Phototherapy for Itch

Zhong, Connie S.; Elmariah, Sarina B.

doi:10.1016/j.det.2019.08.008

Cited by 14 publications

(12 citation statements)

References 111 publications

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“…PUVA phototherapy is applied to treat inflammatory skin diseases, including psoriasis, vitiligo, atopic dermatitis, contact dermatitis, cutaneous T-cell lymphoma, chronic pruritus, mastocytosis, or polymorphous light eruption. Psoralens are phototoxic compounds that, after absorbing photons of light, induce photochemical reactions that alter cellular homeostasis [ 20 , 21 , 22 , 23 , 24 ]. The cytotoxic effect on malignant melanoma cells has already been demonstrated in the case of phototherapy using psoralens (8-MOP, 5-MOP) and UVAR [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Ketoprofen Combined with UVA Irradiation Exerts Higher Selectivity in the Mode of Action against Melanotic Melanoma Cells than against Normal Human Melanocytes

Banach

Kowalska

Rzepka

et al. 2021

IJMS

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Malignant melanoma is responsible for the majority of skin cancer-related deaths. The methods of cancer treatment include surgical removal, chemotherapy, immunotherapy, and targeted therapy. However, neither of these methods gives satisfactory results. Therefore, the development of new anticancer therapeutic strategies is very important and may extend the life span of people suffering from melanoma. The aim of this study was to examine the effect of ketoprofen (KTP) and UVA radiation (UVAR) therapy on cell proliferation, apoptosis, and cell cycle distribution in both melanotic melanoma cells (COLO829) and human melanocytes (HEMn-DP) in relation to its supportive effect in the treatment of melanoma. The therapy combining the use of pre-incubation with KTP and UVAR causes a significant increase in the anti-proliferative properties of ketoprofen towards melanoma cells and the co-exposure of melanotic melanoma cells induced apoptosis shown as the mitochondrial membrane breakdown, cell-cycle deregulation, and DNA fragmentation. Moreover, co-treatment led to GSH depletion showing its pro-apoptotic effect dependent on ROS overproduction. The treatment did not show a significant effect on normal cells—melanocytes—which indicates its high selectivity. The results suggest a possible benefit from the use of the ketoprofen and ultraviolet A irradiation as a new concept of melanotic melanoma therapy.

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Section: Discussionmentioning

confidence: 99%

Ketoprofen Combined with UVA Irradiation Exerts Higher Selectivity in the Mode of Action against Melanotic Melanoma Cells than against Normal Human Melanocytes

Banach

Kowalska

Rzepka

et al. 2021

IJMS

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“…43 Pada pruritus kronis, narrowband ultraviolet B (NB-UVB) lebih dipilih karena efektivitas yang baik, tersedia secara luas, memiliki efek eritemogenik yang lebih rendah, serta durasi yang lebih singkat. 11,51 Radiasi UVA (320 nm hingga 400 nm) atau UVB (290 nm hingga 320 nm) dapat menginduksi apoptosis sel keratinosit, sel T efektor, sel mast, dan sel Langerhans. 11,51 Apoptosis terjadi akibat peningkatan reactive oxygen species, kerusakan DNA, dan peningkatan regulasi fas ligan.…”

Section: Fototerapi (Loe 1-2)unclassified

“…11,51 Radiasi UVA (320 nm hingga 400 nm) atau UVB (290 nm hingga 320 nm) dapat menginduksi apoptosis sel keratinosit, sel T efektor, sel mast, dan sel Langerhans. 11,51 Apoptosis terjadi akibat peningkatan reactive oxygen species, kerusakan DNA, dan peningkatan regulasi fas ligan. 51 Selain itu, terjadi penurunan degranulasi sel mast dan sitokin pro-inflamasi, serta terjadi modulasi sistem saraf.…”

