…”
Section: Discussionmentioning
confidence: 99%
“…However,r igid metal electrodes often lead to acute foreign body reactions and cause damage to surrounding tissues during use,including neuronal death and glial scarring around the probe. [89] By using ahybrid optical fiber, we may simultaneously record signals and selectively turn specific neurons on or off via light. Improved neuron attachment and viability were observed during an electrophysiology experiment.…”
Section: Sensingmentioning
confidence: 99%