Section: Fototerapi (Loe 1-2)unclassified

Perkembangan Terapi Sistemik pada Pruritus

Andardewi¹,

Budianti²,

Legiawati³

et al. 2022

J. Kdokt Meditek

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Pruritus merupakan sensasi tidak nyaman yang mencetuskan keinginan untuk menggaruk. Sensasi tersebut disebabkan oleh berbagai hal, misalnya penyakit kulit, penyakit sistemik, atau idiopatik, gangguan psikiatri, serta penyakit neurologis. Pruritus menjadi masalah kesehatan karena dapat memberi dampak negatif terhadap kualitas hidup pasien. Pendekatan tata laksana pruritus diberikan secara bertingkat mulai dari terapi dasar, terapi target, dan terapi simtomatik. Pada kasus pruritus kronik yang refrakter maupun pruritus tanpa sebab yang diketahui, terapi simtomatik berperan besar dan dapat diberikan pada pasien tersebut. Tata laksana pada pruritus kronik saat ini banyak diteliti seiring dengan ditemukan berbagai mekanisme yang mendasari terjadinya pruritus. Sesuai dengan patofisiologi dari pruritus, terapi sistemik yang dikembangkan menargetkan pada reseptor spesifik di sistem saraf dan sistem imunitas yang berperan pada jalur sinyal pruritus. Berbagai terapi terbaru yang masih diteliti dalam uji klinis menunjukkan hasil yang menjanjikan dan berpotensi menjadi pilihan terapi pada pasien dengan pruritus kronik.

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“…One way NB-UVB reduces the symptoms of pruritus is by decreasing the inflammatory cytokine, IL-31, involved in the itch pathway. Recent reviews support the use of NB-UVB in reducing pruritus for patients with uremic pruritus secondary to chronic kidney disease, cholestasis-induced pruritus, prurigo nodularis, HIV-induced pruritus, and other inflammatory dermatoses that cause chronic pruritus [ 45 ].…”

Section: Reviewmentioning

confidence: 99%

An Update on Narrowband Ultraviolet B Therapy for the Treatment of Skin Diseases

Myers¹,

Kheradmand²,

Miller³

2021

Cureus

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The objective of this review is to provide an update on narrowband ultraviolet B (NB-UVB) as a treatment for various skin conditions. NB-UVB works by suppressing the cutaneous cell-mediated immune response and has been shown to be an efficacious and clinically tolerable treatment for a range of inflammatory dermatoses. A literature search was conducted by advanced searches of PubMed for NB-UVB treatment of dermatologic skin diseases with a focus on reports from 2010 to 2021, including both office-based and home-based phototherapy (HBPT). Data were prioritized based on studies with a high level of evidence using the Oxford Evidence-Based Medicine guidance. We found that NB-UVB continues to serve as an effective form of therapy for several cutaneous conditions, including vitiligo, psoriasis, atopic dermatitis, mycosis fungoides, and other inflammatory dermatoses. The recent introduction of Janus kinase inhibitors in combination with NB-UVB suggests future promise in the treatment of vitiligo. Despite its rise in popularity, a decline was seen in office-based NB-UVB treatment during the coronavirus disease 2019 pandemic. Options are available to deliver NB-UVB at home with comparable efficacy to office-based treatments. In conclusion, for a select group of patients and conditions, NB-UVB continues to serve as an effective treatment modality with minimal side effects, with HBPT serving as an option to improve patient compliance.

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Phototherapy for Itch

Cited by 14 publications

References 111 publications

Ketoprofen Combined with UVA Irradiation Exerts Higher Selectivity in the Mode of Action against Melanotic Melanoma Cells than against Normal Human Melanocytes

Ketoprofen Combined with UVA Irradiation Exerts Higher Selectivity in the Mode of Action against Melanotic Melanoma Cells than against Normal Human Melanocytes

Perkembangan Terapi Sistemik pada Pruritus

An Update on Narrowband Ultraviolet B Therapy for the Treatment of Skin Diseases

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